IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort.
(2014) In BMC Cancer 14.- Abstract
- In breast cancer, high levels of the inflammatory cytokine interleukin-6 (IL-6) have been associated with disease-free survival and treatment resistance. Increased serum levels of IL-6 have been correlated with increased levels of NF-κβ and aromatase expression in adipose tissue. Several IL6 single nucleotide polymorphisms have been associated with breast cancer prognosis, but the impact may differ depending on tumour oestrogen receptor (ER) status. This translational study investigated the association between IL6 genotypes, ER-status, and treatment on the risk of early events among breast cancer patients.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4737152
- author
- Markkula, Andrea LU ; Simonsson, Maria LU ; Ingvar, Christian LU ; Rose, Carsten LU and Jernström, Helena LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Cancer
- volume
- 14
- article number
- 759
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:25305747
- wos:000343259800001
- scopus:84908067681
- pmid:25305747
- ISSN
- 1471-2407
- DOI
- 10.1186/1471-2407-14-759
- language
- English
- LU publication?
- yes
- id
- 0567c4d2-5982-4158-b21b-3faad52cc422 (old id 4737152)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25305747?dopt=Abstract
- date added to LUP
- 2016-04-01 13:14:34
- date last changed
- 2022-01-27 18:07:38
@article{0567c4d2-5982-4158-b21b-3faad52cc422, abstract = {{In breast cancer, high levels of the inflammatory cytokine interleukin-6 (IL-6) have been associated with disease-free survival and treatment resistance. Increased serum levels of IL-6 have been correlated with increased levels of NF-κβ and aromatase expression in adipose tissue. Several IL6 single nucleotide polymorphisms have been associated with breast cancer prognosis, but the impact may differ depending on tumour oestrogen receptor (ER) status. This translational study investigated the association between IL6 genotypes, ER-status, and treatment on the risk of early events among breast cancer patients.}}, author = {{Markkula, Andrea and Simonsson, Maria and Ingvar, Christian and Rose, Carsten and Jernström, Helena}}, issn = {{1471-2407}}, language = {{eng}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Cancer}}, title = {{IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort.}}, url = {{https://lup.lub.lu.se/search/files/3249588/5425581}}, doi = {{10.1186/1471-2407-14-759}}, volume = {{14}}, year = {{2014}}, }