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Complex selection associated with Hox genes in a natural population of lizards

Schwartz, Tonia; Perrin, Cecile; Wapstra, Erik; Uller, Tobias LU and Olsson, Mats (2011) In Journal of Evolutionary Biology 24(11). p.2550-2554
Abstract
Hox genes are recognized for their explanatory power of bilateral development. However, relatively little is known about natural variation in, and the evolutionary dynamics of, Hox genes within wild populations. Utilizing a natural population of sand lizards (Lacerta agilis), we screened HoxA13 for genetic variation and an association with incidence of offspring malformations. We found significant effects of parental genetic similarity and offspring sex, and their interaction, on risk of hatching malformed as an offspring. We also found within population genetic variation in HoxA13, and identified a significant effect of a three-way interaction among Hox genotype, parental genetic similarity, and offspring sex on the risk of hatching... (More)
Hox genes are recognized for their explanatory power of bilateral development. However, relatively little is known about natural variation in, and the evolutionary dynamics of, Hox genes within wild populations. Utilizing a natural population of sand lizards (Lacerta agilis), we screened HoxA13 for genetic variation and an association with incidence of offspring malformations. We found significant effects of parental genetic similarity and offspring sex, and their interaction, on risk of hatching malformed as an offspring. We also found within population genetic variation in HoxA13, and identified a significant effect of a three-way interaction among Hox genotype, parental genetic similarity, and offspring sex on the risk of hatching malformation. Since malformed offspring in this population do not survive to maturity, this study reveals complex and ongoing selection associated with Hox genes in a wild reptile population. Importantly, this demonstrates the utility of natural populations in unveiling microevolutionary processes shaping variation in highly conserved genes. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Evolutionary Biology
volume
24
issue
11
pages
2550 - 2554
publisher
John Wiley & Sons
external identifiers
  • scopus:80053978145
ISSN
1420-9101
DOI
10.1111/j.1420-9101.2011.02368.x
language
English
LU publication?
no
id
c74c596f-33b9-4077-93e1-e3bef6fcf331 (old id 4739017)
date added to LUP
2014-11-11 11:21:44
date last changed
2017-01-01 03:48:01
@article{c74c596f-33b9-4077-93e1-e3bef6fcf331,
  abstract     = {Hox genes are recognized for their explanatory power of bilateral development. However, relatively little is known about natural variation in, and the evolutionary dynamics of, Hox genes within wild populations. Utilizing a natural population of sand lizards (Lacerta agilis), we screened HoxA13 for genetic variation and an association with incidence of offspring malformations. We found significant effects of parental genetic similarity and offspring sex, and their interaction, on risk of hatching malformed as an offspring. We also found within population genetic variation in HoxA13, and identified a significant effect of a three-way interaction among Hox genotype, parental genetic similarity, and offspring sex on the risk of hatching malformation. Since malformed offspring in this population do not survive to maturity, this study reveals complex and ongoing selection associated with Hox genes in a wild reptile population. Importantly, this demonstrates the utility of natural populations in unveiling microevolutionary processes shaping variation in highly conserved genes.},
  author       = {Schwartz, Tonia and Perrin, Cecile and Wapstra, Erik and Uller, Tobias and Olsson, Mats},
  issn         = {1420-9101},
  language     = {eng},
  number       = {11},
  pages        = {2550--2554},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Evolutionary Biology},
  title        = {Complex selection associated with Hox genes in a natural population of lizards},
  url          = {http://dx.doi.org/10.1111/j.1420-9101.2011.02368.x},
  volume       = {24},
  year         = {2011},
}