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The impact of male overweight on semen quality and outcome of assisted reproduction

Thomsen, Lise; Humaidan, Peter; Bungum, Leif and Bungum, Mona LU (2014) In Asian Journal of Andrology 16(5). p.749-754
Abstract
It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass index (BMI) on semen quality and the outcome of assisted reproductive technology (ART). The aim of this study was to investigate whether increased male BMI affects sperm quality and the outcome of assisted reproduction in couples with an overweight or obese man and a non-obese partner. Data was prospectively collected from 612 infertile couples undergoing ART at a Danish fertility center. Self-reported information on paternal height and weight were recorded and BMI was calculated. The men were divided into four BMI categories:... (More)
It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass index (BMI) on semen quality and the outcome of assisted reproductive technology (ART). The aim of this study was to investigate whether increased male BMI affects sperm quality and the outcome of assisted reproduction in couples with an overweight or obese man and a non-obese partner. Data was prospectively collected from 612 infertile couples undergoing ART at a Danish fertility center. Self-reported information on paternal height and weight were recorded and BMI was calculated. The men were divided into four BMI categories: underweight BMI < 20 kg m(2) , normal BMI 20-24.9 kg m(2) , overweight BMI 25-29.9 kg m(2) and obese BMI > 30 kg m(2) . Conventional semen analysis was performed according to the World Health Organization guideline and sperm DNA integrity was analyzed by the Sperm Chromatin Structure Assay (SCSA). No statistically significant effect of male BMI was seen on conventional semen parameters (sperm concentration, total sperm count, seminal volume and motility) or on SCSA-results. Furthermore, the outcome of ART regarding fertilization rate, number of good quality embryos (GQE ), implantation and pregnancy outcome was not influenced by the increasing male BMI. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
assisted reproductive technology, body mass index, male obesity, sperm, chromatin structure assay, sperm quality
in
Asian Journal of Andrology
volume
16
issue
5
pages
749 - 754
publisher
Nature Publishing Group
external identifiers
  • wos:000341847200021
  • scopus:84907013476
ISSN
1008-682X
DOI
10.4103/1008-682X.125398
language
English
LU publication?
yes
id
259d03ca-a5dc-4e17-bbba-bfad6004ccb7 (old id 4709968)
date added to LUP
2014-11-03 07:14:56
date last changed
2017-10-01 03:01:13
@article{259d03ca-a5dc-4e17-bbba-bfad6004ccb7,
  abstract     = {It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass index (BMI) on semen quality and the outcome of assisted reproductive technology (ART). The aim of this study was to investigate whether increased male BMI affects sperm quality and the outcome of assisted reproduction in couples with an overweight or obese man and a non-obese partner. Data was prospectively collected from 612 infertile couples undergoing ART at a Danish fertility center. Self-reported information on paternal height and weight were recorded and BMI was calculated. The men were divided into four BMI categories: underweight BMI &lt; 20 kg m(2) , normal BMI 20-24.9 kg m(2) , overweight BMI 25-29.9 kg m(2) and obese BMI &gt; 30 kg m(2) . Conventional semen analysis was performed according to the World Health Organization guideline and sperm DNA integrity was analyzed by the Sperm Chromatin Structure Assay (SCSA). No statistically significant effect of male BMI was seen on conventional semen parameters (sperm concentration, total sperm count, seminal volume and motility) or on SCSA-results. Furthermore, the outcome of ART regarding fertilization rate, number of good quality embryos (GQE ), implantation and pregnancy outcome was not influenced by the increasing male BMI.},
  author       = {Thomsen, Lise and Humaidan, Peter and Bungum, Leif and Bungum, Mona},
  issn         = {1008-682X},
  keyword      = {assisted reproductive technology,body mass index,male obesity,sperm,chromatin structure assay,sperm quality},
  language     = {eng},
  number       = {5},
  pages        = {749--754},
  publisher    = {Nature Publishing Group},
  series       = {Asian Journal of Andrology},
  title        = {The impact of male overweight on semen quality and outcome of assisted reproduction},
  url          = {http://dx.doi.org/10.4103/1008-682X.125398},
  volume       = {16},
  year         = {2014},
}