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Amphiphilic γ-PGA nanoparticles administered on rat middle ear mucosa produce adjuvant-like immunostimulation in vivo.

Nilsson, Johan S LU ; Broos, Sissela; Akagi, Takami; Akashi, Mitsuru; Hermansson, Ann LU ; Cayé-Thomasen, Per; Lindstedt, Malin and Greiff, Lennart LU (2014) In Acta Oto-Laryngologica 134(10). p.1034-1041
Abstract
Abstract Conclusion: Amphiphilic biodegradable nanoparticles (NPs) composed of poly(γ-glutamic acid) conjugated with L-phenylalanine ethylester (γ-PGA-Phe NPs) applied on the rat middle ear mucosa produce an inflammatory type 1 response. The observation is of relevance for the use of γ-PGA-Phe NPs as a concomitant antigen delivery system and adjuvant measure in the context of vaccinations.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oto-Laryngologica
volume
134
issue
10
pages
1034 - 1041
publisher
Taylor & Francis
external identifiers
  • pmid:25220726
  • wos:000342204900008
  • scopus:84907166266
ISSN
1651-2251
DOI
10.3109/00016489.2014.918278
language
English
LU publication?
yes
id
39b7548b-589b-4254-b9d0-2fdc8859ba8f (old id 4691522)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25220726?dopt=Abstract
date added to LUP
2014-10-07 17:54:07
date last changed
2017-01-01 03:25:52
@article{39b7548b-589b-4254-b9d0-2fdc8859ba8f,
  abstract     = {Abstract Conclusion: Amphiphilic biodegradable nanoparticles (NPs) composed of poly(γ-glutamic acid) conjugated with L-phenylalanine ethylester (γ-PGA-Phe NPs) applied on the rat middle ear mucosa produce an inflammatory type 1 response. The observation is of relevance for the use of γ-PGA-Phe NPs as a concomitant antigen delivery system and adjuvant measure in the context of vaccinations.},
  author       = {Nilsson, Johan S and Broos, Sissela and Akagi, Takami and Akashi, Mitsuru and Hermansson, Ann and Cayé-Thomasen, Per and Lindstedt, Malin and Greiff, Lennart},
  issn         = {1651-2251},
  language     = {eng},
  number       = {10},
  pages        = {1034--1041},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {Amphiphilic γ-PGA nanoparticles administered on rat middle ear mucosa produce adjuvant-like immunostimulation in vivo.},
  url          = {http://dx.doi.org/10.3109/00016489.2014.918278},
  volume       = {134},
  year         = {2014},
}