An electrochemical-cantilever hybrid sensor for metal ions
(2010) IEEE Sensors p.913-917- Abstract
- In this work we have demonstrated a peptide functionalized cantilever sensor with integrated electrochemical capabilities. Silicon nitride cantilevers with gold electrodes are functionalized with the chelating peptide Cys-Gly-Gly-His (CGGH) to capture Cu2+ ions from solution. Upon binding the copper ion the peptide folds, creating steric hindrance and causing compressive stress in the monolayer, deflecting the cantilever downward. Ethylenediaminetetraacetic acid (EDTA) was used to remove the copper ions from the peptide, regenerating the layer. A Cysteine monolayer deflected the cantilever upward with Cu2+ ions, indicating tensile stress in the layer, suggesting a different coordination scheme than the CGGH peptide layer.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3164929
- author
- Fischer, Lee MacKenzie ; Dohn, S. ; Boisen, Anja and Tenje, Maria LU
- publishing date
- 2010
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- [Host publication title missing]
- pages
- 913 - 917
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- conference name
- IEEE Sensors
- conference location
- Waikoloa, United States
- conference dates
- 2010-11-01 - 2010-11-04
- external identifiers
-
- scopus:79951879739
- ISBN
- 978-1-4244-8170-5
- DOI
- 10.1109/ICSENS.2010.5690884
- language
- English
- LU publication?
- no
- id
- 474c4f4d-f77e-4d5e-93ac-5fcf97580f2c (old id 3164929)
- date added to LUP
- 2016-04-04 11:41:36
- date last changed
- 2022-01-29 22:14:58
@inproceedings{474c4f4d-f77e-4d5e-93ac-5fcf97580f2c, abstract = {{In this work we have demonstrated a peptide functionalized cantilever sensor with integrated electrochemical capabilities. Silicon nitride cantilevers with gold electrodes are functionalized with the chelating peptide Cys-Gly-Gly-His (CGGH) to capture Cu2+ ions from solution. Upon binding the copper ion the peptide folds, creating steric hindrance and causing compressive stress in the monolayer, deflecting the cantilever downward. Ethylenediaminetetraacetic acid (EDTA) was used to remove the copper ions from the peptide, regenerating the layer. A Cysteine monolayer deflected the cantilever upward with Cu2+ ions, indicating tensile stress in the layer, suggesting a different coordination scheme than the CGGH peptide layer.}}, author = {{Fischer, Lee MacKenzie and Dohn, S. and Boisen, Anja and Tenje, Maria}}, booktitle = {{[Host publication title missing]}}, isbn = {{978-1-4244-8170-5}}, language = {{eng}}, pages = {{913--917}}, publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}}, title = {{An electrochemical-cantilever hybrid sensor for metal ions}}, url = {{http://dx.doi.org/10.1109/ICSENS.2010.5690884}}, doi = {{10.1109/ICSENS.2010.5690884}}, year = {{2010}}, }