An update on the GLOB blood group system and collection.
Hellberg, Åsa LU ; Westman, Julia LU and Olsson, Martin L LU
(2013)
In Immunohematology
29(1).
p.19-24
- Abstract
- The P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside, on the red blood cells (RBCs) of almost all individuals worldwide. The P antigen is intimately related to the Pk and NOR antigens discussed in the review about the P1PK blood group system. Naturally occurring anti-P is present in the serum of individuals with the rare globoside-deficient phenotypes p, P1k, and P2k and has been implicated in hemolytic transfusion reactions as well as unfavorable outcomes of pregnancy. The molecular genetic basis of globoside deficiency is absence of functional P synthase as a result of mutations at the B3GALNT1 locus. Other related glycolipid structures, the LKE and PX2 antigens, remain in the GLOB blood group... (More)
- The P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside, on the red blood cells (RBCs) of almost all individuals worldwide. The P antigen is intimately related to the Pk and NOR antigens discussed in the review about the P1PK blood group system. Naturally occurring anti-P is present in the serum of individuals with the rare globoside-deficient phenotypes p, P1k, and P2k and has been implicated in hemolytic transfusion reactions as well as unfavorable outcomes of pregnancy. The molecular genetic basis of globoside deficiency is absence of functional P synthase as a result of mutations at the B3GALNT1 locus. Other related glycolipid structures, the LKE and PX2 antigens, remain in the GLOB blood group collection pending further evidence about the genes and gene products responsible for their synthesis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4065684
- author
- Hellberg, Åsa
LU
; Westman, Julia
LU
and Olsson, Martin L
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunohematology
- volume
- 29
- issue
- 1
- pages
- 19 - 24
- publisher
- American Red Cross
- external identifiers
-
- pmid:24046919
- scopus:84885832053
- ISSN
- 0894-203X
- language
- English
- LU publication?
- yes
- id
- 481b10f3-5db9-45d1-bdf1-bf957536a5d4 (old id 4065684)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24046919?dopt=Abstract
- date added to LUP
- 2016-04-01 13:14:54
- date last changed
- 2022-01-27 18:07:42
@article{481b10f3-5db9-45d1-bdf1-bf957536a5d4,
abstract = {{The P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside, on the red blood cells (RBCs) of almost all individuals worldwide. The P antigen is intimately related to the Pk and NOR antigens discussed in the review about the P1PK blood group system. Naturally occurring anti-P is present in the serum of individuals with the rare globoside-deficient phenotypes p, P1k, and P2k and has been implicated in hemolytic transfusion reactions as well as unfavorable outcomes of pregnancy. The molecular genetic basis of globoside deficiency is absence of functional P synthase as a result of mutations at the B3GALNT1 locus. Other related glycolipid structures, the LKE and PX2 antigens, remain in the GLOB blood group collection pending further evidence about the genes and gene products responsible for their synthesis.}},
author = {{Hellberg, Åsa and Westman, Julia and Olsson, Martin L}},
issn = {{0894-203X}},
language = {{eng}},
number = {{1}},
pages = {{19--24}},
publisher = {{American Red Cross}},
series = {{Immunohematology}},
title = {{An update on the GLOB blood group system and collection.}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/24046919?dopt=Abstract}},
volume = {{29}},
year = {{2013}},
}