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Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.

Smith, Gustav LU ; Luk, Kevin ; Schulz, Christina-Alexandra LU ; Engert, James C ; Do, Ron ; Hindy, George LU ; Rukh, Gull LU ; Dufresne, Line ; Almgren, Peter LU and Owens, David S , et al. (2014) In JAMA: The Journal of the American Medical Association 312(17). p.1764-1771
Abstract
Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
JAMA: The Journal of the American Medical Association
volume
312
issue
17
pages
1764 - 1771
publisher
American Medical Association
external identifiers
  • pmid:25344734
  • wos:000344194500014
  • scopus:84908689210
  • pmid:25344734
ISSN
1538-3598
DOI
10.1001/jama.2014.13959
language
English
LU publication?
yes
id
1babbb48-69c4-4bce-b4f2-4ca2ffa8fc4e (old id 4733242)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25344734?dopt=Abstract
date added to LUP
2016-04-01 10:32:13
date last changed
2022-04-20 03:02:06
@article{1babbb48-69c4-4bce-b4f2-4ca2ffa8fc4e,
  abstract     = {{Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression.}},
  author       = {{Smith, Gustav and Luk, Kevin and Schulz, Christina-Alexandra and Engert, James C and Do, Ron and Hindy, George and Rukh, Gull and Dufresne, Line and Almgren, Peter and Owens, David S and Harris, Tamara B and Peloso, Gina M and Kerr, Kathleen F and Wong, Quenna and Smith, Albert V and Budoff, Matthew J and Rotter, Jerome I and Cupples, L Adrienne and Rich, Stephen and Kathiresan, Sekar and Orho-Melander, Marju and Gudnason, Vilmundur and O'Donnell, Christopher J and Post, Wendy S and Thanassoulis, George}},
  issn         = {{1538-3598}},
  language     = {{eng}},
  number       = {{17}},
  pages        = {{1764--1771}},
  publisher    = {{American Medical Association}},
  series       = {{JAMA: The Journal of the American Medical Association}},
  title        = {{Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.}},
  url          = {{http://dx.doi.org/10.1001/jama.2014.13959}},
  doi          = {{10.1001/jama.2014.13959}},
  volume       = {{312}},
  year         = {{2014}},
}