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High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks

Lundgren, Pia LU ; Jacobson, Lena ; Hård, Anna Lena ; Al-Hawasi, Abbas ; Larsson, Eva ; Gränse, Lotta LU orcid ; Saric, Marie ; Sunnqvist, Birgitta ; Tornqvist, Kristina LU and Wallin, Agneta , et al. (2021) In BMJ Open Ophthalmology 6(1).
Abstract

Objective Prematurity is a major risk factor for retinopathy of prematurity (ROP). We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort. Methods and analysis Infants with completed ROP screening, born at <24 GA weeks, 2007-2018 in Sweden were included. Data of GA, birth weight (BW), sex, neonatal morbidities, maximal ROP stage, aggressive posterior ROP (APROP), ROP treatments, treatment modality and treatment centre were retrieved. Results In total, 399 infants, with a mean GA of 23.2 weeks (range 21.9-23.9) and a mean BW of 567 g (range 340-874), were included. ROP was detected in 365 (91.5%) infants, 173 (43.4%) were treated for ROP and 68 of 173... (More)

Objective Prematurity is a major risk factor for retinopathy of prematurity (ROP). We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort. Methods and analysis Infants with completed ROP screening, born at <24 GA weeks, 2007-2018 in Sweden were included. Data of GA, birth weight (BW), sex, neonatal morbidities, maximal ROP stage, aggressive posterior ROP (APROP), ROP treatments, treatment modality and treatment centre were retrieved. Results In total, 399 infants, with a mean GA of 23.2 weeks (range 21.9-23.9) and a mean BW of 567 g (range 340-874), were included. ROP was detected in 365 (91.5%) infants, 173 (43.4%) were treated for ROP and 68 of 173 (39.3%) were treated more than once. As the first treatment, 142 (82.0%) received laser and 29 (16.1%) received intravitreal injection of antivascular endothelial growth factor (anti-VEGF). Retreatment was performed after first laser in 46 of 142 (32.4%) and in 20 of 29 (69.0%) after first anti-VEGF treatment. Retreatment rate was not associated with GA, BW or sex but with APROP, treatment method (anti-VEGF) and treatment centre where the laser was performed (p<0.001). Twenty eyes progressed to retinal detachment, and two infants developed unilateral endophthalmitis after anti-VEGF treatment. Conclusion Infants, born at <24 weeks' GA, had high rates of treatment-warranting ROP and retreatments. Treatment centre highly influenced the retreatment rate after laser indicating that laser treatment could be improved in some settings.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
retina
in
BMJ Open Ophthalmology
volume
6
issue
1
article number
e000695
publisher
BMJ Publishing Group
external identifiers
  • pmid:33981857
  • scopus:85104804718
ISSN
2397-3269
DOI
10.1136/bmjophth-2020-000695
language
English
LU publication?
yes
id
4755529c-aac9-4321-a12a-cfdfbb3c7d01
date added to LUP
2021-05-12 11:53:04
date last changed
2024-06-15 11:08:49
@article{4755529c-aac9-4321-a12a-cfdfbb3c7d01,
  abstract     = {{<p>Objective Prematurity is a major risk factor for retinopathy of prematurity (ROP). We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort. Methods and analysis Infants with completed ROP screening, born at &lt;24 GA weeks, 2007-2018 in Sweden were included. Data of GA, birth weight (BW), sex, neonatal morbidities, maximal ROP stage, aggressive posterior ROP (APROP), ROP treatments, treatment modality and treatment centre were retrieved. Results In total, 399 infants, with a mean GA of 23.2 weeks (range 21.9-23.9) and a mean BW of 567 g (range 340-874), were included. ROP was detected in 365 (91.5%) infants, 173 (43.4%) were treated for ROP and 68 of 173 (39.3%) were treated more than once. As the first treatment, 142 (82.0%) received laser and 29 (16.1%) received intravitreal injection of antivascular endothelial growth factor (anti-VEGF). Retreatment was performed after first laser in 46 of 142 (32.4%) and in 20 of 29 (69.0%) after first anti-VEGF treatment. Retreatment rate was not associated with GA, BW or sex but with APROP, treatment method (anti-VEGF) and treatment centre where the laser was performed (p&lt;0.001). Twenty eyes progressed to retinal detachment, and two infants developed unilateral endophthalmitis after anti-VEGF treatment. Conclusion Infants, born at &lt;24 weeks' GA, had high rates of treatment-warranting ROP and retreatments. Treatment centre highly influenced the retreatment rate after laser indicating that laser treatment could be improved in some settings.</p>}},
  author       = {{Lundgren, Pia and Jacobson, Lena and Hård, Anna Lena and Al-Hawasi, Abbas and Larsson, Eva and Gränse, Lotta and Saric, Marie and Sunnqvist, Birgitta and Tornqvist, Kristina and Wallin, Agneta and Holmstrom, Gerd E. and Smith, Lois L.E. and Morsing, Eva and Hellström, Ann}},
  issn         = {{2397-3269}},
  keywords     = {{retina}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{1}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open Ophthalmology}},
  title        = {{High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks}},
  url          = {{http://dx.doi.org/10.1136/bmjophth-2020-000695}},
  doi          = {{10.1136/bmjophth-2020-000695}},
  volume       = {{6}},
  year         = {{2021}},
}