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Vascular ageing in relation to chronological and self‑perceived age: A Swedish population‑based study

Johansson, Madeleine LU orcid and Nilsson, Peter M LU (2022) ARTERY 22 Conference In Artery Research 29. p.36-36
Abstract
Background: Chronological age is a key clinical determinant of
aortic stiffness. Self-perceived age (SPA) is a strong predictor of
well-being and long-term health. We aimed to investigate the
association between SPA, chronological age, and aortic stiffness
(vascular ageing) in the general population.

Methods: Cross-sectional analysis of a population-based study,
Malmö Offspring Study (n=3563). Mean age 42±14 years,
age range 18–74, 53.4% women. Participants completed aself-administered questionnaire related to SPA compared to same aged/sex peers graded: younger, no difference, older. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (c-f PWV; SphygmoCor), defined as > 10 m/s. Logistic... (More)
Background: Chronological age is a key clinical determinant of
aortic stiffness. Self-perceived age (SPA) is a strong predictor of
well-being and long-term health. We aimed to investigate the
association between SPA, chronological age, and aortic stiffness
(vascular ageing) in the general population.

Methods: Cross-sectional analysis of a population-based study,
Malmö Offspring Study (n=3563). Mean age 42±14 years,
age range 18–74, 53.4% women. Participants completed aself-administered questionnaire related to SPA compared to same aged/sex peers graded: younger, no difference, older. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (c-f PWV; SphygmoCor), defined as > 10 m/s. Logistic regression models were adjusted for chronological age and sex.

Results: Aortic stiffness occurred in 234 (6.6%) subjects. Mean age decreased gradually between all three SPA categories, with the highest mean age observed in subjects who perceived themselves as younger than same-aged/sex peers (49±1 vs. 40±1 vs. 32±1 years, p0.40, p=0.002). Adjustment for sex did not change this association (OR: 0.67, p=0.003). Upon adjustment for sex and chronological older SPA was associated with almost twofold increased likelihood of aortic stiffness (OR: 1.97, p=0.038). Sex-stratification demonstrated a stronger 2.5-fold likelihood of aortic stiffness in men (OR: 2.50, p=0.042), but no significant association in women (OR: 1.46,
p=0.43).

Conclusions: A negative self-perceived age (feeling older than same aged/sex peers) is associated with a 2.5-fold increased likelihood of aortic stiffness (vascular ageing) in men when adjusted for chronological age, but not in women. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aortic stiffness, Vascular ageing, population studies, ageing
in
Artery Research
volume
29
article number
P.104
pages
36 - 36
publisher
Elsevier
conference name
ARTERY 22 Conference
conference location
Nancy, France
conference dates
2022-10-19 - 2022-10-22
external identifiers
  • pmid:36776700
ISSN
1872-9312
DOI
10.1007/s44200-022-00028-8
project
Vascular Ageing and Arterial Stiffness in the Swedish Population
language
English
LU publication?
yes
id
477f10f7-2acf-47d8-94d2-1b30ec046b0b
date added to LUP
2023-02-21 02:31:30
date last changed
2024-06-15 15:32:50
@misc{477f10f7-2acf-47d8-94d2-1b30ec046b0b,
  abstract     = {{Background: Chronological age is a key clinical determinant of<br/>aortic stiffness. Self-perceived age (SPA) is a strong predictor of<br/>well-being and long-term health. We aimed to investigate the<br/>association between SPA, chronological age, and aortic stiffness<br/>(vascular ageing) in the general population.<br/><br/>Methods: Cross-sectional analysis of a population-based study,<br/>Malmö Offspring Study (n=3563). Mean age 42±14  years,<br/>age range 18–74, 53.4% women. Participants completed aself-administered questionnaire related to SPA compared to same aged/sex peers graded: younger, no difference, older. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (c-f PWV; SphygmoCor), defined as &gt; 10 m/s. Logistic regression models were adjusted for chronological age and sex.<br/><br/>Results: Aortic stiffness occurred in 234 (6.6%) subjects. Mean age decreased gradually between all three SPA categories, with the highest mean age observed in subjects who perceived themselves as younger than same-aged/sex peers (49±1 vs. 40±1 vs. 32±1 years, p0.40, p=0.002). Adjustment for sex did not change this association (OR: 0.67, p=0.003). Upon adjustment for sex and chronological older SPA was associated with almost twofold increased likelihood of aortic stiffness (OR: 1.97, p=0.038). Sex-stratification demonstrated a stronger 2.5-fold likelihood of aortic stiffness in men (OR: 2.50, p=0.042), but no significant association in women (OR: 1.46,<br/>p=0.43).<br/><br/>Conclusions: A negative self-perceived age (feeling older than same aged/sex peers) is associated with a 2.5-fold increased likelihood of aortic stiffness (vascular ageing) in men when adjusted for chronological age, but not in women.}},
  author       = {{Johansson, Madeleine and Nilsson, Peter M}},
  issn         = {{1872-9312}},
  keywords     = {{Aortic stiffness; Vascular ageing; population studies; ageing}},
  language     = {{eng}},
  note         = {{Conference Abstract}},
  pages        = {{36--36}},
  publisher    = {{Elsevier}},
  series       = {{Artery Research}},
  title        = {{Vascular ageing in relation to chronological and self‑perceived age: A Swedish population‑based study}},
  url          = {{http://dx.doi.org/10.1007/s44200-022-00028-8}},
  doi          = {{10.1007/s44200-022-00028-8}},
  volume       = {{29}},
  year         = {{2022}},
}