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Self-powered wireless carbohydrate/oxygen sensitive biodevice based on radio signal transmission.

Falk, Magnus; Alcalde, Miguel; Bartlett, Philip N; De Lacey, Antonio L; Gorton, Lo; Gutierrez-Sanchez, Cristina; Haddad, Raoudha; Kilburn, Jeremy; Leech, Dónal and Ludwig, Roland, et al. (2014) In PLoS ONE 9(10).
Abstract
Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell generating sufficient current at required voltage to power the electronics. A carbohydrate/oxygen enzymatic fuel cell was assembled by comparing the performance of a range of different bioelectrodes followed by selection of the most suitable, stable combination. Carbohydrates (viz. lactose for the demonstration) and oxygen were also chosen as... (More)
Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell generating sufficient current at required voltage to power the electronics. A carbohydrate/oxygen enzymatic fuel cell was assembled by comparing the performance of a range of different bioelectrodes followed by selection of the most suitable, stable combination. Carbohydrates (viz. lactose for the demonstration) and oxygen were also chosen as bioanalytes, being important biomarkers, to demonstrate the operation of the self-contained biosensing device, employing enzyme-modified bioelectrodes to enable the actual sensing. A wireless electronic unit, consisting of a micropotentiostat, an energy harvesting module (voltage amplifier together with a capacitor), and a radio microchip, were designed to enable the biofuel cell to be used as a power supply for managing the sensing devices and for wireless data transmission. The electronic system used required current and voltages greater than 44 µA and 0.57 V, respectively to operate; which the biofuel cell was capable of providing, when placed in a carbohydrate and oxygen containing buffer. In addition, a USB based receiver and computer software were employed for proof-of concept tests of the developed biodevices. Operation of bench-top prototypes was demonstrated in buffers containing different concentrations of the analytes, showcasing that the variation in response of both carbohydrate and oxygen biosensors could be monitored wirelessly in real-time as analyte concentrations in buffers were changed, using only an enzymatic fuel cell as a power supply. (Less)
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PLoS ONE
volume
9
issue
10
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Public Library of Science
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  • pmid:25310190
  • wos:000343210300035
  • scopus:84907904030
ISSN
1932-6203
DOI
10.1371/journal.pone.0109104
language
English
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18f67bce-8a36-446a-8ddc-3a24c42c09af (old id 4737037)
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http://www.ncbi.nlm.nih.gov/pubmed/25310190?dopt=Abstract
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2014-11-07 17:29:16
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@article{18f67bce-8a36-446a-8ddc-3a24c42c09af,
  abstract     = {Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell generating sufficient current at required voltage to power the electronics. A carbohydrate/oxygen enzymatic fuel cell was assembled by comparing the performance of a range of different bioelectrodes followed by selection of the most suitable, stable combination. Carbohydrates (viz. lactose for the demonstration) and oxygen were also chosen as bioanalytes, being important biomarkers, to demonstrate the operation of the self-contained biosensing device, employing enzyme-modified bioelectrodes to enable the actual sensing. A wireless electronic unit, consisting of a micropotentiostat, an energy harvesting module (voltage amplifier together with a capacitor), and a radio microchip, were designed to enable the biofuel cell to be used as a power supply for managing the sensing devices and for wireless data transmission. The electronic system used required current and voltages greater than 44 µA and 0.57 V, respectively to operate; which the biofuel cell was capable of providing, when placed in a carbohydrate and oxygen containing buffer. In addition, a USB based receiver and computer software were employed for proof-of concept tests of the developed biodevices. Operation of bench-top prototypes was demonstrated in buffers containing different concentrations of the analytes, showcasing that the variation in response of both carbohydrate and oxygen biosensors could be monitored wirelessly in real-time as analyte concentrations in buffers were changed, using only an enzymatic fuel cell as a power supply.},
  articleno    = {e109104},
  author       = {Falk, Magnus and Alcalde, Miguel and Bartlett, Philip N and De Lacey, Antonio L and Gorton, Lo and Gutierrez-Sanchez, Cristina and Haddad, Raoudha and Kilburn, Jeremy and Leech, Dónal and Ludwig, Roland and Magner, Edmond and Mate, Diana M and Conghaile, Peter Ó and Ortiz, Roberto and Pita, Marcos and Pöller, Sascha and Ruzgas, Tautgirdas and Salaj-Kosla, Urszula and Schuhmann, Wolfgang and Sebelius, Fredrik and Shao, Minling and Stoica, Leonard and Sygmund, Cristoph and Tilly, Jonas and Toscano, Miguel D and Vivekananthan, Jeevanthi and Wright, Emma and Shleev, Sergey},
  issn         = {1932-6203},
  language     = {eng},
  number       = {10},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Self-powered wireless carbohydrate/oxygen sensitive biodevice based on radio signal transmission.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0109104},
  volume       = {9},
  year         = {2014},
}