The growth hormone receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population.
Glad, Camilla A M ; Carlsson, Lena M S ; Melander, Olle LU
; Almgren, Peter
LU
; Sjöström, Lars
; Nilsson, Staffan
; Larsson, Ingrid
; Svensson, Per-Arne
and Johannsson, Gudmundur
(2015)
In European Journal of Endocrinology
172(2).
- Abstract
- Objective: To test the hypothesis that the growth hormone (GH) receptor (GHR) d3/fl polymorphism influences anthropometry and body composition in the general population. Design and Setting: The Swedish Obese Subjects (SOS) reference study is a cross-sectional population-based study, randomly selected from a population registry. A sub-group of the population-based Malmö Diet and Cancer Study (MDC-CC) was used as a replication cohort. Methods: The SOS reference study comprises 1135 subjects (46.2% men), with an average age of 49.5 yrs. The MDC-CC includes 5451 successfully genotyped subjects (41.5% men), with an average age of 57.5 yrs. GHR d3/fl genotypes were determined using tagSNP rs6873545. Linear regression analyses were used to test... (More)
- Objective: To test the hypothesis that the growth hormone (GH) receptor (GHR) d3/fl polymorphism influences anthropometry and body composition in the general population. Design and Setting: The Swedish Obese Subjects (SOS) reference study is a cross-sectional population-based study, randomly selected from a population registry. A sub-group of the population-based Malmö Diet and Cancer Study (MDC-CC) was used as a replication cohort. Methods: The SOS reference study comprises 1135 subjects (46.2% men), with an average age of 49.5 yrs. The MDC-CC includes 5451 successfully genotyped subjects (41.5% men), with an average age of 57.5 yrs. GHR d3/fl genotypes were determined using tagSNP rs6873545. Linear regression analyses were used to test for genotype - phenotype associations. Results: In the SOS reference study, subjects homozygous for the d3-GHR weighed approximately four kilos more (p=0.011), had larger waist-to-hip ratio (WHR, p=0.036), waist circumference (p=0.016) and more fat free mass estimated from total body potassium (TBK, p=0.026) than grouped fl/d3 and fl/fl subjects (d3-recessive genetic model). The association with WHR was replicated in the MDC-CC (p=0.002), but not those with other anthropometric traits. Conclusions: In this population-based study the GHR d3/fl polymorphism was found to be of functional relevance and associated with central adiposity, such that subjects homozygous for the d3-GHR showed an increased abdominal obesity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4816827
- author
- Glad, Camilla A M
; Carlsson, Lena M S
; Melander, Olle
LU
; Almgren, Peter
LU
; Sjöström, Lars
; Nilsson, Staffan
; Larsson, Ingrid
; Svensson, Per-Arne
and Johannsson, Gudmundur
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Endocrinology
- volume
- 172
- issue
- 2
- publisher
- Society of the European Journal of Endocrinology
- external identifiers
-
- pmid:25391539
- wos:000349458000009
- scopus:84922513349
- pmid:25391539
- ISSN
- 1479-683X
- DOI
- 10.1530/EJE-14-0723
- language
- English
- LU publication?
- yes
- id
- 48b1e4f1-33fe-4aca-ac22-44c8ca6ea610 (old id 4816827)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25391539?dopt=Abstract
- date added to LUP
- 2016-04-01 10:10:11
- date last changed
- 2024-04-07 02:55:39
@article{48b1e4f1-33fe-4aca-ac22-44c8ca6ea610,
abstract = {{Objective: To test the hypothesis that the growth hormone (GH) receptor (GHR) d3/fl polymorphism influences anthropometry and body composition in the general population. Design and Setting: The Swedish Obese Subjects (SOS) reference study is a cross-sectional population-based study, randomly selected from a population registry. A sub-group of the population-based Malmö Diet and Cancer Study (MDC-CC) was used as a replication cohort. Methods: The SOS reference study comprises 1135 subjects (46.2% men), with an average age of 49.5 yrs. The MDC-CC includes 5451 successfully genotyped subjects (41.5% men), with an average age of 57.5 yrs. GHR d3/fl genotypes were determined using tagSNP rs6873545. Linear regression analyses were used to test for genotype - phenotype associations. Results: In the SOS reference study, subjects homozygous for the d3-GHR weighed approximately four kilos more (p=0.011), had larger waist-to-hip ratio (WHR, p=0.036), waist circumference (p=0.016) and more fat free mass estimated from total body potassium (TBK, p=0.026) than grouped fl/d3 and fl/fl subjects (d3-recessive genetic model). The association with WHR was replicated in the MDC-CC (p=0.002), but not those with other anthropometric traits. Conclusions: In this population-based study the GHR d3/fl polymorphism was found to be of functional relevance and associated with central adiposity, such that subjects homozygous for the d3-GHR showed an increased abdominal obesity.}},
author = {{Glad, Camilla A M and Carlsson, Lena M S and Melander, Olle and Almgren, Peter and Sjöström, Lars and Nilsson, Staffan and Larsson, Ingrid and Svensson, Per-Arne and Johannsson, Gudmundur}},
issn = {{1479-683X}},
language = {{eng}},
number = {{2}},
publisher = {{Society of the European Journal of Endocrinology}},
series = {{European Journal of Endocrinology}},
title = {{The growth hormone receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population.}},
url = {{http://dx.doi.org/10.1530/EJE-14-0723}},
doi = {{10.1530/EJE-14-0723}},
volume = {{172}},
year = {{2015}},
}