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IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort.

Markkula, Andrea LU ; Simonsson, Maria LU ; Ingvar, Christian LU ; Rose, Carsten LU and Jernström, Helena LU (2014) In BMC Cancer 14.
Abstract
In breast cancer, high levels of the inflammatory cytokine interleukin-6 (IL-6) have been associated with disease-free survival and treatment resistance. Increased serum levels of IL-6 have been correlated with increased levels of NF-κβ and aromatase expression in adipose tissue. Several IL6 single nucleotide polymorphisms have been associated with breast cancer prognosis, but the impact may differ depending on tumour oestrogen receptor (ER) status. This translational study investigated the association between IL6 genotypes, ER-status, and treatment on the risk of early events among breast cancer patients.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Cancer
volume
14
publisher
BioMed Central
external identifiers
  • pmid:25305747
  • wos:000343259800001
  • scopus:84908067681
ISSN
1471-2407
DOI
10.1186/1471-2407-14-759
language
English
LU publication?
yes
id
0567c4d2-5982-4158-b21b-3faad52cc422 (old id 4737152)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25305747?dopt=Abstract
date added to LUP
2014-11-06 20:18:27
date last changed
2017-10-22 04:03:49
@article{0567c4d2-5982-4158-b21b-3faad52cc422,
  abstract     = {In breast cancer, high levels of the inflammatory cytokine interleukin-6 (IL-6) have been associated with disease-free survival and treatment resistance. Increased serum levels of IL-6 have been correlated with increased levels of NF-κβ and aromatase expression in adipose tissue. Several IL6 single nucleotide polymorphisms have been associated with breast cancer prognosis, but the impact may differ depending on tumour oestrogen receptor (ER) status. This translational study investigated the association between IL6 genotypes, ER-status, and treatment on the risk of early events among breast cancer patients.},
  articleno    = {759},
  author       = {Markkula, Andrea and Simonsson, Maria and Ingvar, Christian and Rose, Carsten and Jernström, Helena},
  issn         = {1471-2407},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Cancer},
  title        = {IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort.},
  url          = {http://dx.doi.org/10.1186/1471-2407-14-759},
  volume       = {14},
  year         = {2014},
}