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Pre-existing immunity to adeno-associated virus (AAV)2 limits transgene expression following intracerebral AAV2-based gene delivery in a 6-hydroxydopamine model of Parkinson's disease.

Janelidze, Shorena LU ; Nordström, Ulrika LU ; Kügler, Sebastian and Brundin, Patrik LU (2014) In Journal of Gene Medicine 16(9-10). p.300-308
Abstract
Adeno-associated virus (AAV) vectors are used to deliver potentially therapeutic genes in clinical trials in Parkinson's disease (PD). Pre-existing immunity to AAV and a local neuroinflammatory response might negatively affect the efficacy of such AAV-mediated gene delivery.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Gene Medicine
volume
16
issue
9-10
pages
300 - 308
publisher
John Wiley & Sons
external identifiers
  • pmid:25303717
  • wos:000344378400003
  • scopus:84934274762
ISSN
1521-2254
DOI
10.1002/jgm.2779
language
English
LU publication?
yes
id
8754fe83-98e7-4611-aefa-e5829df9eb4f (old id 4737169)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25303717?dopt=Abstract
date added to LUP
2014-11-07 17:02:49
date last changed
2017-05-21 03:17:59
@article{8754fe83-98e7-4611-aefa-e5829df9eb4f,
  abstract     = {Adeno-associated virus (AAV) vectors are used to deliver potentially therapeutic genes in clinical trials in Parkinson's disease (PD). Pre-existing immunity to AAV and a local neuroinflammatory response might negatively affect the efficacy of such AAV-mediated gene delivery.},
  author       = {Janelidze, Shorena and Nordström, Ulrika and Kügler, Sebastian and Brundin, Patrik},
  issn         = {1521-2254},
  language     = {eng},
  number       = {9-10},
  pages        = {300--308},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Gene Medicine},
  title        = {Pre-existing immunity to adeno-associated virus (AAV)2 limits transgene expression following intracerebral AAV2-based gene delivery in a 6-hydroxydopamine model of Parkinson's disease.},
  url          = {http://dx.doi.org/10.1002/jgm.2779},
  volume       = {16},
  year         = {2014},
}