KIR B haplotype donors confer a reduced risk of relapse after haploidentical transplantation in children with acute lymphoblastic leukemia.
(2014) In Blood 124(17). p.2744-2747- Abstract
- We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk of relapse and probability of event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL) who received HLA-haploidentical transplantation of ex vivo T-cell depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors and the KIR B-content score was determined in the 63 KIR haplotype-B donors. Patients transplanted from a KIR haplotype-B donor had a significantly better EFS than those transplanted from a KIR A-donor (50.6% versus 29.5%, respectively, p=0.033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk of relapse (Log-rank test for trend... (More)
- We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk of relapse and probability of event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL) who received HLA-haploidentical transplantation of ex vivo T-cell depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors and the KIR B-content score was determined in the 63 KIR haplotype-B donors. Patients transplanted from a KIR haplotype-B donor had a significantly better EFS than those transplanted from a KIR A-donor (50.6% versus 29.5%, respectively, p=0.033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk of relapse (Log-rank test for trend p=0.026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with ALL with the aim of choosing, whenever possible, a KIR haplotype-B donor with a high KIR B-content score. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4614871
- author
- Oevermann, Lena ; Michaelis, Sebastian U ; Mezger, Markus ; Lang, Peter ; Toporski, Jacek LU ; Bertaina, Alice ; Zecca, Marco ; Moretta, Lorenzo ; Locatelli, Franco and Handgretinger, Rupert
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 124
- issue
- 17
- pages
- 2744 - 2747
- publisher
- American Society of Hematology
- external identifiers
-
- pmid:25115891
- wos:000347457500021
- scopus:84908243745
- pmid:25115891
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2014-03-565069
- language
- English
- LU publication?
- yes
- id
- c4356305-bdde-4c86-abf6-1a5c8b57b260 (old id 4614871)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25115891?dopt=Abstract
- date added to LUP
- 2016-04-01 10:05:24
- date last changed
- 2022-04-27 18:25:20
@article{c4356305-bdde-4c86-abf6-1a5c8b57b260, abstract = {{We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk of relapse and probability of event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL) who received HLA-haploidentical transplantation of ex vivo T-cell depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors and the KIR B-content score was determined in the 63 KIR haplotype-B donors. Patients transplanted from a KIR haplotype-B donor had a significantly better EFS than those transplanted from a KIR A-donor (50.6% versus 29.5%, respectively, p=0.033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk of relapse (Log-rank test for trend p=0.026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with ALL with the aim of choosing, whenever possible, a KIR haplotype-B donor with a high KIR B-content score.}}, author = {{Oevermann, Lena and Michaelis, Sebastian U and Mezger, Markus and Lang, Peter and Toporski, Jacek and Bertaina, Alice and Zecca, Marco and Moretta, Lorenzo and Locatelli, Franco and Handgretinger, Rupert}}, issn = {{1528-0020}}, language = {{eng}}, number = {{17}}, pages = {{2744--2747}}, publisher = {{American Society of Hematology}}, series = {{Blood}}, title = {{KIR B haplotype donors confer a reduced risk of relapse after haploidentical transplantation in children with acute lymphoblastic leukemia.}}, url = {{http://dx.doi.org/10.1182/blood-2014-03-565069}}, doi = {{10.1182/blood-2014-03-565069}}, volume = {{124}}, year = {{2014}}, }