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Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients.

Blimark, Cecilie; Holmberg, Erik; Mellqvist, Ulf-Henrik; Landgren, Ola; Björkholm, Magnus; Hultkrantz, Malin L; Kjellander, Christian; Turesson, Ingemar LU and Kristinsson, Sigurdur Y (2015) In Haematologica 100(1). p.107-113
Abstract
Infections are a major cause of morbidity and mortality in patients with multiple myeloma. To estimate the risk of bacterial and viral infections in multiple myeloma patients, we used population-based data from Sweden to identify all multiple myeloma patients (n=9 253) diagnosed from 1988 to 2004 with follow-up to 2007 and 34 931 matched controls. Cox proportional hazard models were used to estimate the risk of infections. Overall, multiple myeloma patients had a 7-fold (hazard ratio =7.1; 95% confidence interval = 6.8-7.4) risk of developing any infection compared to matched controls. The increased risk of developing a bacterial infection was 7-fold (7.1; 6.8-7.4), and for viral infections 10-fold (10.0; 8.9-11.4). Multiple myeloma... (More)
Infections are a major cause of morbidity and mortality in patients with multiple myeloma. To estimate the risk of bacterial and viral infections in multiple myeloma patients, we used population-based data from Sweden to identify all multiple myeloma patients (n=9 253) diagnosed from 1988 to 2004 with follow-up to 2007 and 34 931 matched controls. Cox proportional hazard models were used to estimate the risk of infections. Overall, multiple myeloma patients had a 7-fold (hazard ratio =7.1; 95% confidence interval = 6.8-7.4) risk of developing any infection compared to matched controls. The increased risk of developing a bacterial infection was 7-fold (7.1; 6.8-7.4), and for viral infections 10-fold (10.0; 8.9-11.4). Multiple myeloma patients diagnosed in the more recent calendar periods had significantly higher risk of infections compared to controls (p<0.001). At one year of follow-up, infection was the underlying cause in 22% of deaths in multiple myeloma patients. Mortality due to infections remained constant during the study period. Our findings confirm that infections represent a major threat to multiple myeloma patients. The effect on infectious complications due to novel drugs introduced in the treatment of multiple myeloma needs to be established and trials on prophylactic measures are needed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Haematologica
volume
100
issue
1
pages
107 - 113
publisher
Ferrata Storti Foundation
external identifiers
  • pmid:25344526
  • wos:000351278500030
  • scopus:84920175072
ISSN
1592-8721
DOI
10.3324/haematol.2014.107714
language
English
LU publication?
yes
id
f885b300-ec03-4e9e-80e7-ae8720c2f355 (old id 4733270)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25344526?dopt=Abstract
date added to LUP
2014-11-10 18:51:54
date last changed
2017-10-22 03:24:09
@article{f885b300-ec03-4e9e-80e7-ae8720c2f355,
  abstract     = {Infections are a major cause of morbidity and mortality in patients with multiple myeloma. To estimate the risk of bacterial and viral infections in multiple myeloma patients, we used population-based data from Sweden to identify all multiple myeloma patients (n=9 253) diagnosed from 1988 to 2004 with follow-up to 2007 and 34 931 matched controls. Cox proportional hazard models were used to estimate the risk of infections. Overall, multiple myeloma patients had a 7-fold (hazard ratio =7.1; 95% confidence interval = 6.8-7.4) risk of developing any infection compared to matched controls. The increased risk of developing a bacterial infection was 7-fold (7.1; 6.8-7.4), and for viral infections 10-fold (10.0; 8.9-11.4). Multiple myeloma patients diagnosed in the more recent calendar periods had significantly higher risk of infections compared to controls (p&lt;0.001). At one year of follow-up, infection was the underlying cause in 22% of deaths in multiple myeloma patients. Mortality due to infections remained constant during the study period. Our findings confirm that infections represent a major threat to multiple myeloma patients. The effect on infectious complications due to novel drugs introduced in the treatment of multiple myeloma needs to be established and trials on prophylactic measures are needed.},
  author       = {Blimark, Cecilie and Holmberg, Erik and Mellqvist, Ulf-Henrik and Landgren, Ola and Björkholm, Magnus and Hultkrantz, Malin L and Kjellander, Christian and Turesson, Ingemar and Kristinsson, Sigurdur Y},
  issn         = {1592-8721},
  language     = {eng},
  number       = {1},
  pages        = {107--113},
  publisher    = {Ferrata Storti Foundation},
  series       = {Haematologica},
  title        = {Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients.},
  url          = {http://dx.doi.org/10.3324/haematol.2014.107714},
  volume       = {100},
  year         = {2015},
}