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Regional specialization within the intestinal immune system.

Mowat, Allan LU and Agace, William LU (2014) In Nature Reviews. Immunology 14(10). p.667-685
Abstract
The intestine represents the largest compartment of the immune system. It is continually exposed to antigens and immunomodulatory agents from the diet and the commensal microbiota, and it is the port of entry for many clinically important pathogens. Intestinal immune processes are also increasingly implicated in controlling disease development elsewhere in the body. In this Review, we detail the anatomical and physiological distinctions that are observed in the small and large intestines, and we suggest how these may account for the diversity in the immune apparatus that is seen throughout the intestine. We describe how the distribution of innate, adaptive and innate-like immune cells varies in different segments of the intestine and... (More)
The intestine represents the largest compartment of the immune system. It is continually exposed to antigens and immunomodulatory agents from the diet and the commensal microbiota, and it is the port of entry for many clinically important pathogens. Intestinal immune processes are also increasingly implicated in controlling disease development elsewhere in the body. In this Review, we detail the anatomical and physiological distinctions that are observed in the small and large intestines, and we suggest how these may account for the diversity in the immune apparatus that is seen throughout the intestine. We describe how the distribution of innate, adaptive and innate-like immune cells varies in different segments of the intestine and discuss the environmental factors that may influence this. Finally, we consider the implications of regional immune specialization for inflammatory disease in the intestine. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews. Immunology
volume
14
issue
10
pages
667 - 685
publisher
Nature Publishing Group
external identifiers
  • pmid:25234148
  • wos:000342860200009
  • scopus:84921786777
ISSN
1474-1741
DOI
10.1038/nri3738
language
English
LU publication?
yes
id
ddf0cc73-4249-4293-9530-d550c8b45d56 (old id 4691267)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25234148?dopt=Abstract
date added to LUP
2014-10-07 20:49:51
date last changed
2017-11-19 03:17:02
@article{ddf0cc73-4249-4293-9530-d550c8b45d56,
  abstract     = {The intestine represents the largest compartment of the immune system. It is continually exposed to antigens and immunomodulatory agents from the diet and the commensal microbiota, and it is the port of entry for many clinically important pathogens. Intestinal immune processes are also increasingly implicated in controlling disease development elsewhere in the body. In this Review, we detail the anatomical and physiological distinctions that are observed in the small and large intestines, and we suggest how these may account for the diversity in the immune apparatus that is seen throughout the intestine. We describe how the distribution of innate, adaptive and innate-like immune cells varies in different segments of the intestine and discuss the environmental factors that may influence this. Finally, we consider the implications of regional immune specialization for inflammatory disease in the intestine.},
  author       = {Mowat, Allan and Agace, William},
  issn         = {1474-1741},
  language     = {eng},
  number       = {10},
  pages        = {667--685},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews. Immunology},
  title        = {Regional specialization within the intestinal immune system.},
  url          = {http://dx.doi.org/10.1038/nri3738},
  volume       = {14},
  year         = {2014},
}