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Factors That Predict Remission of Infant Atopic Dermatitis: A Systematic Review.

von Kobyletzki, Laura LU ; Svensson, Åke LU ; Apfelbacher, Christian and Schmitt, Jochen (2015) In Acta Dermato-Venereologica 95(4). p.389-394
Abstract
The individual prognosis of infants with atopic dermatitis (AD) is important for parents, healthcare professionals, and society. The aim of this study was to investigate predictors for remission of infant AD until school age. A systematic review was carried out of clinical and epidemiological studies investigating the effect of filaggrin gene (FLG) loss-of-function mutations, sex, exposure to pets, topical anti-inflammatory treatment, disease severity, and atopic sensitization during infancy on complete remission of infant-onset AD until 6-7 years of age. Systematic electronic searches until September 2013, data abstraction, and study quality assessment (Newcastle-Ottawa Scale) were performed. From 3316 abstracts identified, 2 studies of... (More)
The individual prognosis of infants with atopic dermatitis (AD) is important for parents, healthcare professionals, and society. The aim of this study was to investigate predictors for remission of infant AD until school age. A systematic review was carried out of clinical and epidemiological studies investigating the effect of filaggrin gene (FLG) loss-of-function mutations, sex, exposure to pets, topical anti-inflammatory treatment, disease severity, and atopic sensitization during infancy on complete remission of infant-onset AD until 6-7 years of age. Systematic electronic searches until September 2013, data abstraction, and study quality assessment (Newcastle-Ottawa Scale) were performed. From 3316 abstracts identified, 2 studies of good study quality were included. Parental allergies and sex did not significantly affect remission. For non-remission of AD, the included articles reported an association with any atopic sensitization at 2 years old (adjusted odds ratio [aOR] 2.76; 95% confidence interval (CI) 1.29-5.91), frequent scratching with early AD (aOR 5.86; 95% CI 3.04-11.29), severity score at 2 years old (aOR 1.10; 95% CI 1.07-1.14), and exposure to pets (cat OR 2.33; 95% CI 0.85-6.38). It is largely unknown which factors predict remission of infant AD. This is a highly relevant research gap that hinders patient information on the prognosis of infant-onset AD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Dermato-Venereologica
volume
95
issue
4
pages
389 - 394
publisher
Medical Journals Limited
external identifiers
  • pmid:25117201
  • wos:000352751200002
  • scopus:84924985136
ISSN
1651-2057
DOI
10.2340/00015555-1941
language
English
LU publication?
yes
id
0fcd82f9-0bca-4f57-be88-cd0ef11366a7 (old id 4614820)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25117201?dopt=Abstract
date added to LUP
2014-09-06 23:11:00
date last changed
2017-01-01 03:27:51
@article{0fcd82f9-0bca-4f57-be88-cd0ef11366a7,
  abstract     = {The individual prognosis of infants with atopic dermatitis (AD) is important for parents, healthcare professionals, and society. The aim of this study was to investigate predictors for remission of infant AD until school age. A systematic review was carried out of clinical and epidemiological studies investigating the effect of filaggrin gene (FLG) loss-of-function mutations, sex, exposure to pets, topical anti-inflammatory treatment, disease severity, and atopic sensitization during infancy on complete remission of infant-onset AD until 6-7 years of age. Systematic electronic searches until September 2013, data abstraction, and study quality assessment (Newcastle-Ottawa Scale) were performed. From 3316 abstracts identified, 2 studies of good study quality were included. Parental allergies and sex did not significantly affect remission. For non-remission of AD, the included articles reported an association with any atopic sensitization at 2 years old (adjusted odds ratio [aOR] 2.76; 95% confidence interval (CI) 1.29-5.91), frequent scratching with early AD (aOR 5.86; 95% CI 3.04-11.29), severity score at 2 years old (aOR 1.10; 95% CI 1.07-1.14), and exposure to pets (cat OR 2.33; 95% CI 0.85-6.38). It is largely unknown which factors predict remission of infant AD. This is a highly relevant research gap that hinders patient information on the prognosis of infant-onset AD.},
  author       = {von Kobyletzki, Laura and Svensson, Åke and Apfelbacher, Christian and Schmitt, Jochen},
  issn         = {1651-2057},
  language     = {eng},
  number       = {4},
  pages        = {389--394},
  publisher    = {Medical Journals Limited},
  series       = {Acta Dermato-Venereologica},
  title        = {Factors That Predict Remission of Infant Atopic Dermatitis: A Systematic Review.},
  url          = {http://dx.doi.org/10.2340/00015555-1941},
  volume       = {95},
  year         = {2015},
}