Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Distal radius fractures and risk of incident neurocognitive disorders in older adults : a retrospective cohort study

Baruth, Joshua M. ; Lapid, Maria I. ; Clarke, Bart ; Shin, Alexander Y. ; Atkinson, Elizabeth J. ; Eberhard, Jonas LU ; Zavatta, Guido and Åstrand, Jörgen LU (2022) In Osteoporosis International 33(11). p.2307-2314
Abstract

Introduction: Distal radius fractures (DRF) are associated with increased risk of subsequent fractures and physical decline in older adults. This study aims to evaluate the risk cognitive decline following DRF and potential for timely screening and intervention. Methods: A cohort of 1046 individuals 50–75 years of age with DRF were identified between 1995 and 2015 (81.5% female; mean age 62.5 [± 7.1] years). A control group (N = 1044) without history of DRF was matched by age, sex, and fracture date (i.e., index). The incidence of neurocognitive disorders (NCD) in relation to DRF/index was determined. Group comparisons were adjusted by age and comorbidity measured by the Elixhauser index. Results: The DRF group had a greater incidence... (More)

Introduction: Distal radius fractures (DRF) are associated with increased risk of subsequent fractures and physical decline in older adults. This study aims to evaluate the risk cognitive decline following DRF and potential for timely screening and intervention. Methods: A cohort of 1046 individuals 50–75 years of age with DRF were identified between 1995 and 2015 (81.5% female; mean age 62.5 [± 7.1] years). A control group (N = 1044) without history of DRF was matched by age, sex, and fracture date (i.e., index). The incidence of neurocognitive disorders (NCD) in relation to DRF/index was determined. Group comparisons were adjusted by age and comorbidity measured by the Elixhauser index. Results: The DRF group had a greater incidence of NCD compared to the control group (11.3% vs. 8.2%) with a 56% greater relative risk (HR = 1.56, 95% Cl: 1.18, 2.07; p = 0.002) after adjusting for age and comorbidity. For every 10-year age increase, the DRF group was over three times more likely to develop a NCD (HR = 3.23, 95% Cl: 2.57, 4.04; p < 0.001). Conclusion: DRF in adults ages 50 to 75 are associated with increased risk of developing neurocognitive disorders. DRF may represent a sentinel opportunity for cognitive screening and early intervention. Summary: Distal radius fractures (DRF) have been associated with greater risk of future fractures and physical decline. This study reports that DRF are also associated with greater risk of developing neurocognitive disorders in older adults. Timely intervention may improve early recognition and long-term outcomes for older adults at risk of cognitive decline.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, Debility, Dementia, Falls, Wrist fractures
in
Osteoporosis International
volume
33
issue
11
pages
2307 - 2314
publisher
Springer
external identifiers
  • scopus:85134301712
  • pmid:35835861
ISSN
0937-941X
DOI
10.1007/s00198-022-06497-6
language
English
LU publication?
yes
id
4735da85-579f-484b-b374-3fe45c77a1ee
date added to LUP
2022-10-03 16:38:47
date last changed
2024-06-13 14:01:54
@article{4735da85-579f-484b-b374-3fe45c77a1ee,
  abstract     = {{<p>Introduction: Distal radius fractures (DRF) are associated with increased risk of subsequent fractures and physical decline in older adults. This study aims to evaluate the risk cognitive decline following DRF and potential for timely screening and intervention. Methods: A cohort of 1046 individuals 50–75 years of age with DRF were identified between 1995 and 2015 (81.5% female; mean age 62.5 [± 7.1] years). A control group (N = 1044) without history of DRF was matched by age, sex, and fracture date (i.e., index). The incidence of neurocognitive disorders (NCD) in relation to DRF/index was determined. Group comparisons were adjusted by age and comorbidity measured by the Elixhauser index. Results: The DRF group had a greater incidence of NCD compared to the control group (11.3% vs. 8.2%) with a 56% greater relative risk (HR = 1.56, 95% Cl: 1.18, 2.07; p = 0.002) after adjusting for age and comorbidity. For every 10-year age increase, the DRF group was over three times more likely to develop a NCD (HR = 3.23, 95% Cl: 2.57, 4.04; p &lt; 0.001). Conclusion: DRF in adults ages 50 to 75 are associated with increased risk of developing neurocognitive disorders. DRF may represent a sentinel opportunity for cognitive screening and early intervention. Summary: Distal radius fractures (DRF) have been associated with greater risk of future fractures and physical decline. This study reports that DRF are also associated with greater risk of developing neurocognitive disorders in older adults. Timely intervention may improve early recognition and long-term outcomes for older adults at risk of cognitive decline.</p>}},
  author       = {{Baruth, Joshua M. and Lapid, Maria I. and Clarke, Bart and Shin, Alexander Y. and Atkinson, Elizabeth J. and Eberhard, Jonas and Zavatta, Guido and Åstrand, Jörgen}},
  issn         = {{0937-941X}},
  keywords     = {{Aging; Debility; Dementia; Falls; Wrist fractures}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{11}},
  pages        = {{2307--2314}},
  publisher    = {{Springer}},
  series       = {{Osteoporosis International}},
  title        = {{Distal radius fractures and risk of incident neurocognitive disorders in older adults : a retrospective cohort study}},
  url          = {{http://dx.doi.org/10.1007/s00198-022-06497-6}},
  doi          = {{10.1007/s00198-022-06497-6}},
  volume       = {{33}},
  year         = {{2022}},
}