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Poor Reproducibility of Allergic Rhinitis SNP Associations

Nilsson, Daniel; Andiappan, Anand Kumar; Hallden, Christer; Tim, Chew Fook; Säll, Torbjörn LU ; Wang, De Yun and Cardell, Lars-Olaf (2013) In PLoS ONE 8(1).
Abstract
Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese population (948 AR-cases, 580 controls) were analyzed using 49 AR-associated SNPs. The overall pattern of P-values indicated that very few of the investigated SNPs were associated with AR. Given published odds ratios (ORs) most SNPs showed high power to detect an association, but no correlations were found between the ORs of the two study... (More)
Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese population (948 AR-cases, 580 controls) were analyzed using 49 AR-associated SNPs. The overall pattern of P-values indicated that very few of the investigated SNPs were associated with AR. Given published odds ratios (ORs) most SNPs showed high power to detect an association, but no correlations were found between the ORs of the two study populations or with published ORs. None of the association signals were in common to the two genome-wide association studies published in AR, indicating that the associations represent false positives or have much lower effect-sizes than reported. (Less)
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published
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in
PLoS ONE
volume
8
issue
1
publisher
Public Library of Science
external identifiers
  • wos:000315563800027
  • scopus:84873861750
ISSN
1932-6203
DOI
10.1371/journal.pone.0053975
language
English
LU publication?
yes
id
474cceba-97a4-43cd-9916-9f3e7f49c710 (old id 3657977)
date added to LUP
2013-04-24 12:43:57
date last changed
2019-01-06 08:23:05
@article{474cceba-97a4-43cd-9916-9f3e7f49c710,
  abstract     = {Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese population (948 AR-cases, 580 controls) were analyzed using 49 AR-associated SNPs. The overall pattern of P-values indicated that very few of the investigated SNPs were associated with AR. Given published odds ratios (ORs) most SNPs showed high power to detect an association, but no correlations were found between the ORs of the two study populations or with published ORs. None of the association signals were in common to the two genome-wide association studies published in AR, indicating that the associations represent false positives or have much lower effect-sizes than reported.},
  articleno    = {e53975},
  author       = {Nilsson, Daniel and Andiappan, Anand Kumar and Hallden, Christer and Tim, Chew Fook and Säll, Torbjörn and Wang, De Yun and Cardell, Lars-Olaf},
  issn         = {1932-6203},
  language     = {eng},
  number       = {1},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Poor Reproducibility of Allergic Rhinitis SNP Associations},
  url          = {http://dx.doi.org/10.1371/journal.pone.0053975},
  volume       = {8},
  year         = {2013},
}