Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Rat alpha 1-microglobulin : co-expression in liver with the light chain of inter-alpha-trypsin inhibitor

Lindqvist, A LU ; Bratt, T ; Altieri, M ; Kastern, W and Akerström, B LU (1992) In Biochimica et Biophysica Acta 1130(1). p.7-63
Abstract

A 1162 bp rat liver cDNA clone encoding the immunoregulatory plasma protein alpha 1-microglobulin was isolated and sequenced. The open reading frame encoded a 349 amino acid polyprotein, including alpha 1-microglobulin, 182 amino acids, and bikunin, the light chain of the plasma protein inter-alpha-trypsin inhibitor, 145 amino acids. The alpha 1-microglobulin/bikunin mRNA was found only in the liver when different tissues were examined. Free alpha 1-microglobulin and a polyprotein, containing both alpha 1-microglobulin and inter-alpha-trypsin inhibitor epitopes, were found in the microsomal fraction from rat liver homogenates.

Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alpha-Globulins/chemistry, Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Glycoproteins/chemistry, Liver/metabolism, Membrane Glycoproteins, Molecular Sequence Data, Protein Precursors/chemistry, RNA, Messenger/genetics, Rats, Rats, Inbred Strains, Trypsin Inhibitor, Kunitz Soybean
in
Biochimica et Biophysica Acta
volume
1130
issue
1
pages
7 - 63
publisher
Elsevier
external identifiers
  • pmid:1371936
  • scopus:0026543131
ISSN
0006-3002
DOI
10.1016/0167-4781(92)90462-9
language
English
LU publication?
yes
id
48606fca-ffe1-45c8-befc-4e170afa0215
date added to LUP
2019-05-22 10:24:49
date last changed
2025-10-14 13:22:24
@article{48606fca-ffe1-45c8-befc-4e170afa0215,
  abstract     = {{<p>A 1162 bp rat liver cDNA clone encoding the immunoregulatory plasma protein alpha 1-microglobulin was isolated and sequenced. The open reading frame encoded a 349 amino acid polyprotein, including alpha 1-microglobulin, 182 amino acids, and bikunin, the light chain of the plasma protein inter-alpha-trypsin inhibitor, 145 amino acids. The alpha 1-microglobulin/bikunin mRNA was found only in the liver when different tissues were examined. Free alpha 1-microglobulin and a polyprotein, containing both alpha 1-microglobulin and inter-alpha-trypsin inhibitor epitopes, were found in the microsomal fraction from rat liver homogenates.</p>}},
  author       = {{Lindqvist, A and Bratt, T and Altieri, M and Kastern, W and Akerström, B}},
  issn         = {{0006-3002}},
  keywords     = {{Alpha-Globulins/chemistry; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Glycoproteins/chemistry; Liver/metabolism; Membrane Glycoproteins; Molecular Sequence Data; Protein Precursors/chemistry; RNA, Messenger/genetics; Rats; Rats, Inbred Strains; Trypsin Inhibitor, Kunitz Soybean}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{1}},
  pages        = {{7--63}},
  publisher    = {{Elsevier}},
  series       = {{Biochimica et Biophysica Acta}},
  title        = {{Rat alpha 1-microglobulin : co-expression in liver with the light chain of inter-alpha-trypsin inhibitor}},
  url          = {{http://dx.doi.org/10.1016/0167-4781(92)90462-9}},
  doi          = {{10.1016/0167-4781(92)90462-9}},
  volume       = {{1130}},
  year         = {{1992}},
}