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Testis dosimetry in individual patients by combining a small-scale dosimetry model and pharmacokinetic modeling-application of (111)In-Ibritumomab Tiuxetan (Zevalin(®)).

Meerkhan, Suaad LU ; Sjögreen Gleisner, Katarina LU ; Larsson, Erik LU ; Strand, Sven-Erik LU and Jönsson, Bo-Anders LU (2014) In Physics in Medicine and Biology 59(24). p.7889-7904
Abstract
A heterogeneous distribution of radionuclides emitting low-energy electrons in the testicles may result in a significant difference between an absorbed dose to the radiosensitive spermatogonia and the mean absorbed dose to the whole testis. This study focused on absorbed dose distribution in patients at a finer scale than normally available in clinical dosimetry, which was accomplished by combining a small-scale dosimetry model with patient pharmacokinetic data. The activity in the testes was measured and blood sampling was performed for patients that underwent pre-therapy imaging with (111)In-Zevalin(®). Using compartment modeling, testicular activity was separated into two components: vascular and extravascular. The uncertainty of... (More)
A heterogeneous distribution of radionuclides emitting low-energy electrons in the testicles may result in a significant difference between an absorbed dose to the radiosensitive spermatogonia and the mean absorbed dose to the whole testis. This study focused on absorbed dose distribution in patients at a finer scale than normally available in clinical dosimetry, which was accomplished by combining a small-scale dosimetry model with patient pharmacokinetic data. The activity in the testes was measured and blood sampling was performed for patients that underwent pre-therapy imaging with (111)In-Zevalin(®). Using compartment modeling, testicular activity was separated into two components: vascular and extravascular. The uncertainty of absorbed dose due to geometry variations between testicles was explored by an assumed activity micro-distribution and by varying the radius of the interstitial tubule. Results showed that the absorbed dose to germ cells might be strongly dependent on the location of the radioactive source, and may exceed the absorbed dose to the whole testis by as much as a factor of two. Small-scale dosimetry combined with compartmental analysis of clinical data proved useful for gauging tissue dosimetry and interpreting how intrinsic geometric variation influences the absorbed dose. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
59
issue
24
pages
7889 - 7904
publisher
IOP Publishing
external identifiers
  • pmid:25426744
  • scopus:84924386138
ISSN
1361-6560
DOI
10.1088/0031-9155/59/24/7889
language
English
LU publication?
yes
id
642e46de-c72b-4b4e-95c7-3536b54785e6 (old id 4815941)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25426744?dopt=Abstract
date added to LUP
2014-12-06 18:55:47
date last changed
2017-01-01 03:26:35
@article{642e46de-c72b-4b4e-95c7-3536b54785e6,
  abstract     = {A heterogeneous distribution of radionuclides emitting low-energy electrons in the testicles may result in a significant difference between an absorbed dose to the radiosensitive spermatogonia and the mean absorbed dose to the whole testis. This study focused on absorbed dose distribution in patients at a finer scale than normally available in clinical dosimetry, which was accomplished by combining a small-scale dosimetry model with patient pharmacokinetic data. The activity in the testes was measured and blood sampling was performed for patients that underwent pre-therapy imaging with (111)In-Zevalin(®). Using compartment modeling, testicular activity was separated into two components: vascular and extravascular. The uncertainty of absorbed dose due to geometry variations between testicles was explored by an assumed activity micro-distribution and by varying the radius of the interstitial tubule. Results showed that the absorbed dose to germ cells might be strongly dependent on the location of the radioactive source, and may exceed the absorbed dose to the whole testis by as much as a factor of two. Small-scale dosimetry combined with compartmental analysis of clinical data proved useful for gauging tissue dosimetry and interpreting how intrinsic geometric variation influences the absorbed dose.},
  author       = {Meerkhan, Suaad and Sjögreen Gleisner, Katarina and Larsson, Erik and Strand, Sven-Erik and Jönsson, Bo-Anders},
  issn         = {1361-6560},
  language     = {eng},
  number       = {24},
  pages        = {7889--7904},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {Testis dosimetry in individual patients by combining a small-scale dosimetry model and pharmacokinetic modeling-application of (111)In-Ibritumomab Tiuxetan (Zevalin(®)).},
  url          = {http://dx.doi.org/10.1088/0031-9155/59/24/7889},
  volume       = {59},
  year         = {2014},
}