Relation between plasma homocysteine and Alzheimer's disease.
(2002) In Dementia and Geriatric Cognitive Disorders 14(1). p.41467-41467- Abstract
- OBJECTIVE: Several studies have shown that plasma total homocysteine (tHcy) concentration is elevated in Alzheimer's disease (AD). However, it is not clear whether elevated plasma tHcy is a primary cause or a consequence of AD. METHOD: To elucidate this question, we have analysed plasma homocysteine and its determinants in patients with early (EOAD)- and late-onset AD (LOAD) and compared the findings with those in vascular dementia (VaD) and age- and sex-matched control subjects. RESULTS: One of the main findings in the present study is that in EOAD there is no change in the levels of either plasma tHcy or its determinants compared with an age- and sex-matched control group. The fact that plasma tHcy concentration is normal in EOAD thus... (More)
- OBJECTIVE: Several studies have shown that plasma total homocysteine (tHcy) concentration is elevated in Alzheimer's disease (AD). However, it is not clear whether elevated plasma tHcy is a primary cause or a consequence of AD. METHOD: To elucidate this question, we have analysed plasma homocysteine and its determinants in patients with early (EOAD)- and late-onset AD (LOAD) and compared the findings with those in vascular dementia (VaD) and age- and sex-matched control subjects. RESULTS: One of the main findings in the present study is that in EOAD there is no change in the levels of either plasma tHcy or its determinants compared with an age- and sex-matched control group. The fact that plasma tHcy concentration is normal in EOAD thus indicates that elevated plasma tHcy is not the primary cause of the disease. Another main finding is that patients with mixed dementia (AD and VaD) and patients with VaD showed significantly increased plasma tHcy concentration compared with controls and that plasma tHCy concentration in patients with LOAD and a history of additional cardiovascular disease was elevated compared both with AD patients without such a history and with the controls. Thus, there is an association between elevated plasma tHcy and vascular disease. A third main finding is that patients with AD who were followed up for several years showed a clinical deterioration of dementia and an elevation of plasma tHcy concentration. This finding likewise supports the notion that elevated plasma tHcy is not the primary cause of the disease. CONCLUSIONS: The findings suggest that elevated plasma tHcy is not the primary cause of the disease. Furthermore, the findings indicate that elevated plasma tHcy might be a reflection of concomitant vascular disease in AD patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/108673
- author
- Nilsson, Karin ; Gustafson, Lars LU and Hultberg, Björn LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Homocysteine : blood, Female, Alzheimer Disease : blood, 80 and over, Aged, Support, Non-U.S. Gov't, Vascular Diseases : blood, Human, Male, Matched-Pair Analysis
- in
- Dementia and Geriatric Cognitive Disorders
- volume
- 14
- issue
- 1
- pages
- 41467 - 41467
- publisher
- Karger
- external identifiers
-
- pmid:12053126
- wos:000176409300002
- scopus:0036281494
- ISSN
- 1420-8008
- DOI
- 10.1159/000058327
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Division of Clinical Chemistry and Pharmacology (013250300)
- id
- 462ccec3-f625-4399-8cc4-f06854740fd8 (old id 108673)
- alternative location
- http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12053126&dopt=Abstract
- date added to LUP
- 2016-04-01 11:35:38
- date last changed
- 2022-03-12 21:55:34
@article{462ccec3-f625-4399-8cc4-f06854740fd8,
abstract = {{OBJECTIVE: Several studies have shown that plasma total homocysteine (tHcy) concentration is elevated in Alzheimer's disease (AD). However, it is not clear whether elevated plasma tHcy is a primary cause or a consequence of AD. METHOD: To elucidate this question, we have analysed plasma homocysteine and its determinants in patients with early (EOAD)- and late-onset AD (LOAD) and compared the findings with those in vascular dementia (VaD) and age- and sex-matched control subjects. RESULTS: One of the main findings in the present study is that in EOAD there is no change in the levels of either plasma tHcy or its determinants compared with an age- and sex-matched control group. The fact that plasma tHcy concentration is normal in EOAD thus indicates that elevated plasma tHcy is not the primary cause of the disease. Another main finding is that patients with mixed dementia (AD and VaD) and patients with VaD showed significantly increased plasma tHcy concentration compared with controls and that plasma tHCy concentration in patients with LOAD and a history of additional cardiovascular disease was elevated compared both with AD patients without such a history and with the controls. Thus, there is an association between elevated plasma tHcy and vascular disease. A third main finding is that patients with AD who were followed up for several years showed a clinical deterioration of dementia and an elevation of plasma tHcy concentration. This finding likewise supports the notion that elevated plasma tHcy is not the primary cause of the disease. CONCLUSIONS: The findings suggest that elevated plasma tHcy is not the primary cause of the disease. Furthermore, the findings indicate that elevated plasma tHcy might be a reflection of concomitant vascular disease in AD patients.}},
author = {{Nilsson, Karin and Gustafson, Lars and Hultberg, Björn}},
issn = {{1420-8008}},
keywords = {{Homocysteine : blood; Female; Alzheimer Disease : blood; 80 and over; Aged; Support; Non-U.S. Gov't; Vascular Diseases : blood; Human; Male; Matched-Pair Analysis}},
language = {{eng}},
number = {{1}},
pages = {{41467--41467}},
publisher = {{Karger}},
series = {{Dementia and Geriatric Cognitive Disorders}},
title = {{Relation between plasma homocysteine and Alzheimer's disease.}},
url = {{http://dx.doi.org/10.1159/000058327}},
doi = {{10.1159/000058327}},
volume = {{14}},
year = {{2002}},
}