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KIR B haplotype donors confer a reduced risk of relapse after haploidentical transplantation in children with acute lymphoblastic leukemia.

Oevermann, Lena; Michaelis, Sebastian U; Mezger, Markus; Lang, Peter; Toporski, Jacek LU ; Bertaina, Alice; Zecca, Marco; Moretta, Lorenzo; Locatelli, Franco and Handgretinger, Rupert (2014) In Blood 124(17). p.2744-2747
Abstract
We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk of relapse and probability of event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL) who received HLA-haploidentical transplantation of ex vivo T-cell depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors and the KIR B-content score was determined in the 63 KIR haplotype-B donors. Patients transplanted from a KIR haplotype-B donor had a significantly better EFS than those transplanted from a KIR A-donor (50.6% versus 29.5%, respectively, p=0.033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk of relapse (Log-rank test for trend... (More)
We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk of relapse and probability of event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL) who received HLA-haploidentical transplantation of ex vivo T-cell depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors and the KIR B-content score was determined in the 63 KIR haplotype-B donors. Patients transplanted from a KIR haplotype-B donor had a significantly better EFS than those transplanted from a KIR A-donor (50.6% versus 29.5%, respectively, p=0.033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk of relapse (Log-rank test for trend p=0.026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with ALL with the aim of choosing, whenever possible, a KIR haplotype-B donor with a high KIR B-content score. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
124
issue
17
pages
2744 - 2747
publisher
American Society of Hematology
external identifiers
  • pmid:25115891
  • wos:000347457500021
  • scopus:84908243745
ISSN
1528-0020
DOI
10.1182/blood-2014-03-565069
language
English
LU publication?
yes
id
c4356305-bdde-4c86-abf6-1a5c8b57b260 (old id 4614871)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25115891?dopt=Abstract
date added to LUP
2014-09-06 22:46:09
date last changed
2017-10-22 03:06:55
@article{c4356305-bdde-4c86-abf6-1a5c8b57b260,
  abstract     = {We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk of relapse and probability of event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL) who received HLA-haploidentical transplantation of ex vivo T-cell depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors and the KIR B-content score was determined in the 63 KIR haplotype-B donors. Patients transplanted from a KIR haplotype-B donor had a significantly better EFS than those transplanted from a KIR A-donor (50.6% versus 29.5%, respectively, p=0.033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk of relapse (Log-rank test for trend p=0.026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with ALL with the aim of choosing, whenever possible, a KIR haplotype-B donor with a high KIR B-content score.},
  author       = {Oevermann, Lena and Michaelis, Sebastian U and Mezger, Markus and Lang, Peter and Toporski, Jacek and Bertaina, Alice and Zecca, Marco and Moretta, Lorenzo and Locatelli, Franco and Handgretinger, Rupert},
  issn         = {1528-0020},
  language     = {eng},
  number       = {17},
  pages        = {2744--2747},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {KIR B haplotype donors confer a reduced risk of relapse after haploidentical transplantation in children with acute lymphoblastic leukemia.},
  url          = {http://dx.doi.org/10.1182/blood-2014-03-565069},
  volume       = {124},
  year         = {2014},
}