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Substance P antagonist inhibits immediate and delayed type cutaneous hypersensitivity reactions.

Wallengren, Joanna LU orcid (1991) In British Journal of Dermatology 124(4). p.324-328
Abstract
The role of substance P (SP) in allergic reactions of the skin was investigated. Spantide, a competitive inhibitor of SP, was injected intracutaneously into the volar aspect of the forearm prior to the following challenges: benzalkonium chloride (irritant delayed reaction), tuberculin (immunological delayed reaction), UVB irradiation, benzoic acid (non-immunological contact urticaria), different food allergens and latex (in patients with immunological contact urticaria). Only the immunological reactions of contact urticaria and the reaction to tuberculin were suppressed by the SP antagonist, indicating that SP is involved in their pathogenesis.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Dermatology
volume
124
issue
4
pages
324 - 328
publisher
Wiley-Blackwell
external identifiers
  • scopus:0025825112
ISSN
1365-2133
DOI
10.1111/j.1365-2133.1991.tb00591.x
language
English
LU publication?
yes
id
47e90b85-4c47-4ba2-b6f0-b789c8a0480b
date added to LUP
2019-07-17 16:18:15
date last changed
2021-01-03 11:05:06
@article{47e90b85-4c47-4ba2-b6f0-b789c8a0480b,
  abstract     = {{The role of substance P (SP) in allergic reactions of the skin was investigated. Spantide, a competitive inhibitor of SP, was injected intracutaneously into the volar aspect of the forearm prior to the following challenges: benzalkonium chloride (irritant delayed reaction), tuberculin (immunological delayed reaction), UVB irradiation, benzoic acid (non-immunological contact urticaria), different food allergens and latex (in patients with immunological contact urticaria). Only the immunological reactions of contact urticaria and the reaction to tuberculin were suppressed by the SP antagonist, indicating that SP is involved in their pathogenesis.}},
  author       = {{Wallengren, Joanna}},
  issn         = {{1365-2133}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{324--328}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{British Journal of Dermatology}},
  title        = {{Substance P antagonist inhibits immediate and delayed type cutaneous hypersensitivity reactions.}},
  url          = {{http://dx.doi.org/10.1111/j.1365-2133.1991.tb00591.x}},
  doi          = {{10.1111/j.1365-2133.1991.tb00591.x}},
  volume       = {{124}},
  year         = {{1991}},
}