Iohexol clearance for GFR-determination in renal failure - single or multiple plasma sampling?
(1996) In Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 11(3). p.521-525- Abstract
- The present study examined the agreement between single and multiple sample plasma clearance of iohexol, a non-ionic contrast agent, in renal failure. Sixty-five patients with varying degree of renal insufficiency received 10 ml iohexol (300 mg I/ml) i.v. and plasma samples were collected four times during the following 3-24 h. Plasma-iodine concentrations were determined by X-ray fluorescence. Predicted creatinine clearance was used to choose one of the samples for determination of single sample clearance. A single plasma specimen collected at 4 h for GFR above 50 ml/min, at 7 h for GFR between 20 and 50 ml/min, and at 24 h for GFR below 20 ml/min gave values in good agreement with those based on a four sample slope clearance. No sign of... (More)
- The present study examined the agreement between single and multiple sample plasma clearance of iohexol, a non-ionic contrast agent, in renal failure. Sixty-five patients with varying degree of renal insufficiency received 10 ml iohexol (300 mg I/ml) i.v. and plasma samples were collected four times during the following 3-24 h. Plasma-iodine concentrations were determined by X-ray fluorescence. Predicted creatinine clearance was used to choose one of the samples for determination of single sample clearance. A single plasma specimen collected at 4 h for GFR above 50 ml/min, at 7 h for GFR between 20 and 50 ml/min, and at 24 h for GFR below 20 ml/min gave values in good agreement with those based on a four sample slope clearance. No sign of nephrotoxicity was noted after administration of the contrast agent. It is concluded that single sample plasma clearance after single injection of iohexol gives a good estimate of GFR in renal failure and is advantageous in clinical practice. (Less)
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https://lup.lub.lu.se/record/47a83a06-9233-450c-b6c1-d4014beef1f2
- author
- Sterner, Gunnar LU ; Frennby, Bo LU ; Hultberg, Björn LU and Almén, Torsten LU
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- in
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
- volume
- 11
- issue
- 3
- pages
- 521 - 525
- publisher
- Oxford University Press
- external identifiers
-
- pmid:8671824
- scopus:0029974497
- ISSN
- 1460-2385
- DOI
- 10.1093/ndt/11.3.521
- language
- English
- LU publication?
- no
- id
- 47a83a06-9233-450c-b6c1-d4014beef1f2
- date added to LUP
- 2019-10-27 15:47:56
- date last changed
- 2022-02-01 01:34:00
@article{47a83a06-9233-450c-b6c1-d4014beef1f2,
abstract = {{The present study examined the agreement between single and multiple sample plasma clearance of iohexol, a non-ionic contrast agent, in renal failure. Sixty-five patients with varying degree of renal insufficiency received 10 ml iohexol (300 mg I/ml) i.v. and plasma samples were collected four times during the following 3-24 h. Plasma-iodine concentrations were determined by X-ray fluorescence. Predicted creatinine clearance was used to choose one of the samples for determination of single sample clearance. A single plasma specimen collected at 4 h for GFR above 50 ml/min, at 7 h for GFR between 20 and 50 ml/min, and at 24 h for GFR below 20 ml/min gave values in good agreement with those based on a four sample slope clearance. No sign of nephrotoxicity was noted after administration of the contrast agent. It is concluded that single sample plasma clearance after single injection of iohexol gives a good estimate of GFR in renal failure and is advantageous in clinical practice.}},
author = {{Sterner, Gunnar and Frennby, Bo and Hultberg, Björn and Almén, Torsten}},
issn = {{1460-2385}},
language = {{eng}},
number = {{3}},
pages = {{521--525}},
publisher = {{Oxford University Press}},
series = {{Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association}},
title = {{Iohexol clearance for GFR-determination in renal failure - single or multiple plasma sampling?}},
url = {{http://dx.doi.org/10.1093/ndt/11.3.521}},
doi = {{10.1093/ndt/11.3.521}},
volume = {{11}},
year = {{1996}},
}