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Association between sickle cell trait and the prevalence and severity of diabetic retinopathy

Harbi, Majed Al; Khandekar, Rajiv; Kozak, Igor and Schatz, Patrik LU (2016) In PLoS One 11(7).
Abstract

Purpose To determine whether Sickle cell trait (SCT) is associated with an increased severity of diabetic retinopathy. Methods This was a single center retrospective study case control study of 100 eyes of 100 patients with diabetes mellitus (DM) with SCT (SCT group) and 100 eyes of 100 age-matched patients with DM without SCT (control group). The main outcome measure was the difference in the prevalence of sight threatening DR [here defined as diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR)], between the SCT and control groups. Secondary outcome measures included differences in visual acuity, ocular comorbidities, intraocular pressure, glycemic control as assessed by random blood glucose measurement,... (More)

Purpose To determine whether Sickle cell trait (SCT) is associated with an increased severity of diabetic retinopathy. Methods This was a single center retrospective study case control study of 100 eyes of 100 patients with diabetes mellitus (DM) with SCT (SCT group) and 100 eyes of 100 age-matched patients with DM without SCT (control group). The main outcome measure was the difference in the prevalence of sight threatening DR [here defined as diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR)], between the SCT and control groups. Secondary outcome measures included differences in visual acuity, ocular comorbidities, intraocular pressure, glycemic control as assessed by random blood glucose measurement, diabetes duration, nephropathy, hyperlipidemia and hypertension. Results The SCT group had statistically significantly shorter duration of DM (median [25% quartile] 15 [8.3] years versus 20 [14.7] years, respectively)(P

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publication status
published
subject
in
PLoS One
volume
11
issue
7
publisher
Public Library of Science
external identifiers
  • Scopus:84978514909
  • WOS:000379579500099
ISSN
1932-6203
DOI
10.1371/journal.pone.0159215
language
English
LU publication?
yes
id
4731bf7b-afd9-427a-a246-fa833b92c716
date added to LUP
2016-08-02 10:37:46
date last changed
2017-01-01 08:31:19
@article{4731bf7b-afd9-427a-a246-fa833b92c716,
  abstract     = {<p>Purpose To determine whether Sickle cell trait (SCT) is associated with an increased severity of diabetic retinopathy. Methods This was a single center retrospective study case control study of 100 eyes of 100 patients with diabetes mellitus (DM) with SCT (SCT group) and 100 eyes of 100 age-matched patients with DM without SCT (control group). The main outcome measure was the difference in the prevalence of sight threatening DR [here defined as diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR)], between the SCT and control groups. Secondary outcome measures included differences in visual acuity, ocular comorbidities, intraocular pressure, glycemic control as assessed by random blood glucose measurement, diabetes duration, nephropathy, hyperlipidemia and hypertension. Results The SCT group had statistically significantly shorter duration of DM (median [25% quartile] 15 [8.3] years versus 20 [14.7] years, respectively)(P</p>},
  articleno    = {e0159215},
  author       = {Harbi, Majed Al and Khandekar, Rajiv and Kozak, Igor and Schatz, Patrik},
  issn         = {1932-6203},
  language     = {eng},
  month        = {07},
  number       = {7},
  publisher    = {Public Library of Science},
  series       = {PLoS One},
  title        = {Association between sickle cell trait and the prevalence and severity of diabetic retinopathy},
  url          = {http://dx.doi.org/10.1371/journal.pone.0159215},
  volume       = {11},
  year         = {2016},
}