A structural model for the membrane-integral domain of succinate:quinone oxidoreductases
(1996) In FEBS Letters- Abstract
- Many succinate:quinone oxidoreductases in bacteria and mitochondria, i.e, succinate:quinone reductases and fumarate reductases, contain in the membrane anchor a cytochrome b whose structure and function is poorly understood, Based on biochemical data and polypeptide sequence information, we show that the anchors in different organisms are related despite an apparent diversity in polypeptide and heme composition, A general structural model for the membrane-integral domain of the anchors is proposed, It is an antiparallel four-helix bundle with a novel arrangement of hexa-coordinated protoheme M. The structure can be applied to a larger group of membrane-integral cytochromes of b-type and has evolutionary and functional implications.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/47042834-c4ab-4be6-8f19-4d59da8b83b8
- author
- Hägerhäll, Cecilia LU and Hederstedt, Lars LU
- organization
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- subject
- in
- FEBS Letters
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0030600143
- ISSN
- 1873-3468
- DOI
- 10.1016/0014-5793(96)00529-7
- language
- English
- LU publication?
- yes
- id
- 47042834-c4ab-4be6-8f19-4d59da8b83b8
- date added to LUP
- 2017-07-18 10:04:12
- date last changed
- 2022-01-30 21:32:23
@article{47042834-c4ab-4be6-8f19-4d59da8b83b8, abstract = {{Many succinate:quinone oxidoreductases in bacteria and mitochondria, i.e, succinate:quinone reductases and fumarate reductases, contain in the membrane anchor a cytochrome b whose structure and function is poorly understood, Based on biochemical data and polypeptide sequence information, we show that the anchors in different organisms are related despite an apparent diversity in polypeptide and heme composition, A general structural model for the membrane-integral domain of the anchors is proposed, It is an antiparallel four-helix bundle with a novel arrangement of hexa-coordinated protoheme M. The structure can be applied to a larger group of membrane-integral cytochromes of b-type and has evolutionary and functional implications.}}, author = {{Hägerhäll, Cecilia and Hederstedt, Lars}}, issn = {{1873-3468}}, language = {{eng}}, publisher = {{Wiley-Blackwell}}, series = {{FEBS Letters}}, title = {{A structural model for the membrane-integral domain of succinate:quinone oxidoreductases}}, url = {{http://dx.doi.org/10.1016/0014-5793(96)00529-7}}, doi = {{10.1016/0014-5793(96)00529-7}}, year = {{1996}}, }