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Biochemical tissue-specific injury markers of the heart and brain in postpartum cord blood

Kocylowski, Rafal D. ; Dubiel, Mariusz ; Gudmundsson, Saemundur LU ; Sieg, Ina ; Fritzer, Elfriede ; Alkasi, Oezkan ; Breborowicz, Gregory H. and von Kaisenberg, Constantin S. (2009) In American Journal of Obstetrics and Gynecology 200(3). p.1-273
Abstract
OBJECTIVE: We sought to establish references ranges and to test the hypothesis that biochemical tissue-specific markers for the heart in umbilical cord blood of newborns with cardiac defects and intrauterine growth restriction (IUGR) are abnormal. STUDY DESIGN: A prospective study was conducted. Serum samples of the umbilical vein (n = 280) and artery (n = 156) from 599 healthy newborns at 37(+0)-42(+0) weeks of gestation were collected. Total creatine kinase (CK), CK-MB heart type (CK-MB), cardiac troponin T (cTnT), myoglobin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and S100 were measured. Reference ranges for each marker were constructed. Concentrations of tissue-specific markers from umbilical cord blood of neonates with... (More)
OBJECTIVE: We sought to establish references ranges and to test the hypothesis that biochemical tissue-specific markers for the heart in umbilical cord blood of newborns with cardiac defects and intrauterine growth restriction (IUGR) are abnormal. STUDY DESIGN: A prospective study was conducted. Serum samples of the umbilical vein (n = 280) and artery (n = 156) from 599 healthy newborns at 37(+0)-42(+0) weeks of gestation were collected. Total creatine kinase (CK), CK-MB heart type (CK-MB), cardiac troponin T (cTnT), myoglobin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and S100 were measured. Reference ranges for each marker were constructed. Concentrations of tissue-specific markers from umbilical cord blood of neonates with cardiac defects (n = 10) and IUGR (n = 41) were plotted against the established reference ranges. RESULTS: Reference ranges for each studied marker were established for both umbilical artery and vein. In fetuses with cardiac defects, both NT-proBNP (4/6 [66%] in the artery, 7/10 [70%] in the vein) and cTnT (2/10 [20%] in the vein) were increased. In fetuses with IUGR in the vein, NT-proBNP (10/41 [24%]) and cTnT (5/41 [12%]) were increased, whereas S100 (9/41 [21%]) was decreased. CONCLUSION: In a subset of neonates with cardiac defects or growth restriction, irrespective of the pH at birth, tissue-specific injury markers for the heart in umbilical cord blood are abnormal. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
keywords
cardiac defects, intrauterine growth restriction, umbilical cord blood
in
American Journal of Obstetrics and Gynecology
volume
200
issue
3
pages
1 - 273
publisher
Elsevier
external identifiers
  • wos:000264402700021
  • scopus:60849121064
  • pmid:19167692
ISSN
1097-6868
DOI
10.1016/j.ajog.2008.10.009
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400)
id
47b0d4ac-7884-4579-a67f-f83bf27e8156 (old id 1401984)
date added to LUP
2016-04-01 12:01:30
date last changed
2025-04-03 18:28:52
@article{47b0d4ac-7884-4579-a67f-f83bf27e8156,
  abstract     = {{OBJECTIVE: We sought to establish references ranges and to test the hypothesis that biochemical tissue-specific markers for the heart in umbilical cord blood of newborns with cardiac defects and intrauterine growth restriction (IUGR) are abnormal. STUDY DESIGN: A prospective study was conducted. Serum samples of the umbilical vein (n = 280) and artery (n = 156) from 599 healthy newborns at 37(+0)-42(+0) weeks of gestation were collected. Total creatine kinase (CK), CK-MB heart type (CK-MB), cardiac troponin T (cTnT), myoglobin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and S100 were measured. Reference ranges for each marker were constructed. Concentrations of tissue-specific markers from umbilical cord blood of neonates with cardiac defects (n = 10) and IUGR (n = 41) were plotted against the established reference ranges. RESULTS: Reference ranges for each studied marker were established for both umbilical artery and vein. In fetuses with cardiac defects, both NT-proBNP (4/6 [66%] in the artery, 7/10 [70%] in the vein) and cTnT (2/10 [20%] in the vein) were increased. In fetuses with IUGR in the vein, NT-proBNP (10/41 [24%]) and cTnT (5/41 [12%]) were increased, whereas S100 (9/41 [21%]) was decreased. CONCLUSION: In a subset of neonates with cardiac defects or growth restriction, irrespective of the pH at birth, tissue-specific injury markers for the heart in umbilical cord blood are abnormal.}},
  author       = {{Kocylowski, Rafal D. and Dubiel, Mariusz and Gudmundsson, Saemundur and Sieg, Ina and Fritzer, Elfriede and Alkasi, Oezkan and Breborowicz, Gregory H. and von Kaisenberg, Constantin S.}},
  issn         = {{1097-6868}},
  keywords     = {{cardiac defects; intrauterine growth restriction; umbilical cord blood}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1--273}},
  publisher    = {{Elsevier}},
  series       = {{American Journal of Obstetrics and Gynecology}},
  title        = {{Biochemical tissue-specific injury markers of the heart and brain in postpartum cord blood}},
  url          = {{http://dx.doi.org/10.1016/j.ajog.2008.10.009}},
  doi          = {{10.1016/j.ajog.2008.10.009}},
  volume       = {{200}},
  year         = {{2009}},
}