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Corroboration of computational models for mechanoregulated stem cell differentiation

Khayyeri, Hanifeh LU ; Isaksson, Hanna LU and Prendergast, Patrick J (2015) In Computer Methods in Biomechanics and Biomedical Engineering 18(1). p.15-23
Abstract
Do computational models contribute to progress in mechanobiology? Jacobs and Kelly (in Advances on Modelling in Tissue Engineering, p. 1–14, 2011) suggest that they do, but at the same time propose a limitation in the form of the ‘paradox of validation’, whereby the information needed to validate mechanoregulation theories obviates the need for them in the first place. In this article, the corroboration of theories describing mechanoregulation of tissue differentiation is reviewed. Considering the falsifiability of computational models derived using the theories as a measure of their predictive power, it is shown that the predictive power of some theories is poor and that models based on these theories fall into the ‘paradox of... (More)
Do computational models contribute to progress in mechanobiology? Jacobs and Kelly (in Advances on Modelling in Tissue Engineering, p. 1–14, 2011) suggest that they do, but at the same time propose a limitation in the form of the ‘paradox of validation’, whereby the information needed to validate mechanoregulation theories obviates the need for them in the first place. In this article, the corroboration of theories describing mechanoregulation of tissue differentiation is reviewed. Considering the falsifiability of computational models derived using the theories as a measure of their predictive power, it is shown that the predictive power of some theories is poor and that models based on these theories fall into the ‘paradox of validation’. Week theories for any phenomenon would succumb to such a paradox. We argue that mechanobiology needs theories that can have more potentially falsifying experiments and that perhaps the discipline does suffer from theories that are a priori designed to minimise falsifiability. However, several theories do have predictive power beyond the data used to validate them, so a paradox of validation should disappear as the subject develops. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
mechanobiology, corroboration, computer model, K.R. Popper
in
Computer Methods in Biomechanics and Biomedical Engineering
volume
18
issue
1
pages
15 - 23
publisher
Taylor & Francis
external identifiers
  • wos:000343244000002
  • scopus:84908063220
ISSN
1025-5842
DOI
10.1080/10255842.2013.774381
language
English
LU publication?
yes
id
602c55bc-fcec-4de3-9f69-14208782834e (old id 4778797)
date added to LUP
2014-11-14 12:29:16
date last changed
2017-05-21 03:07:26
@article{602c55bc-fcec-4de3-9f69-14208782834e,
  abstract     = {Do computational models contribute to progress in mechanobiology? Jacobs and Kelly (in Advances on Modelling in Tissue Engineering, p. 1–14, 2011) suggest that they do, but at the same time propose a limitation in the form of the ‘paradox of validation’, whereby the information needed to validate mechanoregulation theories obviates the need for them in the first place. In this article, the corroboration of theories describing mechanoregulation of tissue differentiation is reviewed. Considering the falsifiability of computational models derived using the theories as a measure of their predictive power, it is shown that the predictive power of some theories is poor and that models based on these theories fall into the ‘paradox of validation’. Week theories for any phenomenon would succumb to such a paradox. We argue that mechanobiology needs theories that can have more potentially falsifying experiments and that perhaps the discipline does suffer from theories that are a priori designed to minimise falsifiability. However, several theories do have predictive power beyond the data used to validate them, so a paradox of validation should disappear as the subject develops.},
  author       = {Khayyeri, Hanifeh and Isaksson, Hanna and Prendergast, Patrick J},
  issn         = {1025-5842},
  keyword      = {mechanobiology,corroboration,computer model,K.R. Popper},
  language     = {eng},
  number       = {1},
  pages        = {15--23},
  publisher    = {Taylor & Francis},
  series       = {Computer Methods in Biomechanics and Biomedical Engineering},
  title        = {Corroboration of computational models for mechanoregulated stem cell differentiation},
  url          = {http://dx.doi.org/10.1080/10255842.2013.774381},
  volume       = {18},
  year         = {2015},
}