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The role of tumor location in pancreatic cancer on perioperative outcome and long-term survival

Lennartsson, Philipp LU orcid ; Ansari, Daniel LU and Andersson, Bodil LU orcid (2025) In British Journal of Surgery 112(Issue Suppl 11). p.30-30
Abstract
Introduction
Pancreatic cancer has a low survival. The aim of this study was to analyze the role of tumor location on perioperative outcome and survival.

Method
Data on all patients with resected pancreatic ductal adenocarcinoma (PDAC) identified in the Swedish National Pancreatic and Periampullary Cancer Registry 2010-2020 were included. Tumor locations in the head, body and tail were compared. A multivariable Cox survival analysis was conducted adjusting for age, gender, ASA classification, TNM7 stage, neoadjuvant chemotherapy, R0-status, grade of differentiation and date of operation.

Result
In total, 2355 patients were included, 1834 with tumor in the head, 216 in the body and 305 in the tail. Tumors in... (More)
Introduction
Pancreatic cancer has a low survival. The aim of this study was to analyze the role of tumor location on perioperative outcome and survival.

Method
Data on all patients with resected pancreatic ductal adenocarcinoma (PDAC) identified in the Swedish National Pancreatic and Periampullary Cancer Registry 2010-2020 were included. Tumor locations in the head, body and tail were compared. A multivariable Cox survival analysis was conducted adjusting for age, gender, ASA classification, TNM7 stage, neoadjuvant chemotherapy, R0-status, grade of differentiation and date of operation.

Result
In total, 2355 patients were included, 1834 with tumor in the head, 216 in the body and 305 in the tail. Tumors in the head were more often T3 (72% vs 56% vs 56%, P < 0.001) and had more advanced lymph node involvement, N1 (79% vs 59% vs 50%, P <0.001). Moreover, they more frequently had resection of veins (31% vs 20% vs 8%, P < 0,001) and higher intraoperative bleeding (500 ml vs 350 ml vs 300 ml, P < 0.001). R0 resection was less common in head tumors (45% vs 59% vs 63%, P < 0.001). The unadjusted 5-year survival for tail tumors was twice as high as for head tumors (23% vs 34% vs 46%). In the multivariable adjusted analysis, tumor location in the tail was an independent prognostic factor HR 0.75 (95% CI 0.63-0.89).

Discussion
Tumors in the head of the pancreas had a more advanced stage. Tumor location in the tail was an independent predictor of longer survival. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Surgery
volume
112
issue
Issue Suppl 11
article number
znaf149.107
pages
30 - 30
publisher
Oxford University Press
ISSN
1365-2168
DOI
10.1093/bjs/znaf149.107
language
English
LU publication?
yes
id
472a3e7b-4529-4fd1-ba2c-77a285c98ff3
date added to LUP
2025-09-29 20:55:51
date last changed
2025-09-30 07:34:14
@misc{472a3e7b-4529-4fd1-ba2c-77a285c98ff3,
  abstract     = {{Introduction<br/>Pancreatic cancer has a low survival. The aim of this study was to analyze the role of tumor location on perioperative outcome and survival.<br/><br/>Method<br/>Data on all patients with resected pancreatic ductal adenocarcinoma (PDAC) identified in the Swedish National Pancreatic and Periampullary Cancer Registry 2010-2020 were included. Tumor locations in the head, body and tail were compared. A multivariable Cox survival analysis was conducted adjusting for age, gender, ASA classification, TNM7 stage, neoadjuvant chemotherapy, R0-status, grade of differentiation and date of operation.<br/><br/>Result<br/>In total, 2355 patients were included, 1834 with tumor in the head, 216 in the body and 305 in the tail. Tumors in the head were more often T3 (72% vs 56% vs 56%, P &lt; 0.001) and had more advanced lymph node involvement, N1 (79% vs 59% vs 50%, P &lt;0.001). Moreover, they more frequently had resection of veins (31% vs 20% vs 8%, P &lt; 0,001) and higher intraoperative bleeding (500 ml vs 350 ml vs 300 ml, P &lt; 0.001). R0 resection was less common in head tumors (45% vs 59% vs 63%, P &lt; 0.001). The unadjusted 5-year survival for tail tumors was twice as high as for head tumors (23% vs 34% vs 46%). In the multivariable adjusted analysis, tumor location in the tail was an independent prognostic factor HR 0.75 (95% CI 0.63-0.89).<br/><br/>Discussion<br/>Tumors in the head of the pancreas had a more advanced stage. Tumor location in the tail was an independent predictor of longer survival.}},
  author       = {{Lennartsson, Philipp and Ansari, Daniel and Andersson, Bodil}},
  issn         = {{1365-2168}},
  language     = {{eng}},
  month        = {{08}},
  note         = {{Conference Abstract}},
  number       = {{Issue Suppl 11}},
  pages        = {{30--30}},
  publisher    = {{Oxford University Press}},
  series       = {{British Journal of Surgery}},
  title        = {{The role of tumor location in pancreatic cancer on perioperative outcome and long-term survival}},
  url          = {{http://dx.doi.org/10.1093/bjs/znaf149.107}},
  doi          = {{10.1093/bjs/znaf149.107}},
  volume       = {{112}},
  year         = {{2025}},
}