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Astrocytes impose postburst depression of release probability at hippocampal glutamate synapses

Andersson, My LU and Hanse, Eric (2010) In The Journal of neuroscience : the official journal of the Society for Neuroscience 30(16). p.80-5776
Abstract

Many neurons typically fire action potentials in brief, high-frequency bursts with specific consequences for their synaptic output. Here we have examined short-term plasticity engaged during burst activation using electrophysiological recordings in acute rat hippocampal slices. We show that CA3-CA1 glutamate synapses exhibit a prominent depression of presynaptic release probability for approximately 1 s after such a burst. This postburst depression exhibits a distinct cooperativity threshold, is abolished by inhibiting astrocyte metabolism and astrocyte calcium signaling, and is not operational in the developing hippocampus. Our results suggest that astrocytes are actively involved in short-term synaptic depression, shaping synaptic... (More)

Many neurons typically fire action potentials in brief, high-frequency bursts with specific consequences for their synaptic output. Here we have examined short-term plasticity engaged during burst activation using electrophysiological recordings in acute rat hippocampal slices. We show that CA3-CA1 glutamate synapses exhibit a prominent depression of presynaptic release probability for approximately 1 s after such a burst. This postburst depression exhibits a distinct cooperativity threshold, is abolished by inhibiting astrocyte metabolism and astrocyte calcium signaling, and is not operational in the developing hippocampus. Our results suggest that astrocytes are actively involved in short-term synaptic depression, shaping synaptic activity during behaviorally relevant neural activity.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Astrocytes, CA1 Region, Hippocampal, CA3 Region, Hippocampal, Glutamic Acid, Hippocampus, Long-Term Synaptic Depression, Neuronal Plasticity, Probability, Rats, Rats, Wistar, Receptors, Glutamate, Synapses, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
in
The Journal of neuroscience : the official journal of the Society for Neuroscience
volume
30
issue
16
pages
5 pages
publisher
Society for Neuroscience
external identifiers
  • scopus:77951549511
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.3957-09.2010
language
English
LU publication?
no
id
47a5539b-30b7-469e-85df-6d7f708fa398
date added to LUP
2017-03-30 17:02:46
date last changed
2018-05-29 10:54:58
@article{47a5539b-30b7-469e-85df-6d7f708fa398,
  abstract     = {<p>Many neurons typically fire action potentials in brief, high-frequency bursts with specific consequences for their synaptic output. Here we have examined short-term plasticity engaged during burst activation using electrophysiological recordings in acute rat hippocampal slices. We show that CA3-CA1 glutamate synapses exhibit a prominent depression of presynaptic release probability for approximately 1 s after such a burst. This postburst depression exhibits a distinct cooperativity threshold, is abolished by inhibiting astrocyte metabolism and astrocyte calcium signaling, and is not operational in the developing hippocampus. Our results suggest that astrocytes are actively involved in short-term synaptic depression, shaping synaptic activity during behaviorally relevant neural activity.</p>},
  author       = {Andersson, My and Hanse, Eric},
  issn         = {1529-2401},
  keyword      = {Animals,Astrocytes,CA1 Region, Hippocampal,CA3 Region, Hippocampal,Glutamic Acid,Hippocampus,Long-Term Synaptic Depression,Neuronal Plasticity,Probability,Rats,Rats, Wistar,Receptors, Glutamate,Synapses,Comparative Study,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {04},
  number       = {16},
  pages        = {80--5776},
  publisher    = {Society for Neuroscience},
  series       = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  title        = {Astrocytes impose postburst depression of release probability at hippocampal glutamate synapses},
  url          = {http://dx.doi.org/10.1523/JNEUROSCI.3957-09.2010},
  volume       = {30},
  year         = {2010},
}