Four Areas of Engagement Requiring Strengthening in Modern Proteomics Today.
(2014) In Journal of Proteome Research 13(12). p.5310-5318- Abstract
- The global human proteomics community in 2014 is fully engaged in projects that aim to create a better understanding of human biology and its complexities and to provide products from this new knowledge that will in some way benefit humanity. Human proteomics, like any other scientific enterprise, needs to identify areas of direction and development, both for the near future in completing current research projects and into the long-term for the engagement with even more complex challenges. In this Editorial we highlight and discuss four important areas that we collectively believe require attention and demand a collective response going forward. These four areas are: (1) Provide high-quality standardized, sensitive, specific, quantitative,... (More)
- The global human proteomics community in 2014 is fully engaged in projects that aim to create a better understanding of human biology and its complexities and to provide products from this new knowledge that will in some way benefit humanity. Human proteomics, like any other scientific enterprise, needs to identify areas of direction and development, both for the near future in completing current research projects and into the long-term for the engagement with even more complex challenges. In this Editorial we highlight and discuss four important areas that we collectively believe require attention and demand a collective response going forward. These four areas are: (1) Provide high-quality standardized, sensitive, specific, quantitative, and readily accessible protein, peptide, or other biomarkers of health, disease, response to therapy into the approval processes of regulatory agencies (e.g., U.S. Food and Drug Administration; FDA), and obtaining approval from the relevant agencies for their use in a clinical or other testing settings. (2) Implement standard processes for collecting, processing, and storing human clinical samples in biorepositories and enforcement of measures to ensure subject integrity including informed consent for the downstream use of samples and in registrations of subject identities within study databases. (3) Test and validate mass spectrometry technology platforms that hold much promise for creating opportunities for obtaining new important knowledge at levels of detection previously not achievable. (4) Organize clinical discovery operations and activities in an intuitive manner to meet the challenges of increased interests in the science we provide and diminishing levels of centrally financed resource and infrastructure support. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4816446
- author
- Fehniger, Thomas LU ; Boja, Emily S ; Rodriguez, Henry ; Baker, Mark S and Marko-Varga, György LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Proteome Research
- volume
- 13
- issue
- 12
- pages
- 5310 - 5318
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:25405748
- wos:000346039400003
- scopus:84915822559
- pmid:25405748
- ISSN
- 1535-3893
- DOI
- 10.1021/pr500472d
- language
- English
- LU publication?
- yes
- id
- ac00f65f-4bc6-4afa-bc0d-0afb395df0b2 (old id 4816446)
- date added to LUP
- 2016-04-01 10:49:13
- date last changed
- 2022-01-26 02:49:37
@misc{ac00f65f-4bc6-4afa-bc0d-0afb395df0b2,
abstract = {{The global human proteomics community in 2014 is fully engaged in projects that aim to create a better understanding of human biology and its complexities and to provide products from this new knowledge that will in some way benefit humanity. Human proteomics, like any other scientific enterprise, needs to identify areas of direction and development, both for the near future in completing current research projects and into the long-term for the engagement with even more complex challenges. In this Editorial we highlight and discuss four important areas that we collectively believe require attention and demand a collective response going forward. These four areas are: (1) Provide high-quality standardized, sensitive, specific, quantitative, and readily accessible protein, peptide, or other biomarkers of health, disease, response to therapy into the approval processes of regulatory agencies (e.g., U.S. Food and Drug Administration; FDA), and obtaining approval from the relevant agencies for their use in a clinical or other testing settings. (2) Implement standard processes for collecting, processing, and storing human clinical samples in biorepositories and enforcement of measures to ensure subject integrity including informed consent for the downstream use of samples and in registrations of subject identities within study databases. (3) Test and validate mass spectrometry technology platforms that hold much promise for creating opportunities for obtaining new important knowledge at levels of detection previously not achievable. (4) Organize clinical discovery operations and activities in an intuitive manner to meet the challenges of increased interests in the science we provide and diminishing levels of centrally financed resource and infrastructure support.}},
author = {{Fehniger, Thomas and Boja, Emily S and Rodriguez, Henry and Baker, Mark S and Marko-Varga, György}},
issn = {{1535-3893}},
language = {{eng}},
number = {{12}},
pages = {{5310--5318}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Journal of Proteome Research}},
title = {{Four Areas of Engagement Requiring Strengthening in Modern Proteomics Today.}},
url = {{http://dx.doi.org/10.1021/pr500472d}},
doi = {{10.1021/pr500472d}},
volume = {{13}},
year = {{2014}},
}