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Does inbreeding affect gene expression in birds?

Hansson, Bengt LU ; Naurin, Sara LU and Hasselquist, Dennis LU (2014) In Biology Letters 10(9).
Abstract
Inbreeding increases homozygosity, exposes genome-wide recessive deleterious alleles and often reduces fitness. The physiological and reproductive consequences of inbreeding may be manifested already during gene regulation, but the degree to which inbreeding influences gene expression is unknown in most organisms, including in birds. To evaluate the pattern of inbreeding-affected gene expression over the genome and in relation to sex, we performed a transcriptome-wide gene expression (10 695 genes) study of brain tissue of 10-day-old inbred and outbred, male and female zebra finches. We found significantly lower gene expression in females compared with males at Z-linked genes, confirming that dosage compensation is incomplete in female... (More)
Inbreeding increases homozygosity, exposes genome-wide recessive deleterious alleles and often reduces fitness. The physiological and reproductive consequences of inbreeding may be manifested already during gene regulation, but the degree to which inbreeding influences gene expression is unknown in most organisms, including in birds. To evaluate the pattern of inbreeding-affected gene expression over the genome and in relation to sex, we performed a transcriptome-wide gene expression (10 695 genes) study of brain tissue of 10-day-old inbred and outbred, male and female zebra finches. We found significantly lower gene expression in females compared with males at Z-linked genes, confirming that dosage compensation is incomplete in female birds. However, inbreeding did not affect gene expression at autosomal or sex-linked genes, neither in males nor in females. Analyses of single genes again found a clear sex-biased expression at Z-linked genes, whereas only a single gene was significantly affected by inbreeding. The weak effect of inbreeding on gene expression in zebra finches contrasts to the situation, for example, in Drosophila where inbreeding has been found to influence gene expression more generally and at stress-related genes in particular. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biology Letters
volume
10
issue
9
publisher
Royal Society
external identifiers
  • pmid:25232028
  • wos:000341935400006
  • scopus:84929516975
ISSN
1744-9561
DOI
10.1098/rsbl.2014.0648
project
BECC
Inbreeding and inbreeding depression
language
English
LU publication?
yes
id
4de0d01b-77ec-4c56-a13b-ec3820796ce6 (old id 4691310)
date added to LUP
2014-10-08 13:36:19
date last changed
2017-01-01 03:11:30
@article{4de0d01b-77ec-4c56-a13b-ec3820796ce6,
  abstract     = {Inbreeding increases homozygosity, exposes genome-wide recessive deleterious alleles and often reduces fitness. The physiological and reproductive consequences of inbreeding may be manifested already during gene regulation, but the degree to which inbreeding influences gene expression is unknown in most organisms, including in birds. To evaluate the pattern of inbreeding-affected gene expression over the genome and in relation to sex, we performed a transcriptome-wide gene expression (10 695 genes) study of brain tissue of 10-day-old inbred and outbred, male and female zebra finches. We found significantly lower gene expression in females compared with males at Z-linked genes, confirming that dosage compensation is incomplete in female birds. However, inbreeding did not affect gene expression at autosomal or sex-linked genes, neither in males nor in females. Analyses of single genes again found a clear sex-biased expression at Z-linked genes, whereas only a single gene was significantly affected by inbreeding. The weak effect of inbreeding on gene expression in zebra finches contrasts to the situation, for example, in Drosophila where inbreeding has been found to influence gene expression more generally and at stress-related genes in particular.},
  articleno    = {20140648},
  author       = {Hansson, Bengt and Naurin, Sara and Hasselquist, Dennis},
  issn         = {1744-9561},
  language     = {eng},
  number       = {9},
  publisher    = {Royal Society},
  series       = {Biology Letters},
  title        = {Does inbreeding affect gene expression in birds?},
  url          = {http://dx.doi.org/10.1098/rsbl.2014.0648},
  volume       = {10},
  year         = {2014},
}