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The intracellular distribution of Cobalt in exposed and unexposed rat myocardium

Clyne, N. LU ; Persson, B.; Havu, N.; Hultman, E.; Lins, L. E.; Pehrsson, S. K.; Rydstrom, J. and Wibom, R. (1990) In Scandinavian Journal of Clinical & Laboratory Investigation 50(6). p.605-609
Abstract

The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS04-7 H20/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had... (More)

The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS04-7 H20/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had the highest levels of cobalt. This could affect calcium flux in myocardial cells and, secondarily, tension development in cardiac muscle.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Cobalt, Rat myocardium, Subcellular fractions
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
50
issue
6
pages
5 pages
publisher
Informa Healthcare
external identifiers
  • scopus:0025061243
ISSN
0036-5513
DOI
10.3109/00365519009089177
language
English
LU publication?
no
id
485e399e-f314-45a0-a860-1fb8f29ab764
date added to LUP
2016-08-30 22:07:17
date last changed
2018-01-07 11:24:56
@article{485e399e-f314-45a0-a860-1fb8f29ab764,
  abstract     = {<p>The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS0<sub>4</sub>-7 H<sub>2</sub>0/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had the highest levels of cobalt. This could affect calcium flux in myocardial cells and, secondarily, tension development in cardiac muscle.</p>},
  author       = {Clyne, N. and Persson, B. and Havu, N. and Hultman, E. and Lins, L. E. and Pehrsson, S. K. and Rydstrom, J. and Wibom, R.},
  issn         = {0036-5513},
  keyword      = {Cobalt,Rat myocardium,Subcellular fractions},
  language     = {eng},
  number       = {6},
  pages        = {605--609},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {The intracellular distribution of Cobalt in exposed and unexposed rat myocardium},
  url          = {http://dx.doi.org/10.3109/00365519009089177},
  volume       = {50},
  year         = {1990},
}