Biochemical tissue-specific injury markers of the heart and brain in postpartum cord blood
(2009) In American Journal of Obstetrics and Gynecology 200(3). p.1-273- Abstract
- OBJECTIVE: We sought to establish references ranges and to test the hypothesis that biochemical tissue-specific markers for the heart in umbilical cord blood of newborns with cardiac defects and intrauterine growth restriction (IUGR) are abnormal. STUDY DESIGN: A prospective study was conducted. Serum samples of the umbilical vein (n = 280) and artery (n = 156) from 599 healthy newborns at 37(+0)-42(+0) weeks of gestation were collected. Total creatine kinase (CK), CK-MB heart type (CK-MB), cardiac troponin T (cTnT), myoglobin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and S100 were measured. Reference ranges for each marker were constructed. Concentrations of tissue-specific markers from umbilical cord blood of neonates with... (More)
- OBJECTIVE: We sought to establish references ranges and to test the hypothesis that biochemical tissue-specific markers for the heart in umbilical cord blood of newborns with cardiac defects and intrauterine growth restriction (IUGR) are abnormal. STUDY DESIGN: A prospective study was conducted. Serum samples of the umbilical vein (n = 280) and artery (n = 156) from 599 healthy newborns at 37(+0)-42(+0) weeks of gestation were collected. Total creatine kinase (CK), CK-MB heart type (CK-MB), cardiac troponin T (cTnT), myoglobin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and S100 were measured. Reference ranges for each marker were constructed. Concentrations of tissue-specific markers from umbilical cord blood of neonates with cardiac defects (n = 10) and IUGR (n = 41) were plotted against the established reference ranges. RESULTS: Reference ranges for each studied marker were established for both umbilical artery and vein. In fetuses with cardiac defects, both NT-proBNP (4/6 [66%] in the artery, 7/10 [70%] in the vein) and cTnT (2/10 [20%] in the vein) were increased. In fetuses with IUGR in the vein, NT-proBNP (10/41 [24%]) and cTnT (5/41 [12%]) were increased, whereas S100 (9/41 [21%]) was decreased. CONCLUSION: In a subset of neonates with cardiac defects or growth restriction, irrespective of the pH at birth, tissue-specific injury markers for the heart in umbilical cord blood are abnormal. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1401984
- author
- Kocylowski, Rafal D. ; Dubiel, Mariusz ; Gudmundsson, Saemundur LU ; Sieg, Ina ; Fritzer, Elfriede ; Alkasi, Oezkan ; Breborowicz, Gregory H. and von Kaisenberg, Constantin S.
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cardiac defects, intrauterine growth restriction, umbilical cord blood
- in
- American Journal of Obstetrics and Gynecology
- volume
- 200
- issue
- 3
- pages
- 1 - 273
- publisher
- Elsevier
- external identifiers
-
- wos:000264402700021
- scopus:60849121064
- pmid:19167692
- ISSN
- 1097-6868
- DOI
- 10.1016/j.ajog.2008.10.009
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 47b0d4ac-7884-4579-a67f-f83bf27e8156 (old id 1401984)
- date added to LUP
- 2016-04-01 12:01:30
- date last changed
- 2022-01-26 21:45:05
@article{47b0d4ac-7884-4579-a67f-f83bf27e8156,
abstract = {{OBJECTIVE: We sought to establish references ranges and to test the hypothesis that biochemical tissue-specific markers for the heart in umbilical cord blood of newborns with cardiac defects and intrauterine growth restriction (IUGR) are abnormal. STUDY DESIGN: A prospective study was conducted. Serum samples of the umbilical vein (n = 280) and artery (n = 156) from 599 healthy newborns at 37(+0)-42(+0) weeks of gestation were collected. Total creatine kinase (CK), CK-MB heart type (CK-MB), cardiac troponin T (cTnT), myoglobin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and S100 were measured. Reference ranges for each marker were constructed. Concentrations of tissue-specific markers from umbilical cord blood of neonates with cardiac defects (n = 10) and IUGR (n = 41) were plotted against the established reference ranges. RESULTS: Reference ranges for each studied marker were established for both umbilical artery and vein. In fetuses with cardiac defects, both NT-proBNP (4/6 [66%] in the artery, 7/10 [70%] in the vein) and cTnT (2/10 [20%] in the vein) were increased. In fetuses with IUGR in the vein, NT-proBNP (10/41 [24%]) and cTnT (5/41 [12%]) were increased, whereas S100 (9/41 [21%]) was decreased. CONCLUSION: In a subset of neonates with cardiac defects or growth restriction, irrespective of the pH at birth, tissue-specific injury markers for the heart in umbilical cord blood are abnormal.}},
author = {{Kocylowski, Rafal D. and Dubiel, Mariusz and Gudmundsson, Saemundur and Sieg, Ina and Fritzer, Elfriede and Alkasi, Oezkan and Breborowicz, Gregory H. and von Kaisenberg, Constantin S.}},
issn = {{1097-6868}},
keywords = {{cardiac defects; intrauterine growth restriction; umbilical cord blood}},
language = {{eng}},
number = {{3}},
pages = {{1--273}},
publisher = {{Elsevier}},
series = {{American Journal of Obstetrics and Gynecology}},
title = {{Biochemical tissue-specific injury markers of the heart and brain in postpartum cord blood}},
url = {{http://dx.doi.org/10.1016/j.ajog.2008.10.009}},
doi = {{10.1016/j.ajog.2008.10.009}},
volume = {{200}},
year = {{2009}},
}