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Diagnostic value of MRS-quantified brain tissue lactate level in identifying children with mitochondrial disorders

Lunsing, Roelineke J. ; Strating, Kim ; de Koning, Tom J. LU and Sijens, Paul E. (2017) In European Radiology 27(3). p.976-984
Abstract

Objectives: Magnetic resonance spectroscopy (MRS) of children with or without neurometabolic disease is used for the first time for quantitative assessment of brain tissue lactate signals, to elaborate on previous suggestions of MRS-detected lactate as a marker of mitochondrial disease. Methods: Multivoxel MRS of a transverse plane of brain tissue cranial to the ventricles was performed in 88 children suspected of having neurometabolic disease, divided into ‘definite’ (n = 17, ≥1 major criteria), ‘probable’ (n = 10, ≥2 minor criteria), ‘possible’ (n = 17, 1 minor criterion) and ‘unlikely’ mitochondrial disease (n = 44, none of the criteria). Lactate levels, expressed in standardized arbitrary units or relative to creatine, were derived... (More)

Objectives: Magnetic resonance spectroscopy (MRS) of children with or without neurometabolic disease is used for the first time for quantitative assessment of brain tissue lactate signals, to elaborate on previous suggestions of MRS-detected lactate as a marker of mitochondrial disease. Methods: Multivoxel MRS of a transverse plane of brain tissue cranial to the ventricles was performed in 88 children suspected of having neurometabolic disease, divided into ‘definite’ (n = 17, ≥1 major criteria), ‘probable’ (n = 10, ≥2 minor criteria), ‘possible’ (n = 17, 1 minor criterion) and ‘unlikely’ mitochondrial disease (n = 44, none of the criteria). Lactate levels, expressed in standardized arbitrary units or relative to creatine, were derived from summed signals from all voxels. Ten ‘unlikely’ children with a normal neurological exam served as the MRS reference subgroup. For 61 of 88 children, CSF lactate values were obtained. Results: MRS lactate level (>12 arbitrary units) and the lactate-to-creatine ratio (L/Cr >0.22) differed significantly between the definite and the unlikely group (p = 0.015 and p = 0.001, respectively). MRS L/Cr also differentiated between the probable and the MRS reference subgroup (p = 0.03). No significant group differences were found for CSF lactate. Conclusion: MRS-quantified brain tissue lactate levels can serve as diagnostic marker for identifying mitochondrial disease in children. Key points: • MRS-detected brain tissue lactate levels can be quantified. • MRS lactate and lactate/Cr are increased in children with mitochondrial disease. • CSF lactate is less suitable as marker of mitochondrial disease.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cerebrospinal fluid, Lactate, Magnetic resonance, Mitochondri, MR spectroscopy
in
European Radiology
volume
27
issue
3
pages
9 pages
publisher
Springer
external identifiers
  • pmid:27271921
  • scopus:84976307726
ISSN
0938-7994
DOI
10.1007/s00330-016-4454-8
language
English
LU publication?
no
id
4719fe24-71a1-41a7-942a-9ab857f433db
date added to LUP
2020-02-26 09:53:09
date last changed
2024-05-15 07:59:38
@article{4719fe24-71a1-41a7-942a-9ab857f433db,
  abstract     = {{<p>Objectives: Magnetic resonance spectroscopy (MRS) of children with or without neurometabolic disease is used for the first time for quantitative assessment of brain tissue lactate signals, to elaborate on previous suggestions of MRS-detected lactate as a marker of mitochondrial disease. Methods: Multivoxel MRS of a transverse plane of brain tissue cranial to the ventricles was performed in 88 children suspected of having neurometabolic disease, divided into ‘definite’ (n = 17, ≥1 major criteria), ‘probable’ (n = 10, ≥2 minor criteria), ‘possible’ (n = 17, 1 minor criterion) and ‘unlikely’ mitochondrial disease (n = 44, none of the criteria). Lactate levels, expressed in standardized arbitrary units or relative to creatine, were derived from summed signals from all voxels. Ten ‘unlikely’ children with a normal neurological exam served as the MRS reference subgroup. For 61 of 88 children, CSF lactate values were obtained. Results: MRS lactate level (&gt;12 arbitrary units) and the lactate-to-creatine ratio (L/Cr &gt;0.22) differed significantly between the definite and the unlikely group (p = 0.015 and p = 0.001, respectively). MRS L/Cr also differentiated between the probable and the MRS reference subgroup (p = 0.03). No significant group differences were found for CSF lactate. Conclusion: MRS-quantified brain tissue lactate levels can serve as diagnostic marker for identifying mitochondrial disease in children. Key points: • MRS-detected brain tissue lactate levels can be quantified. • MRS lactate and lactate/Cr are increased in children with mitochondrial disease. • CSF lactate is less suitable as marker of mitochondrial disease.</p>}},
  author       = {{Lunsing, Roelineke J. and Strating, Kim and de Koning, Tom J. and Sijens, Paul E.}},
  issn         = {{0938-7994}},
  keywords     = {{Cerebrospinal fluid; Lactate; Magnetic resonance; Mitochondri; MR spectroscopy}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{976--984}},
  publisher    = {{Springer}},
  series       = {{European Radiology}},
  title        = {{Diagnostic value of MRS-quantified brain tissue lactate level in identifying children with mitochondrial disorders}},
  url          = {{http://dx.doi.org/10.1007/s00330-016-4454-8}},
  doi          = {{10.1007/s00330-016-4454-8}},
  volume       = {{27}},
  year         = {{2017}},
}