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Influence of pH-dependent aquatic toxicity of ionizable pharmaceuticals on risk assessments over environmental pH ranges.

Boström, Marja LU and Berglund, Olof LU (2015) In Water Research 72(Online 6 September 2014). p.154-161
Abstract
Due to variation in pH, ionizable pharmaceuticals entering aquatic environments experience different degrees of ionization, which may affect toxicity. Using data from toxicity testing at only neutral pH may potentially under- or overestimate actual toxicity at pH ranges found in natural aquatic environments. Here we show relative pH-dependent acute toxicity to Daphnia magna for the pharmaceutical weak bases fluoxetine and sertraline, as well as the weak acids naproxen, diclofenac, ibuprofen and ketoprofen. A probabilistic modelling approach using the pH-dependent toxicity data for D. magna and an environmental pH distribution based on over 4000 European running waters from 21 countries predicted that environmental toxicity for the weak... (More)
Due to variation in pH, ionizable pharmaceuticals entering aquatic environments experience different degrees of ionization, which may affect toxicity. Using data from toxicity testing at only neutral pH may potentially under- or overestimate actual toxicity at pH ranges found in natural aquatic environments. Here we show relative pH-dependent acute toxicity to Daphnia magna for the pharmaceutical weak bases fluoxetine and sertraline, as well as the weak acids naproxen, diclofenac, ibuprofen and ketoprofen. A probabilistic modelling approach using the pH-dependent toxicity data for D. magna and an environmental pH distribution based on over 4000 European running waters from 21 countries predicted that environmental toxicity for the weak bases may be underestimated if pH 7 was assumed. The model predicted median underestimation by a factor of 3, with 90% of the model results ranging from 1 to 6. Consequently, due to the slightly basic nature of the European running waters, weak acid toxicity may be overestimated by a factor of 2. Predicted median toxicity was 0.5 of that assuming pH 7 with 90% of the results ranging from 0.03 to 5. Because aquatic pH exhibits large variation both within and between countries, we advise the use of site-specific risk assessments for ionizable pharmaceuticals in making informed water management decisions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Water Research
volume
72
issue
Online 6 September 2014
pages
154 - 161
publisher
Elsevier
external identifiers
  • pmid:25262444
  • wos:000353605000010
  • scopus:84926300995
ISSN
1879-2448
DOI
10.1016/j.watres.2014.08.040
language
English
LU publication?
yes
id
ffdc6c43-50bc-4a5a-b40a-adbe720f6732 (old id 4690829)
date added to LUP
2014-10-09 12:38:00
date last changed
2017-11-12 03:09:39
@article{ffdc6c43-50bc-4a5a-b40a-adbe720f6732,
  abstract     = {Due to variation in pH, ionizable pharmaceuticals entering aquatic environments experience different degrees of ionization, which may affect toxicity. Using data from toxicity testing at only neutral pH may potentially under- or overestimate actual toxicity at pH ranges found in natural aquatic environments. Here we show relative pH-dependent acute toxicity to Daphnia magna for the pharmaceutical weak bases fluoxetine and sertraline, as well as the weak acids naproxen, diclofenac, ibuprofen and ketoprofen. A probabilistic modelling approach using the pH-dependent toxicity data for D. magna and an environmental pH distribution based on over 4000 European running waters from 21 countries predicted that environmental toxicity for the weak bases may be underestimated if pH 7 was assumed. The model predicted median underestimation by a factor of 3, with 90% of the model results ranging from 1 to 6. Consequently, due to the slightly basic nature of the European running waters, weak acid toxicity may be overestimated by a factor of 2. Predicted median toxicity was 0.5 of that assuming pH 7 with 90% of the results ranging from 0.03 to 5. Because aquatic pH exhibits large variation both within and between countries, we advise the use of site-specific risk assessments for ionizable pharmaceuticals in making informed water management decisions.},
  author       = {Boström, Marja and Berglund, Olof},
  issn         = {1879-2448},
  language     = {eng},
  number       = {Online 6 September 2014},
  pages        = {154--161},
  publisher    = {Elsevier},
  series       = {Water Research},
  title        = {Influence of pH-dependent aquatic toxicity of ionizable pharmaceuticals on risk assessments over environmental pH ranges.},
  url          = {http://dx.doi.org/10.1016/j.watres.2014.08.040},
  volume       = {72},
  year         = {2015},
}