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The intracellular distribution of Cobalt in exposed and unexposed rat myocardium

Clyne, N. LU orcid ; Persson, B. ; Havu, N. ; Hultman, E. ; Lins, L. E. ; Pehrsson, S. K. ; Rydstrom, J. and Wibom, R. (1990) In Scandinavian Journal of Clinical & Laboratory Investigation 50(6). p.605-609
Abstract

The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS04-7 H20/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had... (More)

The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS04-7 H20/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had the highest levels of cobalt. This could affect calcium flux in myocardial cells and, secondarily, tension development in cardiac muscle.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Cobalt, Rat myocardium, Subcellular fractions
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
50
issue
6
pages
5 pages
publisher
Informa Healthcare
external identifiers
  • scopus:0025061243
  • pmid:2247766
ISSN
0036-5513
DOI
10.3109/00365519009089177
language
English
LU publication?
no
id
485e399e-f314-45a0-a860-1fb8f29ab764
date added to LUP
2016-08-30 22:07:17
date last changed
2025-10-14 11:54:45
@article{485e399e-f314-45a0-a860-1fb8f29ab764,
  abstract     = {{<p>The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS0<sub>4</sub>-7 H<sub>2</sub>0/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had the highest levels of cobalt. This could affect calcium flux in myocardial cells and, secondarily, tension development in cardiac muscle.</p>}},
  author       = {{Clyne, N. and Persson, B. and Havu, N. and Hultman, E. and Lins, L. E. and Pehrsson, S. K. and Rydstrom, J. and Wibom, R.}},
  issn         = {{0036-5513}},
  keywords     = {{Cobalt; Rat myocardium; Subcellular fractions}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{605--609}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
  title        = {{The intracellular distribution of Cobalt in exposed and unexposed rat myocardium}},
  url          = {{http://dx.doi.org/10.3109/00365519009089177}},
  doi          = {{10.3109/00365519009089177}},
  volume       = {{50}},
  year         = {{1990}},
}