Treatment effects of two pharmaceutical skin care creams for xerotic feet among persons with diabetes : Rationale and design of a two-armed double blind randomized controlled trial
(2024) In Contemporary Clinical Trials Communications 42.- Abstract
Introduction: To minimize the risk of developing foot-ulcers, persons with diabetes are given the advice to daily inspect their feet and to apply skincare formulations. However, commercially available skincare products have rarely been developed and evaluated for diabetes foot care specifically. The primary aim of this randomized controlled trial (RCT) is to evaluate the effects in reducing foot xerosis in persons with diabetes without foot-ulcers using two skincare creams containing different humectants (interventions) against a cream base non-humectant (comparator). Secondary outcomes are to evaluate differences on skin barrier integrity, low-molecular weight biomarkers and skin microbiota, microcirculation including transcutaneous... (More)
Introduction: To minimize the risk of developing foot-ulcers, persons with diabetes are given the advice to daily inspect their feet and to apply skincare formulations. However, commercially available skincare products have rarely been developed and evaluated for diabetes foot care specifically. The primary aim of this randomized controlled trial (RCT) is to evaluate the effects in reducing foot xerosis in persons with diabetes without foot-ulcers using two skincare creams containing different humectants (interventions) against a cream base non-humectant (comparator). Secondary outcomes are to evaluate differences on skin barrier integrity, low-molecular weight biomarkers and skin microbiota, microcirculation including transcutaneous oxygen pressure, degree of neuropathy, and HbA1c between intervention-comparator creams. Methods: Two-armed double-blind RCT, registered in ClinicalTrials.gov Identifier: NCT06427889. With 80 % power, two-tailed significance of 2.5 % in each arm, 39 study persons is needed in each arm, total 78 persons, 98 including dropouts, to be able to prove a reduction of at least one category in the Xerosis Severity Scale with the intervention creams compared to the comparator. In one arm, each participant will treat one foot with one of the intervention creams (Oviderm® or Canoderm®), while the opposite foot will be treated with the comparator cream (Decubal®lipid cream), twice a day. If needed, participants are enrolled after a wash-out period of two weeks. The participants will undergo examinations at baseline, day 14 and day 28. Discussion: This RCT evaluate the potential effects of humectants in skin creams against foot xerosis in persons with diabetes.
(Less)
- author
- Ericsson, Anna
; Borgström, Karin
; Kumlien, Christine
LU
; Gershater Annersten, Magdalena
; Ruzgas, Tautgirdas
LU
; Engblom, Johan
; Gudmundsson, Petri
LU
; Lazer, Victoria
; Jankovskaja, Skaidre
; Lavant, Eva
; Ågren-Witteschus, Sophia
LU
; Björklund, Sebastian
; Salim, Saman
LU
; Åström, Mikael
and Acosta, Stefan
LU
(Less) - organization
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diabetes mellitus, Dry feet, Foot-xerosis, Prevention, Self-care
- in
- Contemporary Clinical Trials Communications
- volume
- 42
- article number
- 101372
- publisher
- Elsevier
- external identifiers
-
- scopus:85204406634
- pmid:39345688
- ISSN
- 2451-8654
- DOI
- 10.1016/j.conctc.2024.101372
- language
- English
- LU publication?
- yes
- id
- 4802e22c-c0ab-4867-9c41-0f9c75da9364
- date added to LUP
- 2024-11-12 16:16:08
- date last changed
- 2025-06-11 09:21:09
@article{4802e22c-c0ab-4867-9c41-0f9c75da9364,
abstract = {{<p>Introduction: To minimize the risk of developing foot-ulcers, persons with diabetes are given the advice to daily inspect their feet and to apply skincare formulations. However, commercially available skincare products have rarely been developed and evaluated for diabetes foot care specifically. The primary aim of this randomized controlled trial (RCT) is to evaluate the effects in reducing foot xerosis in persons with diabetes without foot-ulcers using two skincare creams containing different humectants (interventions) against a cream base non-humectant (comparator). Secondary outcomes are to evaluate differences on skin barrier integrity, low-molecular weight biomarkers and skin microbiota, microcirculation including transcutaneous oxygen pressure, degree of neuropathy, and HbA1c between intervention-comparator creams. Methods: Two-armed double-blind RCT, registered in ClinicalTrials.gov Identifier: NCT06427889. With 80 % power, two-tailed significance of 2.5 % in each arm, 39 study persons is needed in each arm, total 78 persons, 98 including dropouts, to be able to prove a reduction of at least one category in the Xerosis Severity Scale with the intervention creams compared to the comparator. In one arm, each participant will treat one foot with one of the intervention creams (Oviderm® or Canoderm®), while the opposite foot will be treated with the comparator cream (Decubal®lipid cream), twice a day. If needed, participants are enrolled after a wash-out period of two weeks. The participants will undergo examinations at baseline, day 14 and day 28. Discussion: This RCT evaluate the potential effects of humectants in skin creams against foot xerosis in persons with diabetes.</p>}},
author = {{Ericsson, Anna and Borgström, Karin and Kumlien, Christine and Gershater Annersten, Magdalena and Ruzgas, Tautgirdas and Engblom, Johan and Gudmundsson, Petri and Lazer, Victoria and Jankovskaja, Skaidre and Lavant, Eva and Ågren-Witteschus, Sophia and Björklund, Sebastian and Salim, Saman and Åström, Mikael and Acosta, Stefan}},
issn = {{2451-8654}},
keywords = {{Diabetes mellitus; Dry feet; Foot-xerosis; Prevention; Self-care}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Contemporary Clinical Trials Communications}},
title = {{Treatment effects of two pharmaceutical skin care creams for xerotic feet among persons with diabetes : Rationale and design of a two-armed double blind randomized controlled trial}},
url = {{http://dx.doi.org/10.1016/j.conctc.2024.101372}},
doi = {{10.1016/j.conctc.2024.101372}},
volume = {{42}},
year = {{2024}},
}