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Production of protein HC by human fetal liver explants

Tejler, L ; Eriksson, S LU ; Grubb, A LU orcid and Åstedt, B (1978) In Biochimica et Biophysica Acta 542(3). p.14-506
Abstract

Human fetal lever explants were found to secrete protein HC into the medium in molar amounts comparable to those of albumin, alpha 1-antitrypsin and orosomucoid. Incorporation of a radioactive amino acid from the medium into the secreted protein HC demonstrated de novo synthesis. The secreted protein HC had the same size and electrophoretic mobility as protein HC of plasma and urine and gave a reaction of immunochemical identity with the protein in these biological fluids.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alpha-Globulins, Antigens/analysis, Culture Media, Glycoproteins/biosynthesis, Humans, Liver/embryology, Molecular Weight, Organ Culture Techniques
in
Biochimica et Biophysica Acta
volume
542
issue
3
pages
14 - 506
publisher
Elsevier
external identifiers
  • scopus:0018116013
  • pmid:687667
ISSN
0006-3002
DOI
10.1016/0304-4165(78)90380-x
language
English
LU publication?
yes
id
470c414e-0c20-486e-839c-e39ae14e7e52
date added to LUP
2021-10-16 19:29:06
date last changed
2024-01-12 02:55:32
@article{470c414e-0c20-486e-839c-e39ae14e7e52,
  abstract     = {{<p>Human fetal lever explants were found to secrete protein HC into the medium in molar amounts comparable to those of albumin, alpha 1-antitrypsin and orosomucoid. Incorporation of a radioactive amino acid from the medium into the secreted protein HC demonstrated de novo synthesis. The secreted protein HC had the same size and electrophoretic mobility as protein HC of plasma and urine and gave a reaction of immunochemical identity with the protein in these biological fluids.</p>}},
  author       = {{Tejler, L and Eriksson, S and Grubb, A and Åstedt, B}},
  issn         = {{0006-3002}},
  keywords     = {{Alpha-Globulins; Antigens/analysis; Culture Media; Glycoproteins/biosynthesis; Humans; Liver/embryology; Molecular Weight; Organ Culture Techniques}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{14--506}},
  publisher    = {{Elsevier}},
  series       = {{Biochimica et Biophysica Acta}},
  title        = {{Production of protein HC by human fetal liver explants}},
  url          = {{http://dx.doi.org/10.1016/0304-4165(78)90380-x}},
  doi          = {{10.1016/0304-4165(78)90380-x}},
  volume       = {{542}},
  year         = {{1978}},
}