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Cardiac regeneration in vivo: Mending the heart from within?

Bergmann, Olaf LU and Jovinge, Stefan LU (2014) In Stem Cell Research 13(3). p.523-531
Abstract
A growing body of evidence has shown that the heart is not terminally differentiated but continues to renew its cardiomyocytes even after the neonatal period. This new view of the heart increases hope for changing the strategy for treating cardiac injuries toward regenerative approaches. However, the magnitude and clinical significance of this process in homeostasis and disease and the underlying cellular and molecular mechanisms have been heavily debated. Numerous candidates for so-called cardiac stem cells (CSCs) have been proposed, but the different characteristics of these candidates make it difficult to identify the inherent source of regeneration. In this review, we revisit the field of cardiac stem cells and endogenous regeneration... (More)
A growing body of evidence has shown that the heart is not terminally differentiated but continues to renew its cardiomyocytes even after the neonatal period. This new view of the heart increases hope for changing the strategy for treating cardiac injuries toward regenerative approaches. However, the magnitude and clinical significance of this process in homeostasis and disease and the underlying cellular and molecular mechanisms have been heavily debated. Numerous candidates for so-called cardiac stem cells (CSCs) have been proposed, but the different characteristics of these candidates make it difficult to identify the inherent source of regeneration. In this review, we revisit the field of cardiac stem cells and endogenous regeneration to elaborate how these fields may contribute to future regenerative strategies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Stem Cell Research
volume
13
issue
3
pages
523 - 531
publisher
Elsevier
external identifiers
  • pmid:25108891
  • wos:000347732100002
  • scopus:84911371541
ISSN
1876-7753
DOI
10.1016/j.scr.2014.07.002
language
English
LU publication?
yes
id
d96c321e-7f70-435f-933d-4e45f2050c2f (old id 4615003)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25108891?dopt=Abstract
date added to LUP
2014-09-05 23:25:02
date last changed
2017-11-19 03:11:19
@article{d96c321e-7f70-435f-933d-4e45f2050c2f,
  abstract     = {A growing body of evidence has shown that the heart is not terminally differentiated but continues to renew its cardiomyocytes even after the neonatal period. This new view of the heart increases hope for changing the strategy for treating cardiac injuries toward regenerative approaches. However, the magnitude and clinical significance of this process in homeostasis and disease and the underlying cellular and molecular mechanisms have been heavily debated. Numerous candidates for so-called cardiac stem cells (CSCs) have been proposed, but the different characteristics of these candidates make it difficult to identify the inherent source of regeneration. In this review, we revisit the field of cardiac stem cells and endogenous regeneration to elaborate how these fields may contribute to future regenerative strategies.},
  author       = {Bergmann, Olaf and Jovinge, Stefan},
  issn         = {1876-7753},
  language     = {eng},
  number       = {3},
  pages        = {523--531},
  publisher    = {Elsevier},
  series       = {Stem Cell Research},
  title        = {Cardiac regeneration in vivo: Mending the heart from within?},
  url          = {http://dx.doi.org/10.1016/j.scr.2014.07.002},
  volume       = {13},
  year         = {2014},
}