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Prevention and early detection of prostate cancer.

Cuzick, Jack; Thorat, Mangesh A; Andriole, Gerald; Brawley, Otis W; Brown, Powel H; Culig, Zoran; Eeles, Rosalind A; Ford, Leslie G; Hamdy, Freddie C and Holmberg, Lars, et al. (2014) In The Lancet Oncology 15(11). p.484-492
Abstract
Prostate cancer is a common malignancy in men and the worldwide burden of this disease is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control offer opportunities to reduce the risk of developing prostate cancer. Early detection of prostate cancer by prostate-specific antigen (PSA) screening is controversial, but changes in the PSA threshold, frequency of screening, and the use of other biomarkers have the potential to minimise the overdiagnosis associated with PSA screening. Several new biomarkers for individuals with raised PSA concentrations or those diagnosed with prostate cancer are likely to identify individuals who can be spared aggressive treatment. Several pharmacological agents such as... (More)
Prostate cancer is a common malignancy in men and the worldwide burden of this disease is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control offer opportunities to reduce the risk of developing prostate cancer. Early detection of prostate cancer by prostate-specific antigen (PSA) screening is controversial, but changes in the PSA threshold, frequency of screening, and the use of other biomarkers have the potential to minimise the overdiagnosis associated with PSA screening. Several new biomarkers for individuals with raised PSA concentrations or those diagnosed with prostate cancer are likely to identify individuals who can be spared aggressive treatment. Several pharmacological agents such as 5α-reductase inhibitors and aspirin could prevent development of prostate cancer. In this Review, we discuss the present evidence and research questions regarding prevention, early detection of prostate cancer, and management of men either at high risk of prostate cancer or diagnosed with low-grade prostate cancer. (Less)
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Contribution to journal
publication status
published
subject
in
The Lancet Oncology
volume
15
issue
11
pages
484 - 492
publisher
Elsevier
external identifiers
  • pmid:25281467
  • wos:000343096800029
  • scopus:84908118271
ISSN
1474-5488
DOI
10.1016/S1470-2045(14)70211-6
language
English
LU publication?
yes
id
198f1d16-c819-4d34-acbc-78d0b664697c (old id 4738199)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25281467?dopt=Abstract
date added to LUP
2014-11-05 20:17:43
date last changed
2017-11-19 03:14:42
@article{198f1d16-c819-4d34-acbc-78d0b664697c,
  abstract     = {Prostate cancer is a common malignancy in men and the worldwide burden of this disease is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control offer opportunities to reduce the risk of developing prostate cancer. Early detection of prostate cancer by prostate-specific antigen (PSA) screening is controversial, but changes in the PSA threshold, frequency of screening, and the use of other biomarkers have the potential to minimise the overdiagnosis associated with PSA screening. Several new biomarkers for individuals with raised PSA concentrations or those diagnosed with prostate cancer are likely to identify individuals who can be spared aggressive treatment. Several pharmacological agents such as 5α-reductase inhibitors and aspirin could prevent development of prostate cancer. In this Review, we discuss the present evidence and research questions regarding prevention, early detection of prostate cancer, and management of men either at high risk of prostate cancer or diagnosed with low-grade prostate cancer.},
  author       = {Cuzick, Jack and Thorat, Mangesh A and Andriole, Gerald and Brawley, Otis W and Brown, Powel H and Culig, Zoran and Eeles, Rosalind A and Ford, Leslie G and Hamdy, Freddie C and Holmberg, Lars and Ilic, Dragan and Key, Timothy J and Vecchia, Carlo La and Lilja, Hans and Marberger, Michael and Meyskens, Frank L and Minasian, Lori M and Parker, Chris and Parnes, Howard L and Perner, Sven and Rittenhouse, Harry and Schalken, Jack and Schmid, Hans-Peter and Schmitz-Dräger, Bernd J and Schröder, Fritz H and Stenzl, Arnulf and Tombal, Bertrand and Wilt, Timothy J and Wolk, Alicja},
  issn         = {1474-5488},
  language     = {eng},
  number       = {11},
  pages        = {484--492},
  publisher    = {Elsevier},
  series       = {The Lancet Oncology},
  title        = {Prevention and early detection of prostate cancer.},
  url          = {http://dx.doi.org/10.1016/S1470-2045(14)70211-6},
  volume       = {15},
  year         = {2014},
}