Prognostic value of 18F-FET PET imaging in re-irradiation of high-grade glioma : Results of a phase I clinical trial
Moller, Soren ; Law, Ian ; Munck af Rosenschold, Per LU
; Costa, Junia
; Poulsen, Hans Skovgaard
; Engelholm, Svend Aage
and Engelholm, Silke
(2016)
In Radiotherapy and Oncology
121(1).
p.132-137
- Abstract
Background and purpose Positron emission tomography (PET) provides quantitative metabolic information and potential biomarkers of treatment outcome. We aimed to determine the prognostic value of early 18F-fluoroethyl-tyrosine (18F-FET) PET scans acquired during re-irradiation for recurrent high-grade glioma (HGG). Material and methods A phase I clinical trial of re-irradiation of HGG was carried out. MRI and 18F-FET PET were used for target delineation and follow-up. Images were acquired at baseline, during radiotherapy and 4 weeks post-treatment and compared by measuring the metabolically active biological tumor volume (BTV) and maximal activity (Tmax/B). Correlations with outcomes were... (More)
Background and purpose Positron emission tomography (PET) provides quantitative metabolic information and potential biomarkers of treatment outcome. We aimed to determine the prognostic value of early 18F-fluoroethyl-tyrosine (18F-FET) PET scans acquired during re-irradiation for recurrent high-grade glioma (HGG). Material and methods A phase I clinical trial of re-irradiation of HGG was carried out. MRI and 18F-FET PET were used for target delineation and follow-up. Images were acquired at baseline, during radiotherapy and 4 weeks post-treatment and compared by measuring the metabolically active biological tumor volume (BTV) and maximal activity (Tmax/B). Correlations with outcomes were assessed by multivariate Cox regression analysis. Results Thirty-one patients were included and all patients have died. The median overall survival was 7.0 mos. Both baseline BTV and baseline MRI volume (necrotic/cystic cavities subtracted) were prognostic for overall survival (OS) in multivariate analysis (HR = 1.3 p < 0.01 and HR = 1.3 p < 0.01, respectively). Early changes in BTV and Tmax/B were observed but they carried no independent prognostic information. Conclusions Baseline biological tumor volume (BTV) defined by 18F-FET PET was prognostic for OS in multivariate analysis, as was MRI volume (necrotic/cystic cavities subtracted). Tumor volume may aid in identifying patients whose life expectancy is too short to warrant re-irradiation.
(Less)
- author
- Moller, Soren
; Law, Ian
; Munck af Rosenschold, Per
LU
; Costa, Junia
; Poulsen, Hans Skovgaard
; Engelholm, Svend Aage
and Engelholm, Silke
- publishing date
- 2016-10-01
- type
- Contribution to journal
- publication status
- published
- keywords
- High-grade glioma, Metabolic imaging, MRI, Positron emission tomography, Prognostic markers, Re-irradiation
- in
- Radiotherapy and Oncology
- volume
- 121
- issue
- 1
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:27622554
- scopus:84992612666
- ISSN
- 0167-8140
- DOI
- 10.1016/j.radonc.2016.08.014
- language
- English
- LU publication?
- no
- id
- 4750122f-e9ef-4e18-a919-bc943e04ef68
- date added to LUP
- 2020-07-28 09:02:57
- date last changed
- 2024-03-20 14:50:13
@article{4750122f-e9ef-4e18-a919-bc943e04ef68,
abstract = {{<p>Background and purpose Positron emission tomography (PET) provides quantitative metabolic information and potential biomarkers of treatment outcome. We aimed to determine the prognostic value of early <sup>18</sup>F-fluoroethyl-tyrosine (<sup>18</sup>F-FET) PET scans acquired during re-irradiation for recurrent high-grade glioma (HGG). Material and methods A phase I clinical trial of re-irradiation of HGG was carried out. MRI and <sup>18</sup>F-FET PET were used for target delineation and follow-up. Images were acquired at baseline, during radiotherapy and 4 weeks post-treatment and compared by measuring the metabolically active biological tumor volume (BTV) and maximal activity (T<sub>max</sub>/B). Correlations with outcomes were assessed by multivariate Cox regression analysis. Results Thirty-one patients were included and all patients have died. The median overall survival was 7.0 mos. Both baseline BTV and baseline MRI volume (necrotic/cystic cavities subtracted) were prognostic for overall survival (OS) in multivariate analysis (HR = 1.3 p < 0.01 and HR = 1.3 p < 0.01, respectively). Early changes in BTV and T<sub>max</sub>/B were observed but they carried no independent prognostic information. Conclusions Baseline biological tumor volume (BTV) defined by <sup>18</sup>F-FET PET was prognostic for OS in multivariate analysis, as was MRI volume (necrotic/cystic cavities subtracted). Tumor volume may aid in identifying patients whose life expectancy is too short to warrant re-irradiation.</p>}},
author = {{Moller, Soren and Law, Ian and Munck af Rosenschold, Per and Costa, Junia and Poulsen, Hans Skovgaard and Engelholm, Svend Aage and Engelholm, Silke}},
issn = {{0167-8140}},
keywords = {{High-grade glioma; Metabolic imaging; MRI; Positron emission tomography; Prognostic markers; Re-irradiation}},
language = {{eng}},
month = {{10}},
number = {{1}},
pages = {{132--137}},
publisher = {{Elsevier}},
series = {{Radiotherapy and Oncology}},
title = {{Prognostic value of <sup>18</sup>F-FET PET imaging in re-irradiation of high-grade glioma : Results of a phase I clinical trial}},
url = {{http://dx.doi.org/10.1016/j.radonc.2016.08.014}},
doi = {{10.1016/j.radonc.2016.08.014}},
volume = {{121}},
year = {{2016}},
}