Pre-existing immunity to adeno-associated virus (AAV)2 limits transgene expression following intracerebral AAV2-based gene delivery in a 6-hydroxydopamine model of Parkinson's disease.
(2014) In Journal of Gene Medicine 16(9-10). p.300-308- Abstract
- Adeno-associated virus (AAV) vectors are used to deliver potentially therapeutic genes in clinical trials in Parkinson's disease (PD). Pre-existing immunity to AAV and a local neuroinflammatory response might negatively affect the efficacy of such AAV-mediated gene delivery.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4737169
- author
- Janelidze, Shorena LU ; Nordström, Ulrika LU ; Kügler, Sebastian and Brundin, Patrik LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Gene Medicine
- volume
- 16
- issue
- 9-10
- pages
- 300 - 308
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:25303717
- wos:000344378400003
- scopus:84934274762
- pmid:25303717
- ISSN
- 1521-2254
- DOI
- 10.1002/jgm.2779
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Memory Research Unit (013242610), Neuronal Survival (013212041)
- id
- 8754fe83-98e7-4611-aefa-e5829df9eb4f (old id 4737169)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25303717?dopt=Abstract
- date added to LUP
- 2016-04-01 10:43:50
- date last changed
- 2022-04-04 20:44:35
@article{8754fe83-98e7-4611-aefa-e5829df9eb4f,
abstract = {{Adeno-associated virus (AAV) vectors are used to deliver potentially therapeutic genes in clinical trials in Parkinson's disease (PD). Pre-existing immunity to AAV and a local neuroinflammatory response might negatively affect the efficacy of such AAV-mediated gene delivery.}},
author = {{Janelidze, Shorena and Nordström, Ulrika and Kügler, Sebastian and Brundin, Patrik}},
issn = {{1521-2254}},
language = {{eng}},
number = {{9-10}},
pages = {{300--308}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Gene Medicine}},
title = {{Pre-existing immunity to adeno-associated virus (AAV)2 limits transgene expression following intracerebral AAV2-based gene delivery in a 6-hydroxydopamine model of Parkinson's disease.}},
url = {{https://lup.lub.lu.se/search/files/2086328/7525651}},
doi = {{10.1002/jgm.2779}},
volume = {{16}},
year = {{2014}},
}