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KIR B haplotype donors confer a reduced risk of relapse after haploidentical transplantation in children with acute lymphoblastic leukemia.

Oevermann, Lena ; Michaelis, Sebastian U ; Mezger, Markus ; Lang, Peter ; Toporski, Jacek LU ; Bertaina, Alice ; Zecca, Marco ; Moretta, Lorenzo ; Locatelli, Franco and Handgretinger, Rupert (2014) In Blood 124(17). p.2744-2747
Abstract
We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk of relapse and probability of event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL) who received HLA-haploidentical transplantation of ex vivo T-cell depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors and the KIR B-content score was determined in the 63 KIR haplotype-B donors. Patients transplanted from a KIR haplotype-B donor had a significantly better EFS than those transplanted from a KIR A-donor (50.6% versus 29.5%, respectively, p=0.033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk of relapse (Log-rank test for trend... (More)
We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk of relapse and probability of event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL) who received HLA-haploidentical transplantation of ex vivo T-cell depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors and the KIR B-content score was determined in the 63 KIR haplotype-B donors. Patients transplanted from a KIR haplotype-B donor had a significantly better EFS than those transplanted from a KIR A-donor (50.6% versus 29.5%, respectively, p=0.033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk of relapse (Log-rank test for trend p=0.026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with ALL with the aim of choosing, whenever possible, a KIR haplotype-B donor with a high KIR B-content score. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
124
issue
17
pages
2744 - 2747
publisher
American Society of Hematology
external identifiers
  • pmid:25115891
  • wos:000347457500021
  • scopus:84908243745
  • pmid:25115891
ISSN
1528-0020
DOI
10.1182/blood-2014-03-565069
language
English
LU publication?
yes
id
c4356305-bdde-4c86-abf6-1a5c8b57b260 (old id 4614871)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25115891?dopt=Abstract
date added to LUP
2016-04-01 10:05:24
date last changed
2022-04-27 18:25:20
@article{c4356305-bdde-4c86-abf6-1a5c8b57b260,
  abstract     = {{We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk of relapse and probability of event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL) who received HLA-haploidentical transplantation of ex vivo T-cell depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors and the KIR B-content score was determined in the 63 KIR haplotype-B donors. Patients transplanted from a KIR haplotype-B donor had a significantly better EFS than those transplanted from a KIR A-donor (50.6% versus 29.5%, respectively, p=0.033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk of relapse (Log-rank test for trend p=0.026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with ALL with the aim of choosing, whenever possible, a KIR haplotype-B donor with a high KIR B-content score.}},
  author       = {{Oevermann, Lena and Michaelis, Sebastian U and Mezger, Markus and Lang, Peter and Toporski, Jacek and Bertaina, Alice and Zecca, Marco and Moretta, Lorenzo and Locatelli, Franco and Handgretinger, Rupert}},
  issn         = {{1528-0020}},
  language     = {{eng}},
  number       = {{17}},
  pages        = {{2744--2747}},
  publisher    = {{American Society of Hematology}},
  series       = {{Blood}},
  title        = {{KIR B haplotype donors confer a reduced risk of relapse after haploidentical transplantation in children with acute lymphoblastic leukemia.}},
  url          = {{http://dx.doi.org/10.1182/blood-2014-03-565069}},
  doi          = {{10.1182/blood-2014-03-565069}},
  volume       = {{124}},
  year         = {{2014}},
}