A Subtle Sister Mary Joseph Nodule in Metastatic Pancreatic Cancer
Abdulrasak, Mohammed LU
(2026)
In Diagnostics
16(8).
- Abstract
A 47-year-old woman with metastatic pancreatic adenocarcinoma, diagnosed five months earlier and treated with palliative chemotherapy, was admitted with fever, jaundice, and right upper quadrant pain consistent with ascending cholangitis. Treatment with antibiotics was initiated and an endoscopic retrograde cholangiography was performed, whereby a biliary stent was placed to relieve malignant biliary obstruction. Physical examination revealed moderate ascites. Careful inspection of the umbilicus revealed a small nodular lesion located within the umbilical fold that became visible only after eversion of the umbilicus. The lesion had developed gradually over several weeks. Computed tomography confirmed the known pancreatic malignancy with... (More)
A 47-year-old woman with metastatic pancreatic adenocarcinoma, diagnosed five months earlier and treated with palliative chemotherapy, was admitted with fever, jaundice, and right upper quadrant pain consistent with ascending cholangitis. Treatment with antibiotics was initiated and an endoscopic retrograde cholangiography was performed, whereby a biliary stent was placed to relieve malignant biliary obstruction. Physical examination revealed moderate ascites. Careful inspection of the umbilicus revealed a small nodular lesion located within the umbilical fold that became visible only after eversion of the umbilicus. The lesion had developed gradually over several weeks. Computed tomography confirmed the known pancreatic malignancy with metastatic disease and ascites. On re-review of the images, a small soft tissue nodule replacing the umbilicus was also visible. The lesion was clinically consistent with a Sister Mary Joseph nodule, an umbilical metastasis most commonly associated with advanced gastrointestinal or gynecologic malignancies. These lesions may arise through lymphatic or hematogenous spread or through direct extension into the umbilicus. This case highlights that umbilical metastases may be subtle and located within the umbilical fold, requiring careful physical examination to be detected.
(Less)
- author
- Abdulrasak, Mohammed
LU
- organization
- publishing date
- 2026-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- metastatic disease, physical examination, Sister Mary Joseph nodule
- in
- Diagnostics
- volume
- 16
- issue
- 8
- article number
- 1190
- publisher
- MDPI AG
- external identifiers
-
- pmid:42072814
- scopus:105037027287
- ISSN
- 2075-4418
- DOI
- 10.3390/diagnostics16081190
- language
- English
- LU publication?
- yes
- id
- 477d7937-e96b-44c2-a164-37c665e4da2e
- date added to LUP
- 2026-05-19 14:59:39
- date last changed
- 2026-05-20 03:05:50
@article{477d7937-e96b-44c2-a164-37c665e4da2e,
abstract = {{<p>A 47-year-old woman with metastatic pancreatic adenocarcinoma, diagnosed five months earlier and treated with palliative chemotherapy, was admitted with fever, jaundice, and right upper quadrant pain consistent with ascending cholangitis. Treatment with antibiotics was initiated and an endoscopic retrograde cholangiography was performed, whereby a biliary stent was placed to relieve malignant biliary obstruction. Physical examination revealed moderate ascites. Careful inspection of the umbilicus revealed a small nodular lesion located within the umbilical fold that became visible only after eversion of the umbilicus. The lesion had developed gradually over several weeks. Computed tomography confirmed the known pancreatic malignancy with metastatic disease and ascites. On re-review of the images, a small soft tissue nodule replacing the umbilicus was also visible. The lesion was clinically consistent with a Sister Mary Joseph nodule, an umbilical metastasis most commonly associated with advanced gastrointestinal or gynecologic malignancies. These lesions may arise through lymphatic or hematogenous spread or through direct extension into the umbilicus. This case highlights that umbilical metastases may be subtle and located within the umbilical fold, requiring careful physical examination to be detected.</p>}},
author = {{Abdulrasak, Mohammed}},
issn = {{2075-4418}},
keywords = {{metastatic disease; physical examination; Sister Mary Joseph nodule}},
language = {{eng}},
number = {{8}},
publisher = {{MDPI AG}},
series = {{Diagnostics}},
title = {{A Subtle Sister Mary Joseph Nodule in Metastatic Pancreatic Cancer}},
url = {{http://dx.doi.org/10.3390/diagnostics16081190}},
doi = {{10.3390/diagnostics16081190}},
volume = {{16}},
year = {{2026}},
}