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Higher prevalence of type 2 diabetes in men than in women is associated with differences in visceral fat mass

Nordström, Anna ; Hadrévi, Jenny ; Olsson, Tommy ; Franks, Paul W. LU and Nordström, Peter (2016) In Journal of Clinical Endocrinology and Metabolism 101(10). p.3740-3746
Abstract

Context: We have previously found that visceral fat is a stronger predictor for cardiovascular risk factors than body mass index (BMI). Objective: This study sought to investigate the prevalence of diabetes in elderly men and women in relation to objectively assessed visceral fat volume. Design and Setting: The cohort consisted of a population-based sample of 705 men and 688 women, all age 70 y at the time of examination. Main Outcome Measures: Associations between body fat estimates, plasma glucose level, and diabetes prevalence were investigated using multivariable-adjusted statistical models. Results: The prevalence of type 2 diabetes was 14.6% in men and 9.1% in women (P <.001). Mean... (More)

Context: We have previously found that visceral fat is a stronger predictor for cardiovascular risk factors than body mass index (BMI). Objective: This study sought to investigate the prevalence of diabetes in elderly men and women in relation to objectively assessed visceral fat volume. Design and Setting: The cohort consisted of a population-based sample of 705 men and 688 women, all age 70 y at the time of examination. Main Outcome Measures: Associations between body fat estimates, plasma glucose level, and diabetes prevalence were investigated using multivariable-adjusted statistical models. Results: The prevalence of type 2 diabetes was 14.6% in men and 9.1% in women (P <.001). Mean BMIwasslightlyhigherinmenthaninwomen(27.3vs26.6kg/m2; P =.01),withagreaterdifference in mean visceral fat mass (1987 vs 1077 g; P <.001). After adjustment for physical activity and smoking, men had about/approximately twice the odds of having type 2 diabetes compared with women (odds ratio [OR], 1.95; 95% confidence interval [CI], 1.38-2.76). The inclusion of BMI in this model did not change the risk associated with male sex (OR, 1.93; 95% CI, 1.34-2.77). However, whenvisceralfatwasincludedasacovariate,malesexwasnotassociatedwithincreasedriskoftype 2 diabetes (OR, 0.77; 95% CI, 0.51-1.18). Conclusions: The higher prevalence of type 2 diabetes in older men than in older women was associated with larger amount of visceral fat in men. In contrast, differences in BMI was not associated with this difference.

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type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
101
issue
10
pages
7 pages
publisher
Oxford University Press
external identifiers
  • scopus:84991725958
  • pmid:27490920
  • wos:000390849800029
ISSN
0021-972X
DOI
10.1210/jc.2016-1915
language
English
LU publication?
yes
id
47530e0a-3437-4d4a-89a1-10c7144cdca7
date added to LUP
2016-11-16 12:45:00
date last changed
2025-01-12 14:46:14
@article{47530e0a-3437-4d4a-89a1-10c7144cdca7,
  abstract     = {{<p>Context: We have previously found that visceral fat is a stronger predictor for cardiovascular risk factors than body mass index (BMI). Objective: This study sought to investigate the prevalence of diabetes in elderly men and women in relation to objectively assessed visceral fat volume. Design and Setting: The cohort consisted of a population-based sample of 705 men and 688 women, all age 70 y at the time of examination. Main Outcome Measures: Associations between body fat estimates, plasma glucose level, and diabetes prevalence were investigated using multivariable-adjusted statistical models. Results: The prevalence of type 2 diabetes was 14.6% in men and 9.1% in women (P &lt;.001). Mean BMIwasslightlyhigherinmenthaninwomen(27.3vs26.6kg/m<sup>2</sup>; P =.01),withagreaterdifference in mean visceral fat mass (1987 vs 1077 g; P &lt;.001). After adjustment for physical activity and smoking, men had about/approximately twice the odds of having type 2 diabetes compared with women (odds ratio [OR], 1.95; 95% confidence interval [CI], 1.38-2.76). The inclusion of BMI in this model did not change the risk associated with male sex (OR, 1.93; 95% CI, 1.34-2.77). However, whenvisceralfatwasincludedasacovariate,malesexwasnotassociatedwithincreasedriskoftype 2 diabetes (OR, 0.77; 95% CI, 0.51-1.18). Conclusions: The higher prevalence of type 2 diabetes in older men than in older women was associated with larger amount of visceral fat in men. In contrast, differences in BMI was not associated with this difference.</p>}},
  author       = {{Nordström, Anna and Hadrévi, Jenny and Olsson, Tommy and Franks, Paul W. and Nordström, Peter}},
  issn         = {{0021-972X}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  pages        = {{3740--3746}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Clinical Endocrinology and Metabolism}},
  title        = {{Higher prevalence of type 2 diabetes in men than in women is associated with differences in visceral fat mass}},
  url          = {{http://dx.doi.org/10.1210/jc.2016-1915}},
  doi          = {{10.1210/jc.2016-1915}},
  volume       = {{101}},
  year         = {{2016}},
}