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Amphiphilic γ-PGA nanoparticles administered on rat middle ear mucosa produce adjuvant-like immunostimulation in vivo.

Nilsson, Johan S LU ; Broos, Sissela ; Akagi, Takami ; Akashi, Mitsuru ; Hermansson, Ann LU ; Cayé-Thomasen, Per ; Lindstedt, Malin and Greiff, Lennart LU (2014) In Acta Oto-Laryngologica 134(10). p.1034-1041
Abstract
Abstract Conclusion: Amphiphilic biodegradable nanoparticles (NPs) composed of poly(γ-glutamic acid) conjugated with L-phenylalanine ethylester (γ-PGA-Phe NPs) applied on the rat middle ear mucosa produce an inflammatory type 1 response. The observation is of relevance for the use of γ-PGA-Phe NPs as a concomitant antigen delivery system and adjuvant measure in the context of vaccinations.
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oto-Laryngologica
volume
134
issue
10
pages
1034 - 1041
publisher
Taylor & Francis
external identifiers
  • pmid:25220726
  • wos:000342204900008
  • scopus:84907166266
  • pmid:25220726
ISSN
1651-2251
DOI
10.3109/00016489.2014.918278
language
English
LU publication?
yes
id
39b7548b-589b-4254-b9d0-2fdc8859ba8f (old id 4691522)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25220726?dopt=Abstract
date added to LUP
2016-04-01 10:16:19
date last changed
2022-01-25 21:33:47
@article{39b7548b-589b-4254-b9d0-2fdc8859ba8f,
  abstract     = {{Abstract Conclusion: Amphiphilic biodegradable nanoparticles (NPs) composed of poly(γ-glutamic acid) conjugated with L-phenylalanine ethylester (γ-PGA-Phe NPs) applied on the rat middle ear mucosa produce an inflammatory type 1 response. The observation is of relevance for the use of γ-PGA-Phe NPs as a concomitant antigen delivery system and adjuvant measure in the context of vaccinations.}},
  author       = {{Nilsson, Johan S and Broos, Sissela and Akagi, Takami and Akashi, Mitsuru and Hermansson, Ann and Cayé-Thomasen, Per and Lindstedt, Malin and Greiff, Lennart}},
  issn         = {{1651-2251}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1034--1041}},
  publisher    = {{Taylor & Francis}},
  series       = {{Acta Oto-Laryngologica}},
  title        = {{Amphiphilic γ-PGA nanoparticles administered on rat middle ear mucosa produce adjuvant-like immunostimulation in vivo.}},
  url          = {{http://dx.doi.org/10.3109/00016489.2014.918278}},
  doi          = {{10.3109/00016489.2014.918278}},
  volume       = {{134}},
  year         = {{2014}},
}