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Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air.

Lyngen, Bjørn; Buhagen, Morten; Qvenild, Torgunn; Svendsen, Kristin; Tufvesson, Ellen LU and Hilt, Bjørn (2014) In Annals of Agricultural and Environmental Medicine 21(3). p.479-484
Abstract
Introduction and objective. Swine confinement buildings are known to contain large concentrations of airway irritants, and a number of studies have shown acute inflammatory effects in previously unexposed subjects when introduced to the environment in such buildings. However, studies comparing different methods of assessing such reactions are lacking, and it is not known if a measurable response could be found at lower exposure rates. The purpose of this study was to investigate exposure levels in a Norwegian swine confinement building, the airway response to such exposure, and to compare invasive and non-invasive methods of response measurement. Materials and method. Twelve medical students who were previously unexposed to swine dust... (More)
Introduction and objective. Swine confinement buildings are known to contain large concentrations of airway irritants, and a number of studies have shown acute inflammatory effects in previously unexposed subjects when introduced to the environment in such buildings. However, studies comparing different methods of assessing such reactions are lacking, and it is not known if a measurable response could be found at lower exposure rates. The purpose of this study was to investigate exposure levels in a Norwegian swine confinement building, the airway response to such exposure, and to compare invasive and non-invasive methods of response measurement. Materials and method. Twelve medical students who were previously unexposed to swine dust stayed in a swine confinement building in Norway for 4 hours, and underwent measurements before and after the start of exposure. The same measurements were also performed beforehand, on the same weekday without exposure, in such a manner that the subjects were their own controls. Results. The exposure assessment showed considerably lower concentrations of organic dust and endotoxin than earlier studies. However, small, but significant increases in markers of airway inflammation, were found. Conclusions. Airway response can be measured after lower exposure to airborne irritants in swine confinement buildings than previously known. Further research is needed to assess whether this finding can be utilized for preventive purposes. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Annals of Agricultural and Environmental Medicine
volume
21
issue
3
pages
479 - 484
publisher
Institute of Agricultural Medicine in Lublin, Poland
external identifiers
  • pmid:25292113
  • wos:000342188800006
  • scopus:84908011638
ISSN
1898-2263
DOI
10.5604/12321966.1120587
language
English
LU publication?
yes
id
4103a798-3d35-4a78-ac1d-673b087ef373 (old id 4737400)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25292113?dopt=Abstract
date added to LUP
2014-11-06 18:32:35
date last changed
2017-09-10 03:24:02
@article{4103a798-3d35-4a78-ac1d-673b087ef373,
  abstract     = {Introduction and objective. Swine confinement buildings are known to contain large concentrations of airway irritants, and a number of studies have shown acute inflammatory effects in previously unexposed subjects when introduced to the environment in such buildings. However, studies comparing different methods of assessing such reactions are lacking, and it is not known if a measurable response could be found at lower exposure rates. The purpose of this study was to investigate exposure levels in a Norwegian swine confinement building, the airway response to such exposure, and to compare invasive and non-invasive methods of response measurement. Materials and method. Twelve medical students who were previously unexposed to swine dust stayed in a swine confinement building in Norway for 4 hours, and underwent measurements before and after the start of exposure. The same measurements were also performed beforehand, on the same weekday without exposure, in such a manner that the subjects were their own controls. Results. The exposure assessment showed considerably lower concentrations of organic dust and endotoxin than earlier studies. However, small, but significant increases in markers of airway inflammation, were found. Conclusions. Airway response can be measured after lower exposure to airborne irritants in swine confinement buildings than previously known. Further research is needed to assess whether this finding can be utilized for preventive purposes.},
  author       = {Lyngen, Bjørn and Buhagen, Morten and Qvenild, Torgunn and Svendsen, Kristin and Tufvesson, Ellen and Hilt, Bjørn},
  issn         = {1898-2263},
  language     = {eng},
  number       = {3},
  pages        = {479--484},
  publisher    = {Institute of Agricultural Medicine in Lublin, Poland},
  series       = {Annals of Agricultural and Environmental Medicine},
  title        = {Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air.},
  url          = {http://dx.doi.org/10.5604/12321966.1120587},
  volume       = {21},
  year         = {2014},
}