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Mammography and Osteoporosis Screening-Clinical Risk Factors and Their Association With Digital X-Ray Radiogrammetry Bone Mineral Density.

Wilczek, Michael L; Nielsen, Christel LU ; Kälvesten, Johan; Algulin, Jakob and Brismar, Torkel B (2015) In Journal of Clinical Densitometry 18(1). p.22-29
Abstract
The aim of this study was to study the association between digital X-ray radiogrammetry (DXR) T-score and clinical risk factors for osteoporosis. Women were recruited 2 d per wk at a single mammography screening center between year 2010 and 2012. Included women answered a questionnaire about risk factors for osteoporosis, and a radiograph of the nondominant hand was obtained for DXR analysis. Univariate associations between DXR T-score and risk factors were examined. A generalized linear regression model was fitted to independent variables with univariate associations at p < 0.05. The multivariable model was reduced through manual backward elimination, with p > 0.1 as the exclusion criterion. Seventy-six percent of the women chose to... (More)
The aim of this study was to study the association between digital X-ray radiogrammetry (DXR) T-score and clinical risk factors for osteoporosis. Women were recruited 2 d per wk at a single mammography screening center between year 2010 and 2012. Included women answered a questionnaire about risk factors for osteoporosis, and a radiograph of the nondominant hand was obtained for DXR analysis. Univariate associations between DXR T-score and risk factors were examined. A generalized linear regression model was fitted to independent variables with univariate associations at p < 0.05. The multivariable model was reduced through manual backward elimination, with p > 0.1 as the exclusion criterion. Seventy-six percent of the women chose to participate in the study (n = 8810). The difference in number of daily mammograms performed on study vs nonstudy days was not significant. All univariate associations between DXR T-score and potential risk factors were highly significant. The multivariable model included height, weight, age, right-handedness, menopause before age 45, alcohol consumption, cortisone treatment, rheumatic disease, and age × smoking status. The coefficient of determination of the model was 0.37. The association between risk factors for osteoporosis and DXR T-score is similar to previously reported associations with dual-energy X-ray absorptiometry. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Densitometry
volume
18
issue
1
pages
22 - 29
publisher
Elsevier
external identifiers
  • pmid:25294740
  • wos:000348970300006
  • scopus:84921860848
ISSN
1094-6950
DOI
10.1016/j.jocd.2014.07.007
language
English
LU publication?
yes
id
a912e195-7607-4dd0-9fba-c752a79bec9f (old id 4737335)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25294740?dopt=Abstract
date added to LUP
2014-11-06 19:19:21
date last changed
2017-05-21 03:04:24
@article{a912e195-7607-4dd0-9fba-c752a79bec9f,
  abstract     = {The aim of this study was to study the association between digital X-ray radiogrammetry (DXR) T-score and clinical risk factors for osteoporosis. Women were recruited 2 d per wk at a single mammography screening center between year 2010 and 2012. Included women answered a questionnaire about risk factors for osteoporosis, and a radiograph of the nondominant hand was obtained for DXR analysis. Univariate associations between DXR T-score and risk factors were examined. A generalized linear regression model was fitted to independent variables with univariate associations at p &lt; 0.05. The multivariable model was reduced through manual backward elimination, with p &gt; 0.1 as the exclusion criterion. Seventy-six percent of the women chose to participate in the study (n = 8810). The difference in number of daily mammograms performed on study vs nonstudy days was not significant. All univariate associations between DXR T-score and potential risk factors were highly significant. The multivariable model included height, weight, age, right-handedness, menopause before age 45, alcohol consumption, cortisone treatment, rheumatic disease, and age × smoking status. The coefficient of determination of the model was 0.37. The association between risk factors for osteoporosis and DXR T-score is similar to previously reported associations with dual-energy X-ray absorptiometry.},
  author       = {Wilczek, Michael L and Nielsen, Christel and Kälvesten, Johan and Algulin, Jakob and Brismar, Torkel B},
  issn         = {1094-6950},
  language     = {eng},
  number       = {1},
  pages        = {22--29},
  publisher    = {Elsevier},
  series       = {Journal of Clinical Densitometry},
  title        = {Mammography and Osteoporosis Screening-Clinical Risk Factors and Their Association With Digital X-Ray Radiogrammetry Bone Mineral Density.},
  url          = {http://dx.doi.org/10.1016/j.jocd.2014.07.007},
  volume       = {18},
  year         = {2015},
}