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A structural model for the membrane-integral domain of succinate:quinone oxidoreductases

Hägerhäll, Cecilia LU and Hederstedt, Lars LU (1996) In FEBS Letters
Abstract
Many succinate:quinone oxidoreductases in bacteria and mitochondria, i.e, succinate:quinone reductases and fumarate reductases, contain in the membrane anchor a cytochrome b whose structure and function is poorly understood, Based on biochemical data and polypeptide sequence information, we show that the anchors in different organisms are related despite an apparent diversity in polypeptide and heme composition, A general structural model for the membrane-integral domain of the anchors is proposed, It is an antiparallel four-helix bundle with a novel arrangement of hexa-coordinated protoheme M. The structure can be applied to a larger group of membrane-integral cytochromes of b-type and has evolutionary and functional implications.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
FEBS Letters
publisher
Wiley-Blackwell
ISSN
1873-3468
DOI
10.1016/0014-5793(96)00529-7
language
English
LU publication?
yes
id
47042834-c4ab-4be6-8f19-4d59da8b83b8
date added to LUP
2017-07-18 10:04:12
date last changed
2017-08-14 11:35:09
@article{47042834-c4ab-4be6-8f19-4d59da8b83b8,
  abstract     = {Many succinate:quinone oxidoreductases in bacteria and mitochondria, i.e, succinate:quinone reductases and fumarate reductases, contain in the membrane anchor a cytochrome b whose structure and function is poorly understood, Based on biochemical data and polypeptide sequence information, we show that the anchors in different organisms are related despite an apparent diversity in polypeptide and heme composition, A general structural model for the membrane-integral domain of the anchors is proposed, It is an antiparallel four-helix bundle with a novel arrangement of hexa-coordinated protoheme M. The structure can be applied to a larger group of membrane-integral cytochromes of b-type and has evolutionary and functional implications.},
  author       = {Hägerhäll, Cecilia and Hederstedt, Lars},
  issn         = {1873-3468},
  language     = {eng},
  publisher    = {Wiley-Blackwell},
  series       = {FEBS Letters},
  title        = {A structural model for the membrane-integral domain of succinate:quinone oxidoreductases},
  url          = {http://dx.doi.org/10.1016/0014-5793(96)00529-7 },
  year         = {1996},
}