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The growth hormone receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population.

Glad, Camilla A M; Carlsson, Lena M S; Melander, Olle LU ; Almgren, Peter LU ; Sjöström, Lars; Nilsson, Staffan; Larsson, Ingrid; Svensson, Per-Arne and Johannsson, Gudmundur (2015) In European Journal of Endocrinology 172(2).
Abstract
Objective: To test the hypothesis that the growth hormone (GH) receptor (GHR) d3/fl polymorphism influences anthropometry and body composition in the general population. Design and Setting: The Swedish Obese Subjects (SOS) reference study is a cross-sectional population-based study, randomly selected from a population registry. A sub-group of the population-based Malmö Diet and Cancer Study (MDC-CC) was used as a replication cohort. Methods: The SOS reference study comprises 1135 subjects (46.2% men), with an average age of 49.5 yrs. The MDC-CC includes 5451 successfully genotyped subjects (41.5% men), with an average age of 57.5 yrs. GHR d3/fl genotypes were determined using tagSNP rs6873545. Linear regression analyses were used to test... (More)
Objective: To test the hypothesis that the growth hormone (GH) receptor (GHR) d3/fl polymorphism influences anthropometry and body composition in the general population. Design and Setting: The Swedish Obese Subjects (SOS) reference study is a cross-sectional population-based study, randomly selected from a population registry. A sub-group of the population-based Malmö Diet and Cancer Study (MDC-CC) was used as a replication cohort. Methods: The SOS reference study comprises 1135 subjects (46.2% men), with an average age of 49.5 yrs. The MDC-CC includes 5451 successfully genotyped subjects (41.5% men), with an average age of 57.5 yrs. GHR d3/fl genotypes were determined using tagSNP rs6873545. Linear regression analyses were used to test for genotype - phenotype associations. Results: In the SOS reference study, subjects homozygous for the d3-GHR weighed approximately four kilos more (p=0.011), had larger waist-to-hip ratio (WHR, p=0.036), waist circumference (p=0.016) and more fat free mass estimated from total body potassium (TBK, p=0.026) than grouped fl/d3 and fl/fl subjects (d3-recessive genetic model). The association with WHR was replicated in the MDC-CC (p=0.002), but not those with other anthropometric traits. Conclusions: In this population-based study the GHR d3/fl polymorphism was found to be of functional relevance and associated with central adiposity, such that subjects homozygous for the d3-GHR showed an increased abdominal obesity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Endocrinology
volume
172
issue
2
publisher
Society of the European Journal of Endocrinology
external identifiers
  • pmid:25391539
  • wos:000349458000009
  • scopus:84922513349
ISSN
1479-683X
DOI
10.1530/EJE-14-0723
language
English
LU publication?
yes
id
48b1e4f1-33fe-4aca-ac22-44c8ca6ea610 (old id 4816827)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25391539?dopt=Abstract
date added to LUP
2014-12-02 16:24:52
date last changed
2017-11-05 03:07:14
@article{48b1e4f1-33fe-4aca-ac22-44c8ca6ea610,
  abstract     = {Objective: To test the hypothesis that the growth hormone (GH) receptor (GHR) d3/fl polymorphism influences anthropometry and body composition in the general population. Design and Setting: The Swedish Obese Subjects (SOS) reference study is a cross-sectional population-based study, randomly selected from a population registry. A sub-group of the population-based Malmö Diet and Cancer Study (MDC-CC) was used as a replication cohort. Methods: The SOS reference study comprises 1135 subjects (46.2% men), with an average age of 49.5 yrs. The MDC-CC includes 5451 successfully genotyped subjects (41.5% men), with an average age of 57.5 yrs. GHR d3/fl genotypes were determined using tagSNP rs6873545. Linear regression analyses were used to test for genotype - phenotype associations. Results: In the SOS reference study, subjects homozygous for the d3-GHR weighed approximately four kilos more (p=0.011), had larger waist-to-hip ratio (WHR, p=0.036), waist circumference (p=0.016) and more fat free mass estimated from total body potassium (TBK, p=0.026) than grouped fl/d3 and fl/fl subjects (d3-recessive genetic model). The association with WHR was replicated in the MDC-CC (p=0.002), but not those with other anthropometric traits. Conclusions: In this population-based study the GHR d3/fl polymorphism was found to be of functional relevance and associated with central adiposity, such that subjects homozygous for the d3-GHR showed an increased abdominal obesity.},
  author       = {Glad, Camilla A M and Carlsson, Lena M S and Melander, Olle and Almgren, Peter and Sjöström, Lars and Nilsson, Staffan and Larsson, Ingrid and Svensson, Per-Arne and Johannsson, Gudmundur},
  issn         = {1479-683X},
  language     = {eng},
  number       = {2},
  publisher    = {Society of the European Journal of Endocrinology},
  series       = {European Journal of Endocrinology},
  title        = {The growth hormone receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population.},
  url          = {http://dx.doi.org/10.1530/EJE-14-0723},
  volume       = {172},
  year         = {2015},
}