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CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

Skillbäck, Tobias; Farahmand, Bahman; Bartlett, Jonathan W; Rosén, Christoffer; Mattsson, Niklas; Nägga, Katarina LU ; Kilander, Lena; Religa, Dorota; Wimo, Anders and Winblad, Bengt, et al. (2014) In Neurology 83(21). p.1945-1953
Abstract
We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.
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type
Contribution to journal
publication status
published
subject
in
Neurology
volume
83
issue
21
pages
1945 - 1953
publisher
American Academy of Neurology
external identifiers
  • pmid:25339208
  • wos:000345301000012
  • scopus:84922481519
ISSN
1526-632X
DOI
10.1212/WNL.0000000000001015
language
English
LU publication?
yes
id
d21cbefc-ed61-4ca2-b371-a389a4871afe (old id 4733359)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25339208?dopt=Abstract
date added to LUP
2014-11-10 17:47:02
date last changed
2017-11-19 03:16:44
@article{d21cbefc-ed61-4ca2-b371-a389a4871afe,
  abstract     = {We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.},
  author       = {Skillbäck, Tobias and Farahmand, Bahman and Bartlett, Jonathan W and Rosén, Christoffer and Mattsson, Niklas and Nägga, Katarina and Kilander, Lena and Religa, Dorota and Wimo, Anders and Winblad, Bengt and Rosengren, Lars and Schott, Jonathan M and Blennow, Kaj and Eriksdotter, Maria and Zetterberg, Henrik},
  issn         = {1526-632X},
  language     = {eng},
  number       = {21},
  pages        = {1945--1953},
  publisher    = {American Academy of Neurology},
  series       = {Neurology},
  title        = {CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.},
  url          = {http://dx.doi.org/10.1212/WNL.0000000000001015},
  volume       = {83},
  year         = {2014},
}