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Sleep duration and insulin resistance in individuals without type 2 diabetes: The PPP-Botnia Study

Pyykkonen, Antti-Jussi; Isomaa, Bo; Pesonen, Anu-Katriina; Eriksson, Johan G.; Groop, Leif LU ; Tuomi, Tiinamaija and Raikkonen, Katri (2014) In Annals of Medicine 46(5). p.324-329
Abstract
Introduction. Both short and long sleep duration may increase risk of type 2 diabetes (diabetes). We studied if short and long sleep durations were associated with insulin resistance (IR) and insulin secretion in individuals without diabetes, and if the associations remained after we excluded individuals who reported more frequent and severe complaints of sleep apnea and insomnia. Participants and methods. An oral glucose tolerance test (OGTT) was performed for 722 adults without diabetes. Indices of IR and insulin secretion were calculated. Sleep duration and complaints of sleep apnea and insomnia were self-reported. Results. In comparison to average sleepers (6 - 9 h/night), short sleepers (< 6 h/night) had higher 120-min insulin and... (More)
Introduction. Both short and long sleep duration may increase risk of type 2 diabetes (diabetes). We studied if short and long sleep durations were associated with insulin resistance (IR) and insulin secretion in individuals without diabetes, and if the associations remained after we excluded individuals who reported more frequent and severe complaints of sleep apnea and insomnia. Participants and methods. An oral glucose tolerance test (OGTT) was performed for 722 adults without diabetes. Indices of IR and insulin secretion were calculated. Sleep duration and complaints of sleep apnea and insomnia were self-reported. Results. In comparison to average sleepers (6 - 9 h/night), short sleepers (< 6 h/night) had higher 120-min insulin and AUC glucose, and long sleepers (>= 9 h/night) had higher fasting and 120-min insulin, 120-min glucose, and HOMA(IR) and lower Insulin Sensitivity Index. After adjusting for confounders and after excluding individuals who reported more frequent and severe complaints of sleep apnea and insomnia, long sleep duration remained significantly associated with IR and insulin secretion. Discussion. Long but not short sleep duration is associated with IR and insulin secretion in individuals without diabetes whether or not accompanied by sleep complaints. Long sleepers may benefit from targeted preventions and interventions that aim at reducing risk of future diabetes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Insulin resistance, sleep complaints, sleep duration
in
Annals of Medicine
volume
46
issue
5
pages
324 - 329
publisher
Informa Healthcare
external identifiers
  • wos:000340456400012
  • scopus:84905447710
ISSN
1365-2060
DOI
10.3109/07853890.2014.902226
language
English
LU publication?
yes
id
539d9476-62b7-47aa-8b0d-fad0d790e8f9 (old id 4659232)
date added to LUP
2014-10-01 07:25:21
date last changed
2017-10-22 03:16:14
@article{539d9476-62b7-47aa-8b0d-fad0d790e8f9,
  abstract     = {Introduction. Both short and long sleep duration may increase risk of type 2 diabetes (diabetes). We studied if short and long sleep durations were associated with insulin resistance (IR) and insulin secretion in individuals without diabetes, and if the associations remained after we excluded individuals who reported more frequent and severe complaints of sleep apnea and insomnia. Participants and methods. An oral glucose tolerance test (OGTT) was performed for 722 adults without diabetes. Indices of IR and insulin secretion were calculated. Sleep duration and complaints of sleep apnea and insomnia were self-reported. Results. In comparison to average sleepers (6 - 9 h/night), short sleepers (&lt; 6 h/night) had higher 120-min insulin and AUC glucose, and long sleepers (&gt;= 9 h/night) had higher fasting and 120-min insulin, 120-min glucose, and HOMA(IR) and lower Insulin Sensitivity Index. After adjusting for confounders and after excluding individuals who reported more frequent and severe complaints of sleep apnea and insomnia, long sleep duration remained significantly associated with IR and insulin secretion. Discussion. Long but not short sleep duration is associated with IR and insulin secretion in individuals without diabetes whether or not accompanied by sleep complaints. Long sleepers may benefit from targeted preventions and interventions that aim at reducing risk of future diabetes.},
  author       = {Pyykkonen, Antti-Jussi and Isomaa, Bo and Pesonen, Anu-Katriina and Eriksson, Johan G. and Groop, Leif and Tuomi, Tiinamaija and Raikkonen, Katri},
  issn         = {1365-2060},
  keyword      = {Insulin resistance,sleep complaints,sleep duration},
  language     = {eng},
  number       = {5},
  pages        = {324--329},
  publisher    = {Informa Healthcare},
  series       = {Annals of Medicine},
  title        = {Sleep duration and insulin resistance in individuals without type 2 diabetes: The PPP-Botnia Study},
  url          = {http://dx.doi.org/10.3109/07853890.2014.902226},
  volume       = {46},
  year         = {2014},
}