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Limited prognostic value of revised tumour deposit definition in tumour node metastasis (TNM) 8 in colorectal cancer : national cohort study

Stoltz, Frida ; Lundström, Simon LU orcid and Buchwald, Pamela LU (2026) In BJS Open 10(1). p.1-7
Abstract

BACKGROUND: Tumour deposits are an important prognostic factor in colorectal cancer. In tumour node metastasis (TNM)8, the definition became stricter as TNM7's previous requirement for absence of lymphatic tissue was expanded to also include nerve and vascular tissue. TNM8 has been criticised for its limited prognostic value. This study aimed to compare prognostic differences for patients with colorectal cancer with tumour deposits staged with TNM7 and TNM8.

METHODS: This national retrospective cohort study included patients with colorectal cancer who underwent surgical resection in 2011-2014 and 2017-2019. Exclusion criteria were metastatic stage IV disease, non-radical or non-curative surgery, unstated tumour deposit status, or... (More)

BACKGROUND: Tumour deposits are an important prognostic factor in colorectal cancer. In tumour node metastasis (TNM)8, the definition became stricter as TNM7's previous requirement for absence of lymphatic tissue was expanded to also include nerve and vascular tissue. TNM8 has been criticised for its limited prognostic value. This study aimed to compare prognostic differences for patients with colorectal cancer with tumour deposits staged with TNM7 and TNM8.

METHODS: This national retrospective cohort study included patients with colorectal cancer who underwent surgical resection in 2011-2014 and 2017-2019. Exclusion criteria were metastatic stage IV disease, non-radical or non-curative surgery, unstated tumour deposit status, or early (≤ 30 days) mortality. Univariable, multivariable, and interaction term Cox regression analyses examined differences in overall survival and distant metastasis between TNM7 and TNM8 stagings. Multivariable models were adjusted for age, gender, American Society of Anesthesiologists score, number of positive lymph nodes, TNM stage, neoadjuvant, and adjuvant treatment.

RESULTS: Of 19 413 patients operated on during 2011-2014 and 15 027 during 2017-2019, 23 966 were included. The TNM7 cohort had 1225 (9.5%) patients with tumour deposits, and the TNM8 cohort had 1407 (12.7%). There was an improved 5-year distant metastasis-free survival for patients with tumour deposits (hazard ratio 2.35 (95% confidence interval 2.14 to 2.58)) in the TNM8 cohort, but no benefit in overall survival, compared with patients in the TNM7 cohort. Interaction analysis revealed no prognostic difference associated with tumour deposit status between the two TNM editions.

CONCLUSION: Despite increased complexity, the revised definition of tumour deposits in TNM8 did not enhance prognostic ability compared with TNM7.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Male, Female, Prognosis, Retrospective Studies, Middle Aged, Colorectal Neoplasms/pathology, Neoplasm Staging/methods, Aged, Lymphatic Metastasis/pathology
in
BJS Open
volume
10
issue
1
article number
zraf148
pages
1 - 7
publisher
Wiley
external identifiers
  • scopus:105028200433
  • pmid:41564009
ISSN
2474-9842
DOI
10.1093/bjsopen/zraf148
language
English
LU publication?
yes
additional info
© The Author(s) 2026. Published by Oxford University Press on behalf of BJS Foundation Ltd.
id
478a4858-ee2d-4d80-97b0-840dc1aa5e2f
date added to LUP
2026-02-01 18:41:13
date last changed
2026-02-03 03:45:24
@article{478a4858-ee2d-4d80-97b0-840dc1aa5e2f,
  abstract     = {{<p>BACKGROUND: Tumour deposits are an important prognostic factor in colorectal cancer. In tumour node metastasis (TNM)8, the definition became stricter as TNM7's previous requirement for absence of lymphatic tissue was expanded to also include nerve and vascular tissue. TNM8 has been criticised for its limited prognostic value. This study aimed to compare prognostic differences for patients with colorectal cancer with tumour deposits staged with TNM7 and TNM8.</p><p>METHODS: This national retrospective cohort study included patients with colorectal cancer who underwent surgical resection in 2011-2014 and 2017-2019. Exclusion criteria were metastatic stage IV disease, non-radical or non-curative surgery, unstated tumour deposit status, or early (≤ 30 days) mortality. Univariable, multivariable, and interaction term Cox regression analyses examined differences in overall survival and distant metastasis between TNM7 and TNM8 stagings. Multivariable models were adjusted for age, gender, American Society of Anesthesiologists score, number of positive lymph nodes, TNM stage, neoadjuvant, and adjuvant treatment.</p><p>RESULTS: Of 19 413 patients operated on during 2011-2014 and 15 027 during 2017-2019, 23 966 were included. The TNM7 cohort had 1225 (9.5%) patients with tumour deposits, and the TNM8 cohort had 1407 (12.7%). There was an improved 5-year distant metastasis-free survival for patients with tumour deposits (hazard ratio 2.35 (95% confidence interval 2.14 to 2.58)) in the TNM8 cohort, but no benefit in overall survival, compared with patients in the TNM7 cohort. Interaction analysis revealed no prognostic difference associated with tumour deposit status between the two TNM editions.</p><p>CONCLUSION: Despite increased complexity, the revised definition of tumour deposits in TNM8 did not enhance prognostic ability compared with TNM7.</p>}},
  author       = {{Stoltz, Frida and Lundström, Simon and Buchwald, Pamela}},
  issn         = {{2474-9842}},
  keywords     = {{Humans; Male; Female; Prognosis; Retrospective Studies; Middle Aged; Colorectal Neoplasms/pathology; Neoplasm Staging/methods; Aged; Lymphatic Metastasis/pathology}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{1--7}},
  publisher    = {{Wiley}},
  series       = {{BJS Open}},
  title        = {{Limited prognostic value of revised tumour deposit definition in tumour node metastasis (TNM) 8 in colorectal cancer : national cohort study}},
  url          = {{http://dx.doi.org/10.1093/bjsopen/zraf148}},
  doi          = {{10.1093/bjsopen/zraf148}},
  volume       = {{10}},
  year         = {{2026}},
}