Is there a change in myocardial nonlinearity during the cardiac cycle?
(2001) In Ultrasound in Medicine and Biology 27(3). p.389-398- Abstract
The distortion of a sound wave during propagation results in progressive transfer of the energy from fundamental to higher harmonics, and is dependent on the nonlinearity of the medium. We studied if relative changes in acoustical nonlinearity occur in healthy myocardium during the cardiac cycle. Radiofrequency data were acquired from transthoracic echocardiography (2.5 and 3.5 MHz), parasternal long axis view, from five dogs and nine healthy volunteers. Integrated backscatter was calculated after filtering for fundamental (FIB) and second harmonic frequencies (SHIB), from a region in the posterior myocardial wall. The results suggest that there is little difference between the SHIB and FIB, although there were large variations between... (More)
The distortion of a sound wave during propagation results in progressive transfer of the energy from fundamental to higher harmonics, and is dependent on the nonlinearity of the medium. We studied if relative changes in acoustical nonlinearity occur in healthy myocardium during the cardiac cycle. Radiofrequency data were acquired from transthoracic echocardiography (2.5 and 3.5 MHz), parasternal long axis view, from five dogs and nine healthy volunteers. Integrated backscatter was calculated after filtering for fundamental (FIB) and second harmonic frequencies (SHIB), from a region in the posterior myocardial wall. The results suggest that there is little difference between the SHIB and FIB, although there were large variations between individuals. The maximal changes in nonlinearity, as estimated by SHIB/FIB ratio, mostly occurred during systole. SHIB presented similar cyclic variation with FIB (p = NS). Further studies are necessary to separate the role of myocardial nonlinearity, attenuation, propagating distance, or acoustical properties of the blood. The results are important in further tissue characterization studies employing second harmonic data.
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- author
- Pislaru, Cristina ; D'Hooge, Jan ; Pislaru, Sorin V. ; Brandt, Einar LU ; Cipic, Robert ; Angermann, Christiane E. ; Van De Werf, Frans J. ; Bijnens, Bart ; Herregods, Marie Cristiane and Sutherland, George R.
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- keywords
- Acoustics, B/A, Echocardiography, Integrated backscatter, Myocardial contraction, Nonlinearity parameter of the medium, Tissue characterization, Ultrasonics
- in
- Ultrasound in Medicine and Biology
- volume
- 27
- issue
- 3
- pages
- 389 - 398
- publisher
- Elsevier
- external identifiers
-
- pmid:11369125
- scopus:0035005030
- ISSN
- 0301-5629
- DOI
- 10.1016/S0301-5629(00)00336-7
- language
- English
- LU publication?
- no
- id
- 478e9d9b-a7c6-45cb-b841-f31205f83c07
- date added to LUP
- 2022-10-21 10:24:39
- date last changed
- 2025-01-11 17:57:03
@article{478e9d9b-a7c6-45cb-b841-f31205f83c07,
abstract = {{<p>The distortion of a sound wave during propagation results in progressive transfer of the energy from fundamental to higher harmonics, and is dependent on the nonlinearity of the medium. We studied if relative changes in acoustical nonlinearity occur in healthy myocardium during the cardiac cycle. Radiofrequency data were acquired from transthoracic echocardiography (2.5 and 3.5 MHz), parasternal long axis view, from five dogs and nine healthy volunteers. Integrated backscatter was calculated after filtering for fundamental (FIB) and second harmonic frequencies (SHIB), from a region in the posterior myocardial wall. The results suggest that there is little difference between the SHIB and FIB, although there were large variations between individuals. The maximal changes in nonlinearity, as estimated by SHIB/FIB ratio, mostly occurred during systole. SHIB presented similar cyclic variation with FIB (p = NS). Further studies are necessary to separate the role of myocardial nonlinearity, attenuation, propagating distance, or acoustical properties of the blood. The results are important in further tissue characterization studies employing second harmonic data.</p>}},
author = {{Pislaru, Cristina and D'Hooge, Jan and Pislaru, Sorin V. and Brandt, Einar and Cipic, Robert and Angermann, Christiane E. and Van De Werf, Frans J. and Bijnens, Bart and Herregods, Marie Cristiane and Sutherland, George R.}},
issn = {{0301-5629}},
keywords = {{Acoustics; B/A; Echocardiography; Integrated backscatter; Myocardial contraction; Nonlinearity parameter of the medium; Tissue characterization; Ultrasonics}},
language = {{eng}},
number = {{3}},
pages = {{389--398}},
publisher = {{Elsevier}},
series = {{Ultrasound in Medicine and Biology}},
title = {{Is there a change in myocardial nonlinearity during the cardiac cycle?}},
url = {{http://dx.doi.org/10.1016/S0301-5629(00)00336-7}},
doi = {{10.1016/S0301-5629(00)00336-7}},
volume = {{27}},
year = {{2001}},
}