Advanced

Higher prevalence of type 2 diabetes in men than in women is associated with differences in visceral fat mass

Nordström, Anna; Hadrévi, Jenny; Olsson, Tommy; Franks, Paul W. LU and Nordström, Peter (2016) In Journal of Clinical Endocrinology and Metabolism 101(10). p.3740-3746
Abstract

Context: We have previously found that visceral fat is a stronger predictor for cardiovascular risk factors than body mass index (BMI). Objective: This study sought to investigate the prevalence of diabetes in elderly men and women in relation to objectively assessed visceral fat volume. Design and Setting: The cohort consisted of a population-based sample of 705 men and 688 women, all age 70 y at the time of examination. Main Outcome Measures: Associations between body fat estimates, plasma glucose level, and diabetes prevalence were investigated using multivariable-adjusted statistical models. Results: The prevalence of type 2 diabetes was 14.6% in men and 9.1% in women (P <.001). Mean... (More)

Context: We have previously found that visceral fat is a stronger predictor for cardiovascular risk factors than body mass index (BMI). Objective: This study sought to investigate the prevalence of diabetes in elderly men and women in relation to objectively assessed visceral fat volume. Design and Setting: The cohort consisted of a population-based sample of 705 men and 688 women, all age 70 y at the time of examination. Main Outcome Measures: Associations between body fat estimates, plasma glucose level, and diabetes prevalence were investigated using multivariable-adjusted statistical models. Results: The prevalence of type 2 diabetes was 14.6% in men and 9.1% in women (P <.001). Mean BMIwasslightlyhigherinmenthaninwomen(27.3vs26.6kg/m2; P =.01),withagreaterdifference in mean visceral fat mass (1987 vs 1077 g; P <.001). After adjustment for physical activity and smoking, men had about/approximately twice the odds of having type 2 diabetes compared with women (odds ratio [OR], 1.95; 95% confidence interval [CI], 1.38-2.76). The inclusion of BMI in this model did not change the risk associated with male sex (OR, 1.93; 95% CI, 1.34-2.77). However, whenvisceralfatwasincludedasacovariate,malesexwasnotassociatedwithincreasedriskoftype 2 diabetes (OR, 0.77; 95% CI, 0.51-1.18). Conclusions: The higher prevalence of type 2 diabetes in older men than in older women was associated with larger amount of visceral fat in men. In contrast, differences in BMI was not associated with this difference.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
101
issue
10
pages
7 pages
publisher
The Endocrine Society
external identifiers
  • scopus:84991725958
  • wos:000390849800029
ISSN
0021-972X
DOI
10.1210/jc.2016-1915
language
English
LU publication?
yes
id
47530e0a-3437-4d4a-89a1-10c7144cdca7
date added to LUP
2016-11-16 12:45:00
date last changed
2017-09-18 11:30:29
@article{47530e0a-3437-4d4a-89a1-10c7144cdca7,
  abstract     = {<p>Context: We have previously found that visceral fat is a stronger predictor for cardiovascular risk factors than body mass index (BMI). Objective: This study sought to investigate the prevalence of diabetes in elderly men and women in relation to objectively assessed visceral fat volume. Design and Setting: The cohort consisted of a population-based sample of 705 men and 688 women, all age 70 y at the time of examination. Main Outcome Measures: Associations between body fat estimates, plasma glucose level, and diabetes prevalence were investigated using multivariable-adjusted statistical models. Results: The prevalence of type 2 diabetes was 14.6% in men and 9.1% in women (P &lt;.001). Mean BMIwasslightlyhigherinmenthaninwomen(27.3vs26.6kg/m<sup>2</sup>; P =.01),withagreaterdifference in mean visceral fat mass (1987 vs 1077 g; P &lt;.001). After adjustment for physical activity and smoking, men had about/approximately twice the odds of having type 2 diabetes compared with women (odds ratio [OR], 1.95; 95% confidence interval [CI], 1.38-2.76). The inclusion of BMI in this model did not change the risk associated with male sex (OR, 1.93; 95% CI, 1.34-2.77). However, whenvisceralfatwasincludedasacovariate,malesexwasnotassociatedwithincreasedriskoftype 2 diabetes (OR, 0.77; 95% CI, 0.51-1.18). Conclusions: The higher prevalence of type 2 diabetes in older men than in older women was associated with larger amount of visceral fat in men. In contrast, differences in BMI was not associated with this difference.</p>},
  author       = {Nordström, Anna and Hadrévi, Jenny and Olsson, Tommy and Franks, Paul W. and Nordström, Peter},
  issn         = {0021-972X},
  language     = {eng},
  month        = {10},
  number       = {10},
  pages        = {3740--3746},
  publisher    = {The Endocrine Society},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Higher prevalence of type 2 diabetes in men than in women is associated with differences in visceral fat mass},
  url          = {http://dx.doi.org/10.1210/jc.2016-1915},
  volume       = {101},
  year         = {2016},
}