Cardiac regeneration in vivo: Mending the heart from within?
(2014) In Stem Cell Research 13(3). p.523-531- Abstract
- A growing body of evidence has shown that the heart is not terminally differentiated but continues to renew its cardiomyocytes even after the neonatal period. This new view of the heart increases hope for changing the strategy for treating cardiac injuries toward regenerative approaches. However, the magnitude and clinical significance of this process in homeostasis and disease and the underlying cellular and molecular mechanisms have been heavily debated. Numerous candidates for so-called cardiac stem cells (CSCs) have been proposed, but the different characteristics of these candidates make it difficult to identify the inherent source of regeneration. In this review, we revisit the field of cardiac stem cells and endogenous regeneration... (More)
- A growing body of evidence has shown that the heart is not terminally differentiated but continues to renew its cardiomyocytes even after the neonatal period. This new view of the heart increases hope for changing the strategy for treating cardiac injuries toward regenerative approaches. However, the magnitude and clinical significance of this process in homeostasis and disease and the underlying cellular and molecular mechanisms have been heavily debated. Numerous candidates for so-called cardiac stem cells (CSCs) have been proposed, but the different characteristics of these candidates make it difficult to identify the inherent source of regeneration. In this review, we revisit the field of cardiac stem cells and endogenous regeneration to elaborate how these fields may contribute to future regenerative strategies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4615003
- author
- Bergmann, Olaf LU and Jovinge, Stefan LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Stem Cell Research
- volume
- 13
- issue
- 3
- pages
- 523 - 531
- publisher
- Elsevier
- external identifiers
-
- pmid:25108891
- wos:000347732100002
- scopus:84911371541
- ISSN
- 1876-7753
- DOI
- 10.1016/j.scr.2014.07.002
- language
- English
- LU publication?
- yes
- id
- d96c321e-7f70-435f-933d-4e45f2050c2f (old id 4615003)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25108891?dopt=Abstract
- date added to LUP
- 2016-04-01 10:28:44
- date last changed
- 2022-08-12 20:13:30
@article{d96c321e-7f70-435f-933d-4e45f2050c2f,
abstract = {{A growing body of evidence has shown that the heart is not terminally differentiated but continues to renew its cardiomyocytes even after the neonatal period. This new view of the heart increases hope for changing the strategy for treating cardiac injuries toward regenerative approaches. However, the magnitude and clinical significance of this process in homeostasis and disease and the underlying cellular and molecular mechanisms have been heavily debated. Numerous candidates for so-called cardiac stem cells (CSCs) have been proposed, but the different characteristics of these candidates make it difficult to identify the inherent source of regeneration. In this review, we revisit the field of cardiac stem cells and endogenous regeneration to elaborate how these fields may contribute to future regenerative strategies.}},
author = {{Bergmann, Olaf and Jovinge, Stefan}},
issn = {{1876-7753}},
language = {{eng}},
number = {{3}},
pages = {{523--531}},
publisher = {{Elsevier}},
series = {{Stem Cell Research}},
title = {{Cardiac regeneration in vivo: Mending the heart from within?}},
url = {{https://lup.lub.lu.se/search/files/1874133/8310854.pdf}},
doi = {{10.1016/j.scr.2014.07.002}},
volume = {{13}},
year = {{2014}},
}