Glycoprotein 340 and sialic acid in minor-gland and whole saliva of children, adolescents, and adults.
(2011) In European Journal of Oral Sciences 119(6). p.435-440- Abstract
- Glycoprotein 340 (gp-340) is a bacterial-binding glycoprotein found in major-gland and minor-gland saliva. Sialic acid, a common terminal structure of salivary glycoproteins, interacts with microorganisms and host ligands, as well as with free radicals. This study investigated the contents of gp-340 and sialic acid in minor-gland saliva and whole saliva of children (3 yr of age), adolescents (14 yr of age), and adults (20-25 yr of age). Labial-gland saliva and buccal-gland saliva were collected on filter paper, and unstimulated whole saliva was collected by draining into a tube. The relative amount of gp-340 and sialic acid was determined by ELISA and by enzyme-linked lectin assay (ELLA), respectively. In minor-gland saliva, no... (More)
- Glycoprotein 340 (gp-340) is a bacterial-binding glycoprotein found in major-gland and minor-gland saliva. Sialic acid, a common terminal structure of salivary glycoproteins, interacts with microorganisms and host ligands, as well as with free radicals. This study investigated the contents of gp-340 and sialic acid in minor-gland saliva and whole saliva of children (3 yr of age), adolescents (14 yr of age), and adults (20-25 yr of age). Labial-gland saliva and buccal-gland saliva were collected on filter paper, and unstimulated whole saliva was collected by draining into a tube. The relative amount of gp-340 and sialic acid was determined by ELISA and by enzyme-linked lectin assay (ELLA), respectively. In minor-gland saliva, no statistically significant differences in gp-340 and sialic acid were seen between the age-groups. Among adults, significantly lower amounts of gp-340 and sialic acid were seen in labial saliva compared with buccal saliva. In whole saliva, the amount of gp-340 was significantly lower among adults compared with children. No differences between genders were seen. Stable content of gp-340 and sialic acid in minor-gland saliva across the age-groups, and a higher content of gp-340 in the whole saliva of the youngest age-group (3-yr-olds) compared with the adult group, may reflect that those components are vital innate factors of immunity in children's saliva. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2220437
- author
- Sonesson, Mikael ; Ericson, Dan ; Kinnby, Bertil and Wickström, Claes LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Oral Sciences
- volume
- 119
- issue
- 6
- pages
- 435 - 440
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:22112028
- scopus:82155165897
- pmid:22112028
- ISSN
- 0909-8836
- DOI
- 10.1111/j.1600-0722.2011.00879.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Mucosal biology (013212033)
- id
- 46b07819-59f7-48b4-a367-0d3fb9de47de (old id 2220437)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22112028?dopt=Abstract
- date added to LUP
- 2016-04-04 07:13:50
- date last changed
- 2022-01-29 01:55:04
@article{46b07819-59f7-48b4-a367-0d3fb9de47de,
abstract = {{Glycoprotein 340 (gp-340) is a bacterial-binding glycoprotein found in major-gland and minor-gland saliva. Sialic acid, a common terminal structure of salivary glycoproteins, interacts with microorganisms and host ligands, as well as with free radicals. This study investigated the contents of gp-340 and sialic acid in minor-gland saliva and whole saliva of children (3 yr of age), adolescents (14 yr of age), and adults (20-25 yr of age). Labial-gland saliva and buccal-gland saliva were collected on filter paper, and unstimulated whole saliva was collected by draining into a tube. The relative amount of gp-340 and sialic acid was determined by ELISA and by enzyme-linked lectin assay (ELLA), respectively. In minor-gland saliva, no statistically significant differences in gp-340 and sialic acid were seen between the age-groups. Among adults, significantly lower amounts of gp-340 and sialic acid were seen in labial saliva compared with buccal saliva. In whole saliva, the amount of gp-340 was significantly lower among adults compared with children. No differences between genders were seen. Stable content of gp-340 and sialic acid in minor-gland saliva across the age-groups, and a higher content of gp-340 in the whole saliva of the youngest age-group (3-yr-olds) compared with the adult group, may reflect that those components are vital innate factors of immunity in children's saliva.}},
author = {{Sonesson, Mikael and Ericson, Dan and Kinnby, Bertil and Wickström, Claes}},
issn = {{0909-8836}},
language = {{eng}},
number = {{6}},
pages = {{435--440}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Oral Sciences}},
title = {{Glycoprotein 340 and sialic acid in minor-gland and whole saliva of children, adolescents, and adults.}},
url = {{http://dx.doi.org/10.1111/j.1600-0722.2011.00879.x}},
doi = {{10.1111/j.1600-0722.2011.00879.x}},
volume = {{119}},
year = {{2011}},
}