Advanced

Plasma Melatonin Is Reduced in Huntington's Disease

Kalliolia, Eirini; Silajdzic, Edina LU ; Nambron, Rajasree; Hill, Nathan R.; Doshi, Anisha; Frost, Chris; Watt, Hilary; Hindmarsh, Peter; Björkqvist, Maria LU and Warner, Thomas T. (2014) In Movement Disorders 29(12). p.1511-1515
Abstract
This study was undertaken to determine whether the production of melatonin, a hormone regulating sleep in relation to the light/dark cycle, is altered in Huntington's disease. We analyzed the circadian rhythm of melatonin in a 24-hour study of cohorts of control, premanifest, and stage II/III Huntington's disease subjects. The mean and acrophase melatonin concentrations were significantly reduced in stage II/III Huntington's disease subjects compared with controls. We also observed a nonsignificant trend toward reduced mean and acrophase melatonin in premanifest Huntington's disease subjects. Onset of melatonin rise was significantly more temporally spread in both premanifest and stage II/III Huntington's disease subjects compared with... (More)
This study was undertaken to determine whether the production of melatonin, a hormone regulating sleep in relation to the light/dark cycle, is altered in Huntington's disease. We analyzed the circadian rhythm of melatonin in a 24-hour study of cohorts of control, premanifest, and stage II/III Huntington's disease subjects. The mean and acrophase melatonin concentrations were significantly reduced in stage II/III Huntington's disease subjects compared with controls. We also observed a nonsignificant trend toward reduced mean and acrophase melatonin in premanifest Huntington's disease subjects. Onset of melatonin rise was significantly more temporally spread in both premanifest and stage II/III Huntington's disease subjects compared with controls. A nonsignificant trend also was seen for reduced pulsatile secretion of melatonin. Melatonin concentrations are reduced in Huntington's disease. Altered melatonin patterns may provide an explanation for disrupted sleep and circadian behavior in Huntington's disease, and represent a biomarker for disease state. Melatonin therapy may help the sleep disorders seen in Huntington's disease. (c) 2014 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Huntington's disease, melatonin, circadian rhythm
in
Movement Disorders
volume
29
issue
12
pages
1511 - 1515
publisher
John Wiley & Sons
external identifiers
  • wos:000342793700008
  • scopus:84927523335
ISSN
0885-3185
DOI
10.1002/mds.26003
language
English
LU publication?
yes
id
660c3b17-3971-4293-9c22-7e13387f1c74 (old id 4796401)
date added to LUP
2014-12-01 07:33:22
date last changed
2017-09-03 03:08:42
@article{660c3b17-3971-4293-9c22-7e13387f1c74,
  abstract     = {This study was undertaken to determine whether the production of melatonin, a hormone regulating sleep in relation to the light/dark cycle, is altered in Huntington's disease. We analyzed the circadian rhythm of melatonin in a 24-hour study of cohorts of control, premanifest, and stage II/III Huntington's disease subjects. The mean and acrophase melatonin concentrations were significantly reduced in stage II/III Huntington's disease subjects compared with controls. We also observed a nonsignificant trend toward reduced mean and acrophase melatonin in premanifest Huntington's disease subjects. Onset of melatonin rise was significantly more temporally spread in both premanifest and stage II/III Huntington's disease subjects compared with controls. A nonsignificant trend also was seen for reduced pulsatile secretion of melatonin. Melatonin concentrations are reduced in Huntington's disease. Altered melatonin patterns may provide an explanation for disrupted sleep and circadian behavior in Huntington's disease, and represent a biomarker for disease state. Melatonin therapy may help the sleep disorders seen in Huntington's disease. (c) 2014 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.},
  author       = {Kalliolia, Eirini and Silajdzic, Edina and Nambron, Rajasree and Hill, Nathan R. and Doshi, Anisha and Frost, Chris and Watt, Hilary and Hindmarsh, Peter and Björkqvist, Maria and Warner, Thomas T.},
  issn         = {0885-3185},
  keyword      = {Huntington's disease,melatonin,circadian rhythm},
  language     = {eng},
  number       = {12},
  pages        = {1511--1515},
  publisher    = {John Wiley & Sons},
  series       = {Movement Disorders},
  title        = {Plasma Melatonin Is Reduced in Huntington's Disease},
  url          = {http://dx.doi.org/10.1002/mds.26003},
  volume       = {29},
  year         = {2014},
}