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Lipid composition of the stratum corneum and cutaneous water loss in birds along an aridity gradient

Champagne, Alex M.; Munoz-Garcia, Agusti; Shtayyeh, Tamer; Tieleman, B. Irene; Hegemann, Arne LU ; Clement, Michelle E. and Williams, Joseph B. (2012) In Journal of Experimental Biology 215(24). p.4299-4307
Abstract
Intercellular and covalently bound lipids within the stratum corneum (SC), the outermost layer of the epidermis, are the primary barrier to cutaneous water loss (CWL) in birds. We compared CWL and intercellular SC lipid composition in 20 species of birds from desert and mesic environments. Furthermore, we compared covalently bound lipids with CWL and intercellular lipids in the lark family (Alaudidae). We found that CWL increases in birds from more mesic environments, and this increase was related to changes in intercellular SC lipid composition. The most consistent pattern that emerged was a decrease in the relative amount of cerebrosides as CWL increased, a pattern that is counterintuitive based on studies of mammals with Gaucher... (More)
Intercellular and covalently bound lipids within the stratum corneum (SC), the outermost layer of the epidermis, are the primary barrier to cutaneous water loss (CWL) in birds. We compared CWL and intercellular SC lipid composition in 20 species of birds from desert and mesic environments. Furthermore, we compared covalently bound lipids with CWL and intercellular lipids in the lark family (Alaudidae). We found that CWL increases in birds from more mesic environments, and this increase was related to changes in intercellular SC lipid composition. The most consistent pattern that emerged was a decrease in the relative amount of cerebrosides as CWL increased, a pattern that is counterintuitive based on studies of mammals with Gaucher disease. Although covalently bound lipids in larks did not correlate with CWL, we found that covalently bound cerebrosides correlated positively with intercellular cerebrosides and intercellular cholesterol ester, and intercellular cerebrosides correlated positively with covalently bound free fatty acids. Our results led us to propose a new model for the organization of lipids in the avian SC, in which the sugar moieties of cerebrosides lie outside of intercellular lipid layers, where they may interdigitate with adjacent intercellular cerebrosides or with covalently bound cerebrosides. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebroside, desert, mesic, covalently bound lipid
in
Journal of Experimental Biology
volume
215
issue
24
pages
4299 - 4307
publisher
The Company of Biologists Ltd
external identifiers
  • wos:000311480100013
  • scopus:84876442299
ISSN
1477-9145
DOI
10.1242/jeb.077016
language
English
LU publication?
no
id
8f49d55d-b5f5-4f7b-bd69-f3ec250ab558 (old id 4732060)
date added to LUP
2014-10-30 09:20:48
date last changed
2017-09-03 03:18:05
@article{8f49d55d-b5f5-4f7b-bd69-f3ec250ab558,
  abstract     = {Intercellular and covalently bound lipids within the stratum corneum (SC), the outermost layer of the epidermis, are the primary barrier to cutaneous water loss (CWL) in birds. We compared CWL and intercellular SC lipid composition in 20 species of birds from desert and mesic environments. Furthermore, we compared covalently bound lipids with CWL and intercellular lipids in the lark family (Alaudidae). We found that CWL increases in birds from more mesic environments, and this increase was related to changes in intercellular SC lipid composition. The most consistent pattern that emerged was a decrease in the relative amount of cerebrosides as CWL increased, a pattern that is counterintuitive based on studies of mammals with Gaucher disease. Although covalently bound lipids in larks did not correlate with CWL, we found that covalently bound cerebrosides correlated positively with intercellular cerebrosides and intercellular cholesterol ester, and intercellular cerebrosides correlated positively with covalently bound free fatty acids. Our results led us to propose a new model for the organization of lipids in the avian SC, in which the sugar moieties of cerebrosides lie outside of intercellular lipid layers, where they may interdigitate with adjacent intercellular cerebrosides or with covalently bound cerebrosides.},
  author       = {Champagne, Alex M. and Munoz-Garcia, Agusti and Shtayyeh, Tamer and Tieleman, B. Irene and Hegemann, Arne and Clement, Michelle E. and Williams, Joseph B.},
  issn         = {1477-9145},
  keyword      = {cerebroside,desert,mesic,covalently bound lipid},
  language     = {eng},
  number       = {24},
  pages        = {4299--4307},
  publisher    = {The Company of Biologists Ltd},
  series       = {Journal of Experimental Biology},
  title        = {Lipid composition of the stratum corneum and cutaneous water loss in birds along an aridity gradient},
  url          = {http://dx.doi.org/10.1242/jeb.077016},
  volume       = {215},
  year         = {2012},
}